Patents by Inventor Chatarina Larsson

Chatarina Larsson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for identifying nucleic acid sequences
    Patent number: 9556473
    Abstract: Embodiments relate to the detection of RNA in a sample of cells. More particularly, methods concern the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ. In additional methods, rolling circle amplification products are sequenced.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: January 31, 2017
    Assignee: LEICA BIOSYSTEMS NEWCASTLE LTD
    Inventors: Mats Nilsson Bernitz, Chatarina Larsson, Ida Grundberg
  • METHODS FOR IDENTIFYING NUCLEIC ACID SEQUENCES
    Publication number: 20140120534
    Abstract: Embodiments relate to the detection of RNA in a sample of cells. More particularly, methods concern the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ. In additional methods, rolling circle amplification products are sequenced.
    Type: Application
    Filed: August 22, 2013
    Publication date: May 1, 2014
    Inventors: MATS NILSSON BERNITZ, Chatarina LARSSON, Ida GRUNDBERG
  • Methods for localized in situ detection of mRNA
    Patent number: 8551708
    Abstract: The present invention relates to the detection of RNA in a sample of cells. More particularly, the present invention relates to the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ.
    Type: Grant
    Filed: February 15, 2012
    Date of Patent: October 8, 2013
    Assignee: Leica Biosystems Newcastle Ltd.
    Inventors: Mats Nilsson Bernitz, Chatarina Larsson, Ida Grundberg
  • Methods for localized in situ detection of mRNA
    Patent number: 8551710
    Abstract: The present invention relates to the detection of RNA in a sample of cells. More particularly, the present invention relates to the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ.
    Type: Grant
    Filed: July 5, 2012
    Date of Patent: October 8, 2013
    Assignee: Leica Biosystems Newcastle Ltd.
    Inventors: Mats Nilsson Bernitz, Chatarina Larsson, Ida Grundberg
  • METHODS FOR LOCALIZED IN SITU DETECTION OF mRNA
    Publication number: 20130004953
    Abstract: The present invention relates to the detection of RNA in a sample of cells. More particularly, the present invention relates to the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ.
    Type: Application
    Filed: July 5, 2012
    Publication date: January 3, 2013
    Inventors: Mats Nilsson Bernitz, Chatarina Larsson, Ida Gundberg
  • METHODS FOR LOCALIZED IN SITU DETECTION OF mRNA
    Publication number: 20120270214
    Abstract: The present invention relates to the detection of RNA in a sample of cells. More particularly, the present invention relates to the localized detection of RNA in situ. The method relies on the conversion of RNA to complementary DNA prior to the targeting of the cDNA with a padlock probe(s). The hybridization of the padlock probe(s) relies on the nucleotide sequence of the cDNA which is derived from the corresponding nucleotide sequence of the target RNA. Rolling circle amplification of the subsequently circularized padlock probe produces a rolling circle product which may be detected. Advantageously, this allows the RNA to be detected in situ.
    Type: Application
    Filed: February 15, 2012
    Publication date: October 25, 2012
    Inventors: MATS NILSSON BERNITZ, Chatarina Larsson, Ida Grundberg