Abstract: The present invention relates to chimeric immune receptor molecules for reducing or eliminating tumors. The chimeric receptors are composed a C-type lectin-like natural killer cell receptor, or a protein associated therewith, fused to an immune signaling receptor containing an immunoreceptor tyrosine-based activation motif. Methods for using the chimeric receptors are further provided.

Abstract: Among other things, the present disclosure provides designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc.

Abstract: A structure of an electric or hybrid vehicle includes a floor, a battery container secured beneath the floor, and a compressed foam plate arranged between the battery container and the floor.

Abstract: A handle assembly for an infant carrier is provided. The handle assembly allows the handle to be oriented in one of a plurality of positions, such as a stroller position, and infant carrier position and a car seat position. The handle assembly may include a locking mechanism allowing a handle extension to be extended only when the handle rotated to the stroller position. The handle assembly may also include a blocking mechanism that prevents the handle from rotating from the stroller position if the handle is extended.

Abstract: Among other things, the present disclosure relates to designed oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide altered splicing of a transcript. In some embodiments, provided oligonucleotide compositions have low toxicity. In some embodiments, provided oligonucleotide compositions provide improved protein binding profiles. In some embodiments, provided oligonucleotide compositions have improved delivery. In some embodiments, provided oligonucleotide compositions have improved uptake. In some embodiments, the present disclosure provides methods for treatment of diseases using provided oligonucleotide compositions.

Abstract: An ear-worn hearing device comprises a housing comprising an end portion configured for at least partial insertion into a user's ear, the housing comprises an opening at the end portion. A removable acoustic transducer assembly is disposed in the opening at the end portion. The transducer assembly is configured for removal from the end portion of the ear-worn hearing device housing. The transducer assembly comprises an acoustic transducer, a support structure mechanically coupled to the acoustic transducer, the open portion of the acoustic transducer acoustically coupled with an opening of the support structure; and a releasable retention structure configured to removably retain the transducer assembly in a cavity of the ear-worn hearing device housing. In some implementations a vibration isolation structure isolates the acoustic transceiver from vibration. In certain implementations, the transducer assembly includes an extraction feature that allows extraction from the end portion of the ear-worn device.

Abstract: Among other things, the present disclosure provides designed APOC3 oligonucleotides, compositions, and methods thereof. In some embodiments, provided oligonucleotide compositions provide improved single-stranded RNA interference and/or RNase H-mediated knockdown. Among other things, the present disclosure encompasses the recognition that structural elements of oligonucleotides, such as base sequence, chemical modifications (e.g., modifications of sugar, base, and/or internucleotidic linkages) or patterns thereof, conjugation with additional chemical moieties, and/or stereochemistry [e.g., stereochemistry of backbone chiral centers (chiral internucleotidic linkages)], and/or patterns thereof, can have significant impact on oligonucleotide properties and activities, e.g., RNA interference (RNAi) activity, stability, delivery, etc.

Abstract: Improved battery separators, base films or membranes, batteries, cells, devices, systems, vehicles, and/or methods of making and/or using such separators, films or membranes, batteries, cells, devices, systems, vehicles, and/or methods of enhancing battery or cell charge rates, charge capacity, and/or discharge rates, and/or methods of improving batteries, systems including such batteries, vehicles including such batteries and/or systems, and/or the like; biaxially oriented porous membranes, composites including biaxially oriented porous membranes, biaxially oriented microporous membranes, biaxially oriented macroporous membranes, battery separators with improved charge capacities and the related methods and methods of manufacture, methods of use, and the like; flat sheet membranes, liquid retention media; dry process separators; biaxially stretched separators; dry process biaxially stretched separators having a thickness range between about 5 ?m and 50 ?m, preferably between about 10 ?m and 25 ?m, having imp

Abstract: The present disclosure relates to supported catalyst systems for olefin polymerization, catalyst system precursors, methods of producing the precursors and catalyst systems and polyolefins formed from the catalyst systems.

Abstract: Generating a recipe for controlling a polishing system includes receiving a target removal profile that includes a target thickness to remove for a plurality of locations on a substrate that are angularly distributed around the substrate, and storing a first function defining a polishing rate for a zone from a plurality of pressurizable zones of a carrier head that are angularly distributed around a the carrier head. The first function defines polishing rates as a function of pressures. For each particular zone of the plurality of zones a recipe defining a pressure for the particular zone over time is calculated by calculating an expected thickness profile after polishing using the first function, and minimizing a cost function that incorporates a first term representing a difference between the expected thickness profile and a target thickness profile.

Abstract: The disclosed technology enables automated parking of an autonomous vehicle. An example method of performing automated parking for a vehicle comprises obtaining, from a plurality of global positioning system (GPS) devices located on or in an autonomous vehicle, a first set of location information that describes locations of multiple points on the autonomous vehicle, where the first set of location information are associated with a first position of the autonomous vehicle, determining, based on the first set of location information and a location of the parking area, a trajectory information that describes a trajectory for the autonomous vehicle to be driven from the first position of the autonomous vehicle to a parking area, and causing the autonomous vehicle to be driven along the trajectory to the parking area by causing operation of one or more devices located in the autonomous vehicle based on at least the trajectory information.

Abstract: A method for chemical mechanical polishing includes receiving an angular removal profile for a carrier head and an angular thickness profile of a substrate. Prior to polishing the substrate, a desired angle of the carrier head relative to the substrate is selected for loading the substrate into the carrier head. Selecting the desired angle is performed based on a comparison of the angular removal profile for the carrier head and the angular thickness profile of the substrate to reduce angular non-uniformity in polishing. The carrier head is rotated to receive the substrate at the desired angle, the substrate is transferred to the carrier head and loaded in the carrier head with the carrier head at the desired angle relative to the substrate, and the substrate is polished.

Abstract: A system, device and method for nail care is provided. The nail care system includes a shaping system, a polish removal system and/or a cuticle management system; a vision system; a nail polish application system; and a mobility system. The nail system may further include an accelerated drying system, a hand massage system, a nail identification/diagnosis/estimation of conditions system, an enclosure, a hand/foot rest system, a computer software system, a computer hardware system, a cartridge/pod system, and a multi-tool system. Related apparatuses, techniques and articles are also described.

Abstract: A structure of an electric or hybrid vehicle includes a floor, a battery container secured beneath the floor, and a compressed foam plate arranged between the battery container and the floor.

Abstract: A wiper blade and a wiper. The wiper blade comprises a wiping strip and a connection structure, the connection structure comprising: an adapter fixed to the wiping strip, the adapter comprising a first side part and a second side part which are opposite each other, with a first surface and a second surface being disposed on the first side part and the second side part respectively; a connector, the interior of the connector having an opening, a foolproofing part facing the second surface, and a hole in communication with the opening; when the connector is fitted to the adapter in an opposite direction, the first surface obstructs the foolproofing part and the shaft cannot be hinged into the hole via the opening. The foolproofing part can prevent a wiper arm from being fitted to the wiper blade incorrectly.

Abstract: A wiper blade and a wiper. The wiper blade comprises a wiping strip and a connection structure, the connection structure comprising: an adapter fixed to the wiping strip, the adapter comprising a first side part and a second side part which are opposite each other, with a first surface and a second surface being disposed on the first side part and the second side part respectively; a connector, the interior of the connector having an opening, a foolproofing part facing the second surface, and a hole in communication with the opening; when the connector is fitted to the adapter in an opposite direction, the first surface obstructs the foolproofing part and the shaft cannot be hinged into the hole via the opening. The foolproofing part can prevent a wiper arm from being fitted to the wiper blade incorrectly.

Abstract: The present invention pertains to a dry cement formulation for cementing earth boreholes, in particular oil, gas and/or terrestrial heat boreholes, containing a) about 20 to 99.9 wt. % cement, b) about 0 to 65 wt. % powdered quartz/or quartz dust, c) about 0.1 to 30 wt. % water-redispersible dispersion powder, and d) about 0 to 20 wt. % further additives. Furthermore, the invention pertains to the use of the dry cement formulation for preparing a cement slurry as well as to the use of water-redispersible dispersion powders in a cement slurry for cementing earth boreholes, wherein the cement slurries can be used for reducing the water loss of the cement slurry, for reducing the gas and/or water penetration and/or for sealing off the gas and/or water channels by means of the cement slurry which has been introduced into the borehole and has set.

Abstract: A vehicle including at least one glass pane, bodywork, and at least one layer of viscoelastic material interposed between the glass pane and the bodywork.

Abstract: A vehicle including at least one glass pane, bodywork, and at least one layer of viscoelastic material interposed between the glass pane and the bodywork.

Abstract: An adjustable illumination apparatus includes an illumination source having a housing carrying an illuminatable element. A mount is adapted to surround an imaging system lens. An extensible and retractable support has first and second ends mounts the illumination source to the mount. First and second connections movably couple the first and second ends of the support to the mount and the illumination source. The support includes one or more telescoping legs or a cross link bar assembly. In one aspect, the apparatus includes multiple illumination sources. The connections allow each illumination source to be independently positioned relative to other illumination sources. The illuminatable elements in each illumination source may be independently controlled.