Patents by Inventor Charlotte D'Hulst

Charlotte D'Hulst has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BIOSENSORS FOR DETECTING CHANGES IN THE LEVEL OF A NEUROTRANSMITTER IN THE CENTRAL NERVOUS SYSTEM
    Publication number: 20230358770
    Abstract: Provided herein are biosensors and methods for detecting one or more odorants associated with the levels, or a change in the levels, of one or more neurotransmitters in the central nervous system of a subject. In embodiments, provided are biosensors that comprise one or more populations of olfactory neurons, or cilia derived therefrom, wherein each population preferentially expresses a specific odorant receptor (OR). Also provided are biosensors comprising a cell or a population of cells engineered to express certain ORs; biosensors comprising certain isolated ORs; transgenic animals and tissues derived therefrom that preferentially express certain ORs; isolated cells or populations of cells engineered to express certain ORs; expression constructs for the preferential expression of certain ORs; and methods of using the biosensors, transgenic animals, tissues, cells, population of cells, and expression constructs disclosed herein.
    Type: Application
    Filed: September 22, 2021
    Publication date: November 9, 2023
    Inventors: Paul Feinstein, Charlotte D'Hulst
  • Biosensor exhibiting sensitivity to trinitrotoluene
    Patent number: 11255830
    Abstract: A biosensor for detecting trinitrotoluene (TNT) is disclosed. The biosensor has cells, such as olfactory sensory neurons (or cilia derived therefrom), that preferentially express a TNT-responsive odorant receptor protein.
    Type: Grant
    Filed: January 2, 2018
    Date of Patent: February 22, 2022
    Assignee: Research Foundation of the City University of New York
    Inventors: Paul Feinstein, Charlotte D'Hulst
  • DNA SEQUENCE THAT INCREASES ODORANT RECEPTOR REPRESENTATION IN THE OLFACTORY SYSTEM
    Publication number: 20200093104
    Abstract: A genetically modified vertebrate is provided that has an enhanced sense due to an over representation of a predetermined odorant receptor. The vertebrate is genetically modified by introduction of DNA that comprises at least four sequential repeats of a sequence whose primary structure is at least 90% homologous with ACATAACTTTTTAATGAGTCT (SEQ ID NO: 1). The DNA causes a nearby odorant receptor coding sequence to be over represented in a singular gene choice fashion relative to a corresponding vertebrate that lacks the DNA.
    Type: Application
    Filed: December 5, 2019
    Publication date: March 26, 2020
    Inventors: Paul Feinstein, Charlotte D'Hulst
  • DNA sequence that increases odorant receptor representation in the olfactory system
    Patent number: 10512253
    Abstract: A genetically modified vertebrate is provided that has an enhanced sense due to an over representation of a predetermined odorant receptor. The vertebrate is genetically modified by introduction of DNA that comprises at least four sequential repeats of a sequence whose primary structure is at least 90% homologous with ACATAACTTTTTAATGAGTCT (SEQ ID NO: 1). The DNA causes a nearby odorant receptor coding sequence to be over represented in a singular gene choice fashion relative to a corresponding vertebrate that lacks the DNA.
    Type: Grant
    Filed: August 3, 2016
    Date of Patent: December 24, 2019
    Assignee: Research Foundation of the City University of New York
    Inventors: Paul Feinstein, Charlotte D'Hulst
  • BIOSENSOR EXHIBITING SENSITIVITY TO TRINITROTOLUENE
    Publication number: 20190324004
    Abstract: A biosensor for detecting trinitrotoluene (TNT) is disclosed. The biosensor has cells, such as olfactory sensory neurons (or cilia derived therefrom), that preferentially express a TNT-responsive odorant receptor protein.
    Type: Application
    Filed: January 2, 2018
    Publication date: October 24, 2019
    Inventors: Paul Feinstein, Charlotte D'Hulst
  • DNA SEQUENCE THAT INCREASES ODORANT RECEPTOR REPRESENTATION IN THE OLFACTORY SYSTEM
    Publication number: 20180317465
    Abstract: A genetically modified vertebrate is provided that has an enhanced sense due to an over representation of a predetermined odorant receptor. The vertebrate is genetically modified by introduction of DNA that comprises at least four sequential repeats of a sequence whose primary structure is at least 90% homologous with ACATAACTTTTTAATGAGTCT (SEQ ID NO: 1). The DNA causes a nearby odorant receptor coding sequence to be over represented in a singular gene choice fashion relative to a corresponding vertebrate that lacks the DNA.
    Type: Application
    Filed: August 3, 2016
    Publication date: November 8, 2018
    Inventors: Paul Feinstein, Charlotte D'Hulst