Abstract: A method for selecting a final model for detecting cells of interest in image datasets includes dividing a curated image dataset into a training set, a validation set, and a testing set where each image in the curated image dataset has been labeled as positive or negative for a cell of interest. The method trains each model of an ensemble of neural networks using the training and validation sets. Next, each model of the ensemble is tested using the testing set and the predictions of the ensemble are combined. The combined prediction is compared to the label and the method determines whether the combined prediction satisfies a pre-determined level of detection (LOD). If so, the method outputs the ensemble as a final ensemble. If not, the method modifies a hyperparameter of at least one of the models of the ensemble until the combined prediction satisfies the pre-determined LOD.

Abstract: Provided herein are genetically engineered mammalian (e.g., human) cells that express one or more transgenes at a sustained expression level. Also provided are methods of making and using the cells.

Abstract: Provided herein are enriched populations of ventricular compact cardiomyocytes and enriched populations of mature ventricular or atrial cardiomyocytes, as well as methods of generating the enriched cell populations and methods of using the enriched cell populations in regenerative cardiac cell therapies.

Abstract: A method for selecting a final model for detecting cells of interest in image datasets includes dividing a curated image dataset into a training set, a validation set, and a testing set where each image in the curated image dataset has been labeled as positive or negative for a cell of interest. The method trains each model of an ensemble of neural networks using the training and validation sets. Next, each model of the ensemble is tested using the testing set and the predictions of the ensemble are combined. The combined prediction is compared to the label and the method determines whether the combined prediction satisfies a pre-determined level of detection (LOD). If so, the method outputs the ensemble as a final ensemble. If not, the method modifies a hyperparameter of at least one of the models of the ensemble until the combined prediction satisfies the pre-determined LOD.

Abstract: A pilot assembly includes a body portion including an outer surface and an opening defined in the outer surface. A pilot is configured for extending through an alignment hole in a sheet of material and is coupled with the body portion. A shaft of the pilot extends through the opening and beyond the outer surface. A stripper includes a bushing and a resilient biasing member. The bushing is configured for moving with respect to the main body portion and the pilot to push the sheet of material off of the pilot. The resilient biasing member is situated within the body portion and is compressed when the bushing engages the sheet of material.

Abstract: A pilot assembly includes a body portion including an outer surface and an opening defined in the outer surface. A pilot is configured for extending through an alignment hole in a sheet of material and is coupled with the body portion. A shaft of the pilot extends through the opening and beyond the outer surface. A stripper includes a bushing and a resilient biasing member. The bushing is configured for moving with respect to the main body portion and the pilot to push the sheet of material off of the pilot. The resilient biasing member is situated within the body portion and is compressed when the bushing engages the sheet of material.

Abstract: Metals for use in glass-making furnaces and which are susceptible to oxidation at furnace operating temperatures, especially iridium or molybdenum, are protected by applying at least (200) microns thickness of a coating formed of metal oxide particles in a metal oxide matrix. Oxidation, measured by weight loss, is significantly reduced.

Abstract: Part of the surface of a metallic-oxide refractory ceramic part, such as a fusion-cast refractory block, is treated using a high energy beam, to remove portions of the surface. A metal film may then be sprayed onto the treated surface of the ceramic part, for example to provide protection against erosion/corrosion in glass furnaces. Excellent adhesion between metal and ceramic can be attained.

Abstract: A gas leak detection system and method for detecting the presence of a leaking gas, such as helium. The apparatus consists of a housing containing an extended nozzle with a tip at the end. The housing contains an eccentric motor. The presence of a target gas is detected through a sensing element located in the leak detector, which sends a signal to the CPU. When the amount of the gas leak is over a threshold, the CPU sends a signal to an eccentric motor located in the housing causing the handle of the instrument to vibrate, thereby notifying the user that a leak has been detected. A signal is also preferably sent from the CPU to a light emitting diode (LED), as to visually notify the user as well, and to a speaker to audibly alert the user, both the vibrations and audio alarms can be turned on/off by a switch.

Abstract: An output buffer provides a stable, predetermined low voltage differential over power supply, temperature, and process variations yet has a high speed of operation. More particularly, a data path of an output buffer includes an emitter-coupled differential amplifier followed by an output section of two level-shifting emitter followers. A predetermined operating current biases the differential amplifier for unsaturated operation and a reference current biases the output section for unsaturated operation. The data path remains unencumbered by compensation circuitry to preserve high speed operation. Instead, a voltage compensator biases the differential amplifier to compensate, at least in part, for variations in a supply voltage. In addition, a variable biasing current to the voltage compensator with a predetermined temperature coefficient may further temperature compensate the differential amplifier.

Abstract: Amino acid sequences substantially identical to the C-terminal end of an .alpha.-S2 casein precursor one shown to act as growth promoters.Disclosed are sequences from Bovine .alpha.-S2 casein including the 9 C-terminal amino acids.LysValIlEProTyrValArgTyrLeu (SEQ ID NO:1)Also disclosed are foodstuffs and medicaments comprising the peptides of the invention and a method of producing same.

Abstract: A lure for attracting and engaging a fish. The inventive device includes a main body shaped so as to resemble a crab. A bill extends from a forward end of the body for hydrodynamically biasing the body in response to movement of the lure. A keel extends from a bottom of the body to maintain stability of the lure when in motion. A hook extends from a rear of the body for engaging a fish attracted to the lure. A weight can be positioned within the keel so as to cause the body to assume a predetermined orientation within water.