Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.

Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.

Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.

Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.

Abstract: Provided herein are methods for identifying the presence or absence of a polypeptide variance between different biological samples and corresponding methods for generating a high-throughput screen to rapidly identify variances of one or more polypeptides in different biological samples. In particular, a variance in a post-translational modification on a particular polypeptide in the biological samples can be identified, such as the presence or absence of a polypeptide having an attached phosphoryl moiety, for example. In these methods, a catalytically inactivated enzyme (i.e. bindingzyme) is utilized as a substrate-specific binding protein. These bindingzymes can bind to one or more substrates in biological samples and a bound substrate can act as a marker to distinguish one sample from another. These methods also are useful for isolating substrates for their identification, for the detection of substrates in a sample, and for the discovery and development of ethical drugs.

Abstract: A method for discovery of a polymorphism in a population is provided. The method includes the steps of obtaining samples of body tissue or fluid from a plurality of organisms; isolating a biopolymer from each sample; pooling each isolated biopolymer; optionally amplifying the amount of biopolymer; cleaving the pooled biopolymers to produce fragments thereof; obtaining a mass spectrum of the resulting fragments; and comparing the frequency of each fragment to identify fragments present in amounts lower than the average frequency, thereby identifying any polymorphisms.

Abstract: Processes and methods for creating a database of genomic samples from healthy human donors, methods that use the database to identify and correlate polymorphic genetic markers and other markers with diseases and conditions are provided.