Abstract: The invention disclosed herein relates generally to immunotherapy and, more specifically, to therapeutic methods for treating tumors and cancerous tissues by first inducing necrosis or apoptosis (e.g., cryotherapy, chemotherapy, radiation therapy, ultrasound therapy, or a combination thereof applied against at least a portion of the tumor or cancerous tissue), and then delivering one or more se doses of antigen presenting cells (e.g., autologous dendritic cells) intratumorally or proximate to the tumor or cancerous tissue, but only after a selected period of time sufficient for the bioavailability of liberated cancer-specific antigens (monitored over the selected period of time) resulting from the necrosis or apoptosis to be at or near a maximum value. The present invention provides an alternative strategy to the ex vivo loading of target antigen to antigen presenting cells such as, for example, enriched autologous dendritic cells for purposes of enhancing an immune response.

Abstract: This invention relates to apparatus for coordinating the indexing movement of a conveyor with pivotal movement of a kickout arm for removing workpieces from its delivery end. A double acting fluid powered cylinder alternately indexes the loop and pivots the kickout upon reciprocating movement of first and second piston rods thereof. Preferably, a rack is provided extending axially from the first of the rods. A pinion engages the rack and is operatively connected and disconnected from the loop by a clutch upon stroke of the rod in opposite directions. A collet operatively connects the second piston rod to the kickout arm when the loop is at rest and disconnects said arm therefrom when the loop is being driven.

Abstract: An apparatus is provided for singly discharging laterally aligned cylindrical workpieces from the lower end of an inclined rollway. A rocker having a pivot intermediate its ends is disposed beneath the rollway and has a stop pin pivotally attached to the end of the rocker which is adjacent the lower end of the rollway and an index pin pivotally attached to the end of the rocker which is adjacent the upper end of the rollway. Sleeves are provided to receive the stop and index pins for guiding alternate advance and retract movements thereof into and out of positions projecting from the rollway in the path of the workpieces as the rocker is oscillated about its pivot.

Abstract: An apparatus for adjusting the stroke length of a crank rod includes a pair of plates having adjoining broad faces mounted on one of the faces of a flywheel. A crankpin or other means is located on the exposed part of the outer plate for connection of the crank rod. One of the plates has a spline member which is located off center with respect to the flywheel axis. The other plate has a grooved portion mateable with the spline member. The outer plate is detachably connected to the inner one and may be rotated with respect thereto, and then re-connected to provide positive change of the stroke length of the crank rod.

Abstract: A device for skimming floating material from a body of liquid, particularly useful with a pipe galvanizing apparatus for skimming dross from a zinc bath. The device includes paddles pivoted to a reciprocating carriage for dragging floating material to an edge of the vessel. The paddles pivot to positions in which their faces lie parallel with the direction of carriage movement to avoid pushing material back toward the interior of the vessel during return strokes of the carriage.