Patents by Inventor Charlotte Mitchell

Charlotte Mitchell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pyrazolo '3,4-B! Pyridine Compounds And Their Use As Phosphodiesterase Type 4(Pde4) Inhibitors
    Publication number: 20080021058
    Abstract: The invention provides a compound of formula (I) or a salt thereof: wherein W is Ar, —CR4R5Ar or a group (y) or (y1), wherein Ar is (x) or (z): R1 is C1-4alkyl, C1-3fluoroalkyl or —CH2CH2OH. R2 is C2-6alkyl, C3-6cycloalkyl or —(CH2)n4-C3-6cycloalkyl; and R3 is optionally substituted C3-8cycloalkyl, optionally substituted mono-unsaturated-C5-7cycloalkenyl, an optionally substituted heterocyclic group (aa), (bb) or (cc) (in which Y is O, S, SO2, or NR10), or a bicyclic group (ee): These compounds are PDE4 inhibitors.
    Type: Application
    Filed: March 15, 2005
    Publication date: January 24, 2008
    Inventors: David Allen, Diane Coe, Caroline Cook, Michael Dowle, Christopher Edlin, Julie Hamblin, Martin Johnson, Paul Jones, Mika Lindvall, Charlotte Mitchell, Alison Redgrave, Naimisha Trivedi
  • Pyrazolo[3,4-b]pyridine compounds, and their use as pde4 inhibitors
    Publication number: 20070167485
    Abstract: The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is Et, n-Pr, i-Pr, C2fluoroalkyl, or —CH2CH2OH; R2 is H, Me, Et, n-Pr, i-Pr, C1-2fluoroalkyl, cyclopropyl or (cyclopropyl)methyl-; and NHR3 has the sub-formula (nhr3): wherein R3a is methyl or ethyl; R3b is H, methyl or ethyl; R3c is H, methyl or ethyl, R3d is H, methyl or ethyl, and R3e is H or methyl, provided that: (a) R3b is methyl or ethyl; and/or (b) R3c and R3d are independently methyl or ethyl; and provided that: (c) when R3c is ethyl and/or when R3d is ethyl and/or when R3e is methyl, then: R3a is methyl and/or R3b is hydrogen or methyl. These compounds are PDE4 inhibitors.
    Type: Application
    Filed: March 15, 2005
    Publication date: July 19, 2007
    Inventors: Diane Coe, Caroline Cook, Anthony Cooper, Christopher Edlin, Julie Hamblin, Martin Johnson, Paul Jones, Mika Lindvall, Charlotte Mitchell, Alison Redgrave, John Robinson
  • Pyrazolo[3,4-b] pyridine compounds, and their use as phosphodiesterase inhibitors
    Publication number: 20060089375
    Abstract: The invention relates to a compound of formula (I) or a salt thereof: wherein: R1 is C1-4alkyl, C1-3fluoroalkyl, —CH2CH2OH or —CH2CH2CO2C1-2alkyl; R2 is a hydrogen atom (H), methyl or C1fluoroalkyl; R3 is optionally substituted C3-8cycloalkyl or optionally substituted mono-unsaturated-C5-7cycloalkenyl or an optionally substituted heterocyclic group of sub-formula (aa), (bb) or (cc); in which n1 and n2 independently are 1 or 2; and in which Y is O, S, SO2, or NR10; or R3 is a bicyclic group (dd) or (ee): and wherein X is NR4R5 or OR5a. The compounds are phosphodiesterase (PDE) inhibitors, in particular PDE4 inhibitors. Also provided is the use of a compound of formula (I), or a pharmaceutically acceptable salt thereof, in the manufacture of a medicament for the treatment and/or prophylaxis of an inflammatory and/or allergic disease in a mammal such as a human, for example chronic obstructive pulmonary disease (COPD), asthma, or allergic rhinitis.
    Type: Application
    Filed: September 12, 2003
    Publication date: April 27, 2006
    Inventors: David Allen, Diane Coe, Caroline Cook, Michael Dowle, Christophen Edlin, Julie Hamblin, Martin Johnson, Paul Jones, Richard Knowles, Mika Lindvall, Charlotte Mitchell, Alison Redgrave, Peter Ward