Abstract: Provided herein are methods and systems for detecting genetic variants from sequencing data. The methods and systems provided herein can be useful for identifying the presence or absence of clinically actionable variants from a sequencing data set and reporting the clinically actionable variants to a user of the methods and systems.

Abstract: Provided herein are methods and systems for detecting genetic variants from sequencing data. The methods and systems provided herein can be useful for identifying the presence or absence of clinically actionable variants from a sequencing data set and reporting the clinically actionable variants to a user of the methods and systems.

Abstract: An internal combustion engine is provided. The internal combustion engine includes an engine block having at least one cylinder. The internal combustion engine includes a cylinder head engaged with the engine block. The internal combustion engine includes a pre-chamber assembly associated with the cylinder head. The pre-chamber assembly includes a pre-chamber in fluid communication with a main combustion chamber. The pre-chamber assembly includes a fuel supply unit in fluid communication with the pre-chamber to selectively supply fuel to the pre-chamber. The pre-chamber assembly includes an auxiliary unit configured to produce oxygen and hydrogen. The auxiliary unit is in fluid communication with the pre-chamber to supply oxygen to the pre-chamber and in fluid communication with the main combustion chamber to supply hydrogen to the main combustion chamber. The pre-chamber assembly includes an ignition unit associated with the pre-chamber to selectively ignite a mixture of fuel and oxygen in the pre-chamber.

Abstract: A method for reforming fuel for an engine is disclosed. The method comprising heating, in a non-catalytic combustor, a mixture of fuel and air at a temperature in a range from 550K to 950K, to partially oxidize the fuel to generate one or more free radicals. The one or more free radicals constitute reformed fuel. Further, the reformed fuel is supplied to the engine.

Abstract: An internal combustion engine is provided. The internal combustion engine includes an engine block having at least one cylinder. The internal combustion engine includes a cylinder head engaged with the engine block. The internal combustion engine includes a pre-chamber assembly associated with the cylinder head. The pre-chamber assembly includes a pre-chamber in fluid communication with a main combustion chamber. The pre-chamber assembly includes a fuel supply unit in fluid communication with the pre-chamber to selectively supply fuel to the pre-chamber. The pre-chamber assembly includes an auxiliary unit configured to produce oxygen and hydrogen. The auxiliary unit is in fluid communication with the pre-chamber to supply oxygen to the pre-chamber and in fluid communication with the main combustion chamber to supply hydrogen to the main combustion chamber. The pre-chamber assembly includes an ignition unit associated with the pre-chamber to selectively ignite a mixture of fuel and oxygen in the pre-chamber.

Abstract: A system for accomplishing engine exhaust braking and exhaust gas recirculation for an engine having an exhaust manifold and a plurality of exhaust valves per cylinder during a four stroke engine cycle is provided. The system includes an actuation device operable to provide valve actuation of a single exhaust valve for an exhaust braking event and an exhaust gas recirculation event. The exhaust valve is not completely closed during the exhaust braking event and the exhaust gas recirculation event. The exhaust braking event includes actuating a single exhaust valve beginning during a second half of a compression stroke and a first half of an expansion stroke, and closing the exhaust valve beginning during a second half of an exhaust stroke. The exhaust gas recirculation event includes reactuating the exhaust valve beginning during a first half of an intake stroke, and closings the exhaust valve beginning during a second half of the intake stroke.

Abstract: A system for accomplishing engine exhaust braking and exhaust gas recirculation for an engine having an exhaust manifold and a plurality of exhaust valves per cylinder during a four stroke engine cycle is provided. The system includes an actuation device operable to provide valve actuation of a single exhaust valve for an exhaust braking event and an exhaust gas recirculation event. The exhaust valve is not completely closed during the exhaust braking event and the exhaust gas recirculation event. The exhaust braking event includes actuating a single exhaust valve beginning during a second half of a compression stroke and a first half of an expansion stroke, and closing the exhaust valve beginning during a second half of an exhaust stroke. The exhaust gas recirculation event includes reactuating the exhaust valve beginning during a first half of an intake stroke, and closings the exhaust valve beginning during a second half of the intake stroke.

Abstract: A turbocharged internal combustion engine assembly with exhaust gas recirculation (EGR) includes an air compressor driven by an exhaust turbine, an EGR line that diverts exhaust gases from an exhaust line leading from the engine to an air intake line leading to the engine from the compressor, and a combustion bypass line that conveys compressed air from the compressor to the exhaust turbine without combustion. A pressure adjusting feature disposed along at least one of the air intake line and the exhaust line maintains the pressure at the turbine inlet below the pressure at the compressor outlet and above the pressure at the air inlet of the engine. Examples of suitable pressure adjusting features include a venturi placed in the air intake line at the second point, a power turbine located along the exhaust line downstream of the exhaust turbine, a split exhaust manifold feeding unequal turbine inlets, and an orifice located along the exhaust line between the EGR line and the bypass line.

Abstract: A turbocharged internal combustion engine assembly with exhaust gas recirculation (EGR) includes an air compressor driven by an exhaust turbine, an EGR line that diverts exhaust gases from an exhaust line leading from the engine to an air intake line leading to the engine from the compressor, and a combustion bypass line that conveys compressed air from the compressor to the exhaust turbine without combustion. A pressure adjusting feature disposed along at least one of the air intake line and the exhaust line maintains the pressure at the turbine inlet below the pressure at the compressor outlet and above the pressure at the air inlet of the engine. Examples of suitable pressure adjusting features include a venturi placed in the air intake line at the second point, a power turbine located along the exhaust line downstream of the exhaust turbine, a split exhaust manifold feeding unequal turbine inlets, and an orifice located along the exhaust line between the EGR line and the bypass line.