Abstract: The disclosure relates to modulating pyruvate kinase and provides novel chemical compounds useful as activators of PKR, as well as various uses of these compounds. PKR activating compounds are useful in the treatment of diseases and disorders associated with PKR and/or PKM2, such as pyruvate kinase deficiency (PKD), sickle cell disease (SCD), and thalassemia.

Abstract: Systems and methods for time-resolved spectroscopy. Exemplary methods include: providing first, second, and third light using an excitation source; receiving first scattered light from a material responsive to the providing the first light; signaling the detector, after a delay, to provide a first spectrum of the received first scattered light; receiving second scattered light from the material responsive to the providing the second light; signaling the detector, after the delay, to provide a second spectrum of the received second scattered light; receiving third scattered light from the material responsive to the providing the third light; signaling the detector, after the delay, to provide a third spectrum of the received third scattered light; recovering a spectrum of the material using the first spectrum, second spectrum, and third spectrum; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.

Abstract: A system, method, and computer program product for presenting a video. A method of the present invention includes a link-map, where the link-map comprises one or more segments and one or more links between segments and where each link is associated with a user category. The method further includes retrieving a current segment to play for a user associated with a user category. The retrieving includes traversing a link of the link-map based on the user category. The retrieving further includes selecting the current segment to play from the plurality of segments based on traversing the link-map. The method further includes playing the current segment. The method further includes repeating the retrieving and playing steps until an end condition is reached.

Abstract: A system, method, and computer program product for presenting a video. A method of the present invention includes a link-map, where the link-map comprises one or more segments and one or more links between segments and where each link is associated with a user category. The method further includes retrieving a current segment to play for a user associated with a user category. The retrieving includes traversing a link of the link-map based on the user category. The retrieving further includes selecting the current segment to play from the plurality of segments based on traversing the link-map. The method further includes playing the current segment. The method further includes repeating the retrieving and playing steps until an end condition is reached.

Abstract: Systems and methods for time-resolved spectroscopy. Exemplary methods include: providing first, second, and third light using an excitation source; receiving first scattered light from a material responsive to the providing the first light; signaling the detector, after a delay, to provide a first spectrum of the received first scattered light; receiving second scattered light from the material responsive to the providing the second light; signaling the detector, after the delay, to provide a second spectrum of the received second scattered light; receiving third scattered light from the material responsive to the providing the third light; signaling the detector, after the delay, to provide a third spectrum of the received third scattered light; recovering a spectrum of the material using the first spectrum, second spectrum, and third spectrum; and identifying at least one molecule of the material using the recovered spectrum and a database of identified spectra.

Abstract: A system, method, and computer program product for presenting a video. A method of the present invention includes a link-map, where the link-map comprises one or more segments and one or more links between segments and where each link is associated with a user category. The method further includes retrieving a current segment to play for a user associated with a user category. The retrieving includes traversing a link of the link-map based on the user category. The retrieving further includes selecting the current segment to play from the plurality of segments based on traversing the link-map. The method further includes playing the current segment. The method further includes repeating the retrieving and playing steps until an end condition is reached.

Abstract: An optical amplifier system for amplifying an input wavelength division multiplexed (WDM) optical signal with a first optical coupler to extract a portion of the power of the input signal, an erbium-doped fiber amplifier to generate an output signal and a second optical coupler to extract a portion of the power of the output signal. A spectral monitoring unit having a volume phase grating separates the extracted input and output signals into spectral components. A photo-detector array of the spectral monitoring unit determines the power level of the spectral components. The system further includes a controller operative to control the operation of the amplifier in response to the power levels of the spectral components.