Patents by Inventor Charlie E. Strauss

Charlie E. Strauss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11739318
    Abstract: Biosensors including a nucleic acid encoding a PcaU protein, a PobR protein, a CatM protein, a PcaR protein, or a TphR protein are provided. In some examples, the biosensors include a promoter regulated by the sensed molecule operably linked to a reporter gene. The biosensors may be included in a vector or in cells including one or more of the biosensors or vectors. Modified chorismate pyruvate lyase (UbiC) and modified paraoxonase (PON1) proteins including one or more amino acid substitutions are provided. Finally, methods of selecting biocatalysts with increased activity including transforming a library of cells expressing a biosensor with one or more nucleic acids encoding one or more mutations in a gene involved in a biosynthesis pathway, determining activity of the reporter protein; and selecting a cell with increased reporter protein activity as expressing a biocatalyst with increased activity are provided.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: August 29, 2023
    Assignee: Triad National Security, LLC
    Inventors: Ramesh K. Jha, Charlie E. Strauss, Taraka Dale
  • Patent number: 11084794
    Abstract: The present disclosure provides improved methods for controlled cyclization of peptoid dimers to form N,N?-2,5-diketopiperazines (N,N?-2,5-DKPs) with significant selectivity. In at least some examples, selectivity is based on a serendipitous conglomeration of slow exchange of amide rotamers, steric repulsion from the degree of ?-substitution, and the geometric bulk of an amine nucleophile. By varying reaction conditions, the selectivity of the reaction and formation of a particular N,N?-2,5-DKP can be switched. The cyclization works in the presence of a variety of protection groups and diverse functionalities. The teachings herein provide techniques for synthesizing N,N?-2,5-DKPs that can be readily docked with drug candidates for shuttling across the blood brain barrier. This method provides a facile way to produce substituted DKPs containing groups ready for post-modification to include docking drug candidates.
    Type: Grant
    Filed: October 30, 2019
    Date of Patent: August 10, 2021
    Assignee: Triad National Security, LLC
    Inventors: Robert F. Williams, Paul William Peterson, Robert David Gilbertson, Jurgen G. Schmidt, Charlie E. Strauss
  • Publication number: 20200131140
    Abstract: The present disclosure provides improved methods for controlled cyclization of peptoid dimers to form N,N?-2,5-diketopiperazines (N,N?-2,5-DKPs) with significant selectivity. In at least some examples, selectivity is based on a serendipitous conglomeration of slow exchange of amide rotamers, steric repulsion from the degree of ?-substitution, and the geometric bulk of an amine nucleophile. By varying reaction conditions, the selectivity of the reaction and formation of a particular N,N?-2,5-DKP can be switched. The cyclization works in the presence of a variety of protection groups and diverse functionalities. The teachings herein provide techniques for synthesizing N,N?-2,5-DKPs that can be readily docked with drug candidates for shuttling across the blood brain barrier. This method provides a facile way to produce substituted DKPs containing groups ready for post-modification to include docking drug candidates.
    Type: Application
    Filed: October 30, 2019
    Publication date: April 30, 2020
    Applicant: Triad National Security, LLC
    Inventors: Robert F. Williams, Paul William Peterson, Robert David Gilbertson, Jurgen G. Schmidt, Charlie E. Strauss
  • Publication number: 20170029812
    Abstract: Disclosed herein are methods of identifying polymers having particular biological or physical characteristics from in vivo generated libraries of polymers. Methods of generating in vivo polymer libraries are also described. Polymers identified using the methods of the invention are also described.
    Type: Application
    Filed: January 28, 2015
    Publication date: February 2, 2017
    Inventors: Jennifer S. Martinez, Devin W. Close, Antonietta M. Lillo, Eva Rose Murdock Balog, Csaba Kiss, Reginaldo C. Rocha, Andrew R.M. Bradbury, Koushik Ghosh, Prakash Sista, Hsing-Lin Wang, Charlie E. Strauss
  • Patent number: 5689335
    Abstract: Apparatus and method for heterodyne-generated, two-dimensional detector array using a single detector. Synthetic-array heterodyne detection, permits a single-element optical detector to behave as though it were divided into an array of separate heterodyne detector elements. A fifteen-element synthetic array has successfully been experimentally realized on a single-element detector, permitting all of the array elements to be read out continuously and in parallel from one electrical connection. A CO.sub.2 laser and a single-element HgCdTe photodiode are employed. A different heterodyne local oscillator frequency is incident upon the spatially resolvable regions of the detector surface. Thus, different regions are mapped to different heterodyne beat frequencies. One can determine where the photons were incident on the detector surface even though a single electrical connection to the detector is used.
    Type: Grant
    Filed: October 10, 1995
    Date of Patent: November 18, 1997
    Assignee: The Regents of the University of California
    Inventor: Charlie E. Strauss