Patents by Inventor Chase L. Beisel

Chase L. Beisel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integrated—ligand-responsive microRNAs
    Patent number: 9145555
    Abstract: The present application relates to nucleic acids that encode an miRNA and a sensor domain that can respond to a ligand. In some embodiments, the sensor domain is an RNA aptamer that modulates processing of the miRNA by an RNA processing enzyme, for example, Drosha.
    Type: Grant
    Filed: April 2, 2010
    Date of Patent: September 29, 2015
    Assignee: California Institute of Technology
    Inventors: Christina D. Smolke, Chase L. Beisel
  • Modular polynucleotides for ligand-controlled regulatory systems
    Patent number: 8367815
    Abstract: The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing.
    Type: Grant
    Filed: September 18, 2008
    Date of Patent: February 5, 2013
    Assignee: California Institute of Technology
    Inventors: Christina D. Smolke, Maung Nyan Win, Chase L. Beisel
  • INTEGRATED - LIGAND-RESPONSIVE MICRORNAS
    Publication number: 20100255545
    Abstract: The present application relates to nucleic acids that encode an miRNA and a sensor domain that can respond to a ligand. In some embodiments, the sensor domain is an RNA aptamer that modulates processing of the miRNA by an RNA processing enzyme, for example, Drosha.
    Type: Application
    Filed: April 2, 2010
    Publication date: October 7, 2010
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Christina D. Smolke, Chase L. Beisel
  • General composition framework for ligand-controlled regulatory systems
    Publication number: 20090143327
    Abstract: The invention provides an improved design for the construction of extensible nucleic acid-based, ligand-controlled regulatory systems, and the nucleic acid regulatory systems resulting therefrom. The invention contemplates improving the design of the switches (ligand-controlled regulatory systems) through the design of an information transmission domain (ITD). The improved ITD eliminates free-floating ends of the switching and the competing strands, and localizes competitive hybridization events to a contiguous strand of competing and switching strands in a strand-displacement mechanism-based switch, thereby improving the kinetics of strand-displacement. The improved regulatory systems have many uses in various biological systems, including gene expression control or ligand-concentration sensing.
    Type: Application
    Filed: September 18, 2008
    Publication date: June 4, 2009
    Inventors: Christina D. Smolke, Maung Nyan Win, Chase L. Beisel