Abstract: A system of interlocks for controlling flow of low temperature process streams in a manufacturing process through a cold box to equipment not specified for such temperatures by opening and closing valves and stopping pumps. At least one interlock affects streams heated in the cold box. At least one interlock affects the streams cooled in the cold box. The interlocks are activated due to temperature determinations of process lines by temperature sensors and automatically send a signal to predetermined controllers depending on the process line with the low temperature in order to prevent exposure of equipment to low temperatures while preventing the shutdown of the cold box.