Patents by Inventor Charlly Kao

Charlly Kao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF DIAGNOSING AND TREATING ANXIETY DISORDER
    Publication number: 20240100036
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 28, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING CONDUCT DISORDER
    Publication number: 20240075022
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 30, 2023
    Publication date: March 7, 2024
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Methods of diagnosing and treating conduct disorder
    Patent number: 11806340
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: October 27, 2021
    Date of Patent: November 7, 2023
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING TOURETTE SYNDROME
    Publication number: 20220296582
    Abstract: Methods and uses for diagnosing and treating Tourette syndrome are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: April 6, 2022
    Publication date: September 22, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING CONDUCT DISORDER
    Publication number: 20220117953
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 27, 2021
    Publication date: April 21, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING ANXIETY DISORDER
    Publication number: 20220117954
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: October 28, 2021
    Publication date: April 21, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF LYMPHATIC SYSTEM DISORDERS
    Publication number: 20220112558
    Abstract: Compositions and methods for the diagnosis and treatment of lymphatic anomaly are disclosed.
    Type: Application
    Filed: September 9, 2019
    Publication date: April 14, 2022
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Yoav Dori, Dong Li, Michael March, Charlly Kao, Christoph Seiler
  • Methods of diagnosing and treating Tourette syndrome
    Patent number: 11298347
    Abstract: Methods and uses for diagnosing and treating Tourette syndrome are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: March 4, 2020
    Date of Patent: April 12, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Methods of diagnosing and treating autism
    Patent number: 11219617
    Abstract: Methods for diagnosing and treating autism spectral disorders are encompassed. In one embodiment, a patient is diagnosed as having autism spectral disorder if at least one CNV in an mGluR network gene is found in a patient sample. Patients with at least one mGluR network gene CNV are effectively treated with (+)-5-oxo-Dprolinepiperidinamide monohydrate (NS-105).
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: January 11, 2022
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Tara Wenger, Charlly Kao, Dexter Hadley, Zhi-liang Wu, Joseph Glessner
  • Methods of diagnosing and treating conduct disorder
    Patent number: 11179378
    Abstract: Methods for diagnosing and treating conduct disorder are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: November 23, 2021
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Methods of diagnosing and treating anxiety disorder
    Patent number: 11173153
    Abstract: Methods and uses for diagnosing and treating anxiety disorders are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Grant
    Filed: September 7, 2016
    Date of Patent: November 16, 2021
    Assignee: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ANOREXIA NERVOSA AND BINGE EATING DISORDER
    Publication number: 20210267958
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Application
    Filed: February 12, 2021
    Publication date: September 2, 2021
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao
  • NOVEL TOPICAL FORMULATION FOR INTRADERMAL APPLICATION AND USES THEREOF
    Publication number: 20210251973
    Abstract: The invention provides compositions comprising a topical formulation of donepezil and methods of use thereof for intradermal applications.
    Type: Application
    Filed: August 29, 2019
    Publication date: August 19, 2021
    Inventors: Hakon HAKONARSON, Charlly KAO, Edward T. KISAK, John M. NEWSAM, Avadhesh S. KUSHWAHA
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ATTENTION DEFICIT DISORDER AND 22Q SYNDROME
    Publication number: 20210205288
    Abstract: This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.
    Type: Application
    Filed: December 17, 2020
    Publication date: July 8, 2021
    Applicant: THE CHILDREN'S HOSPITAL OF PHILADELPHIA
    Inventors: Hakon Hakonarson, Charlly Kao
  • Nonselective metabotropic glutamate receptor activators for treatment of anorexia nervosa and binge eating disorder
    Patent number: 10918632
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Grant
    Filed: September 6, 2017
    Date of Patent: February 16, 2021
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao
  • Nonselective metabotropic glutamate receptor activators for treatment of attention deficit disorder and 22Q syndrome
    Patent number: 10869861
    Abstract: This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: December 22, 2020
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao
  • METHODS OF DIAGNOSING AND TREATING TOURETTE SYNDROME
    Publication number: 20200306237
    Abstract: Methods and uses for diagnosing and treating Tourette syndrome are encompassed, wherein diagnosis and treatment may be based upon an assessment of genetic alterations in metabotropic glutamate receptor (mGluR) network genes and wherein treatment is with nonspecific activators of mGluRs such as fasoracetam.
    Type: Application
    Filed: March 4, 2020
    Publication date: October 1, 2020
    Inventors: Hakon Hakonarson, Charlly Kao
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ANOREXIA NERVOSA AND BINGE EATING DISORDER
    Publication number: 20190298706
    Abstract: This application relates to methods of diagnosing and treating anorexia nervosa (AN) and binge eating disorder (BED) with a nonselective activator of metabotropic glutamate receptors (mGluRs).
    Type: Application
    Filed: September 6, 2017
    Publication date: October 3, 2019
    Inventors: Hakon Hakonarson, Charlly Kao
  • Methods of treating autoimmune conditions in patients with genetic variations in DcR3 or in a DcR3 network gene
    Patent number: 10407725
    Abstract: The present disclosure relates to methods of treating autoimmune conditions in patients who have genetic alterations in the TNFRSF6B gene, which codes for the decoy receptor 3 protein (DcR3), for example that reduce the expression, secretion, or ligand binding activity of DcR3. For example, in some embodiments, the conditions may be treated with molecules that inhibit the activity of DcR3 ligands such as LIGHT, TL1A, and FasL, such as anti-LIGHT, anti-TL1A, and anti-FasL antibodies, or inhibitors of the non-canonical NF-?B pathway.
    Type: Grant
    Filed: August 19, 2016
    Date of Patent: September 10, 2019
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao, Christopher Cardinale, Rahul Pandey, Yun Rose Li
  • NONSELECTIVE METABOTROPIC GLUTAMATE RECEPTOR ACTIVATORS FOR TREATMENT OF ATTENTION DEFICIT DISORDER AND 22Q SYNDROME
    Publication number: 20180110767
    Abstract: This application relates to methods of treating attention deficit hyperactivity disorder (ADHD), 22q deletion and/or duplication syndrome, and co-morbidities with a nonselective activator of metabotropic glutamate receptors, such as fasoracetam, for example, in subjects having a genetic alteration in at least one metabotropic glutamate receptor (mGluR) network gene.
    Type: Application
    Filed: December 21, 2017
    Publication date: April 26, 2018
    Applicant: The Children's Hospital of Philadelphia
    Inventors: Hakon Hakonarson, Charlly Kao