Abstract: A method for autonomously identifying symptom terms in free running text data includes the acts of defining a plurality of symptom terms associated with a particular pathology or therapeutic substance or procedure, labeling in a text data set any defined symptom terms and associating a tag indicating any of a positive, negative, or other status with relation to the labeled symptom term, and processing with a natural language processing algorithm multiple different subsets of the text data containing labeled symptom terms to identify a frequency of occurrence of a symptom term and to improve identification accuracy.

Abstract: A method for autonomously identifying symptom terms in free running text data includes the acts of defining a plurality of symptom terms associated with a particular pathology or therapeutic substance or procedure, labeling in a text data set any defined symptom terms and associating a tag indicating any of a positive, negative, or other status with relation to the labeled symptom term, and processing with a natural language processing algorithm multiple different subsets of the text data containing labeled symptom terms to identify a frequency of occurrence of a symptom term and to improve identification accuracy.

Abstract: A method for enriching a population of somatic mammary stem cells or mammary tumor stem cells based on low-density lipoprotein receptor-related protein 6 (LRP6). Also included are methods for screening for LRP6 modulators, as well as methods for reducing Wnt signaling, for treating Wnt signaling-related diseases, for detecting mammary basal-like cells, for diagnosing basal-like breast cancer, and for inhibiting proliferation of a tumor expressing LRP6, and compositions thereof.

Abstract: It is disclosed here that low density lipoprotein receptor-related protein 5 (LRP5) is a cell surface marker for somatic mammary stem cells and mammary tumor stem cells. The disclosure here provides new tools for enriching somatic mammary stem cells and mammary tumor stem cells. Methods of screening for agents that modulate LRP5 activity, of treating mammary tumor or breast cancer, of monitoring somatic mammary stem cells and mammary tumor stem cells in vivo are also provided, and of assessing prognosis of human breast cancer.

Abstract: A method for enriching a population of somatic mammary stem cells or mammary tumor stem cells based on low-density lipoprotein receptor-related protein 6 (LRP6). Also included are methods for screening for LRP6 modulators, as well as methods for reducing Wnt signaling, for treating Wnt signaling-related diseases, for detecting mammary basal-like cells, for diagnosing basal-like breast cancer, and for inhibiting proliferation of a tumor expressing LRP6, and compositions thereof.

Abstract: It is disclosed here that low density lipoprotein receptor-related protein 5 (LRP5) is a cell surface marker for somatic mammary stem cells and mammary tumor stem cells. The disclosure here provides new tools for enriching somatic mammary stem cells and mammary tumor stem cells. Methods of screening for agents that modulate LRP5 activity, of treating mammary tumor or breast cancer, of monitoring somatic mammary stem cells and mammary tumor stem cells in vivo are also provided, and of assessing prognosis of human breast cancer.