Abstract: Disclosed are antibodies and antibody drug conjugates having an Fc region with substitutions resulting in essentially a silent Fc region. The antibodies and antibody drug conjugates described herein are useful for the depletion of cells and for the treatment of various hematopoietic diseases, metabolic disorders, cancers, e.g., acute myeloid leukemia (AML) and autoimmune diseases, among others. The compositions and methods described herein can be used to treat a disorder directly, for instance, by depleting, e.g., a population of CD45+ or CD117+ cancer cells or CD45+ autoimmune cells. The compositions and methods described herein can also be used to prepare a patient for hematopoietic stem cell transplant therapy and to improve the engraftment of hematopoietic stem cell transplants by selectively depleting endogenous hematopoietic stem cells prior to the transplant procedure.

Abstract: The invention provides a system (10) for a motor vehicle (100) that receives drive demand information (161S) indicative of an amount of drive demanded of a powertrain (129) of the vehicle (100), and controls an amount of drive torque applied by the powertrain (129) to one or more road wheels (111, 112, 114, 115) in dependence on the drive demand information (116S). The system also receives gradient information (11GS) relating to the driving surface and vehicle speed information (Sv). The control system, in dependence on the gradient and speed information, automatically causes a braking system (12d) to apply brake force to one or more of the wheels (111, 112, 114, 115) to prevent vehicle rollback, and adjusts the amount of brake force applied in dependence on the drive demand information (161S) to cause the amount of brake force applied to increase progressively as the amount of drive demand decreases.

Abstract: A vehicle control system for controlling at least one subsystem of a vehicle; the vehicle control system comprising: a subsystem controller for initiating control of the or each of the at least one vehicle subsystems in one of a plurality of baseline subsystem control modes by setting at least one control parameter of the or each of the at least one subsystems to a predetermined, stored, value or state applicable to that baseline subsystem control mode, each baseline subsystem control mode corresponding to one or more different driving conditions for the vehicle; and input means for permitting a user to provide an input to the control system, wherein, for at least one of the plurality of baseline subsystem control modes, the control system is configured to allow a user to define, via the input means, a user-configured subsystem control mode based on one said at least one baseline subsystem control mode by adjusting the value or state of at least one of said at least one control parameters to a value or state

Abstract: The invention provides a system (10) for a motor vehicle (100) that receives drive demand information (161S) indicative of an amount of drive demanded of a powertrain (129) of the vehicle (100), and controls an amount of drive torque applied by the powertrain (129) to one or more road wheels (111, 112, 114, 115) in dependence on the drive demand information (116S). The system also receives gradient information (11GS) relating to the driving surface and vehicle speed information (Sv). The control system, in dependence on the gradient and speed information, automatically causes a braking system (12d) to apply brake force to one or more of the wheels (111, 112, 114, 115) to prevent vehicle rollback, and adjusts the amount of brake force applied in dependence on the drive demand information (161S) to cause the amount of brake force applied to increase progressively as the amount of drive demand decreases.

Abstract: A motor vehicle controller configured to: receive a drive demand signal indicating an amount of net drive to be applied to one or more driving wheels of a vehicle, estimate a value of a parameter indicative of a surface coefficient of friction between one or more driving wheels and a driving surface, and apply a net torque to one or more wheels of a vehicle. The amount of net torque applied is determined in dependence at least in part on the received drive demand signal. The controller is configured to increase an amount of net torque applied to one or more driving wheels independently of the drive demand signal and to update an estimate of the parameter in dependence on a change in speed of the at least one driving wheel when the amount of net torque applied to the at least one driving wheel is increased.

Abstract: A motor vehicle controller that carries out a method which includes: receiving a signal indicative of a surface friction parameter, surface_friction, the surface friction parameter corresponding to a coefficient of friction between a road wheel and a driving surface; receiving a signal indicative of a position of an accelerator control with respect to an allowable range of positions, accel_ctrl_pos; determining a critical powertrain torque limit value PT_TQ_CRIT in dependence at least in part on the value of surface_friction; and providing a traction warning indication to a driver in dependence on the value of accel_ctrl_pos and PT_TQ_CRIT.

Abstract: A vehicle control system for controlling at least one subsystem of a vehicle; the vehicle control system comprising: a subsystem controller for initiating control of the or each of the at least one vehicle subsystems in one of a plurality of baseline subsystem control modes by setting at least one control parameter of the or each of the at least one subsystems to a predetermined, stored, value or state applicable to that baseline subsystem control mode, each baseline subsystem control mode corresponding to one or more different driving conditions for the vehicle; and input means for permitting a user to provide an input to the control system, wherein, for at least one of the plurality of baseline subsystem control modes, the control system is configured to allow a user to define, via the input means, a user-configured subsystem control mode based on one said at least one baseline subsystem control mode by adjusting the value or state of at least one of said at least one control parameters to a value or state

Abstract: A motor vehicle controller configured to: receive a drive demand signal indicating an amount of net drive to be applied to one or more driving wheels of a vehicle, estimate a value of a parameter indicative of a surface coefficient of friction between one or more driving wheels and a driving surface, and apply a net torque to one or more wheels of a vehicle. The amount of net torque applied is determined in dependence at least in part on the received drive demand signal. The controller is configured to increase an amount of net torque applied to one or more driving wheels independently of the drive demand signal and to update an estimate of the parameter in dependence on a change in speed of the at least one driving wheel when the amount of net torque applied to the at least one driving wheel is increased.

Abstract: A motor vehicle controller that carries out a method which includes: receiving a signal indicative of a surface friction parameter, surface_friction, the surface friction parameter corresponding to a coefficient of friction between a road wheel and a driving surface; receiving a signal indicative of a position of an accelerator control with respect to an allowable range of positions, accel_ctrl_pos; determining a critical powertrain torque limit value PT_TQ_CRIT in dependence at least in part on the value of surface_friction; and providing a traction warning indication to a driver in dependence on the value of accel_ctrl_pos and PT_TQ_CRIT.