Patents by Inventor Chau-Ching Liu

Chau-Ching Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and systems using C4 gene copy number and cell-bound complement activation products for identification of lupus and pre-lupus
    Patent number: 12130288
    Abstract: Cell-bound complement activation product (CB-CAP) profiling is combined with determination of C4 gene copy number as biomarkers for lupus and/or pre-lupus diagnosis and monitoring.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: October 29, 2024
    Assignees: Allegheny Singer Research Institute, Research Institute At Nationwide Children's Hospital
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi, C. Yung Yu
  • Methods for Determining a Level of Cell-Bound Complement Activation Product
    Publication number: 20230375544
    Abstract: This disclosure provides a novel method for detecting one or more cell fragment-bound complement activation products (CFB-CAPs) using a capillary flow system. The method eliminates the need for fresh, live cellular samples and detection by flow cytometric methods. The method as disclosed has a wide variety of applications, including diagnosing or monitoring lupus or pre-lupus and other diseases or disorders (e.g., autoimmune or inflammatory diseases or disorders).
    Type: Application
    Filed: September 28, 2021
    Publication date: November 23, 2023
    Inventors: Joseph M. Ahearn, Chau-Ching Liu
  • METHODS AND DEVICES FOR DETERMINING A LEVEL OF A COMPLEMENT ACTIVATION PRODUCT
    Publication number: 20230094382
    Abstract: This disclosure provides a novel method for detecting one or more cell-bound complement activation products (CB-CAPs) using a capillary tube agglutination/lattice formation test. The method as disclosed has a wide variety of applications, including diagnosing or monitoring lupus or pre-lupus and other diseases or disorders (e.g., autoimmune or inflammatory diseases or disorders).
    Type: Application
    Filed: September 27, 2022
    Publication date: March 30, 2023
    Inventors: Joseph M. Ahearn, Chau-Ching Liu
  • METHODS AND SYSTEMS USING C4 GENE COPY NUMBER AND CELL-BOUND COMPLEMENT ACTIVATION PRODUCTS FOR IDENTIFICATION OF LUPUS AND PRE-LUPUS
    Publication number: 20190302112
    Abstract: Cell-bound complement activation product (CB-CAP) profiling is combined with determination of C4 gene copy number as biomarkers for lupus and/or pre-lupus diagnosis and monitoring.
    Type: Application
    Filed: May 24, 2017
    Publication date: October 3, 2019
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi, C. Yung Yu
  • Cell-bound complement activation product assays as companion diagnostics for antibody-based drugs
    Patent number: 10067128
    Abstract: Methods, systems, and kits useful for determining whether a subject is likely to benefit from therapy with an antibody are provided. In particular aspects, cell-bound complement activation products (CB-CAPs) associated with B lymphocytes may serve as diagnostic biomarkers.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: September 4, 2018
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • Cell-bound complement activation products as diagnostic biomarkers for pre-lupus
    Patent number: 9863946
    Abstract: Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus. This document also describes methods for determining whether a patient who has been determined to exhibit pre-Lupus has progressed to exhibiting definite Lupus.
    Type: Grant
    Filed: September 13, 2016
    Date of Patent: January 9, 2018
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • Anti-lymphocyte autoantibodies as diagnostic biomarkers
    Patent number: 9709564
    Abstract: Provided are methods, systems, and kits for diagnosing or monitoring systemic lupus erythematosus in an individual. In particular aspects, in a blood sample containing white blood cells from the individual, autoantibodies deposited on or contacting with the surface of a T lymphocyte in the sample are quantitated.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: July 18, 2017
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • CELL-BOUND COMPLEMENT ACTIVATION PRODUCTS AS DIAGNOSTIC BIOMARKERS FOR PRE-LUPUS
    Publication number: 20170067893
    Abstract: Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus. This document also describes methods for determining whether a patient who has been determined to exhibit pre-Lupus has progressed to exhibiting definite Lupus.
    Type: Application
    Filed: September 13, 2016
    Publication date: March 9, 2017
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • CELL-BOUND COMPLEMENT ACTIVATION PRODUCT ASSAYS AS COMPANION DIAGNOSTICS FOR ANTIBODY-BASED DRUGS
    Publication number: 20170030905
    Abstract: Methods, systems, and kits useful for determining whether a subject is likely to benefit from therapy with an antibody are provided. In particular aspects, cell-bound complement activation products (CB-CAPs) associated with B lymphocytes may serve as diagnostic biomarkers.
    Type: Application
    Filed: July 29, 2016
    Publication date: February 2, 2017
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • Cell-bound complement activation products as diagnostic biomarkers for pre-lupus
    Patent number: 9495517
    Abstract: Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus.
    Type: Grant
    Filed: August 6, 2015
    Date of Patent: November 15, 2016
    Assignee: Allegheny-Singer Research Institute
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • ANTI-LYMPHOCYTE AUTOANTIBODIES AS DIAGNOSTIC BIOMARKERS
    Publication number: 20160041164
    Abstract: Provided are methods, systems, and kits for diagnosing or monitoring systemic lupus erythematosus in an individual. In particular aspects, in a blood sample containing white blood cells from the individual, autoantibodies deposited on or contacting with the surface of a T lymphocyte in the sample are quantitated.
    Type: Application
    Filed: August 7, 2015
    Publication date: February 11, 2016
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • CELL-BOUND COMPLEMENT ACTIVATION PRODUCTS AS DIAGNOSTIC BIOMARKERS FOR PRE-LUPUS
    Publication number: 20150339449
    Abstract: Cell-bound complement activation product (CB-CAP) profiling and scoring serve as diagnostic biomarkers for patients to determine whether a patient who has not met at least four American College of Rheumatology (or similar e.g. SLICC) criteria for a definite Lupus diagnosis should be classified as exhibiting a pre-existing condition that this document refers to as pre-Lupus.
    Type: Application
    Filed: August 6, 2015
    Publication date: November 26, 2015
    Inventors: Joseph M. Ahearn, Chau-Ching Liu, Susan M. Manzi
  • DIAGNOSING AND MONITORING INFLAMMATORY DISEASES BY MEASURING COMPLEMENT COMPONENTS ON WHITE BLOOD CELLS
    Publication number: 20110275060
    Abstract: The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
    Type: Application
    Filed: July 19, 2011
    Publication date: November 10, 2011
    Applicant: University of Pittsburgh - Of the Commonwealth System of Higher Education
    Inventors: Joseph M. Ahearn, Susan M. Manzi, Chau-Ching Liu
  • DIAGNOSING AND MONITORING INFLAMMATORY DISEASES BY MEASURING COMPLEMENT COMPONENTS ON WHITE BLOOD CELLS
    Publication number: 20090298198
    Abstract: The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
    Type: Application
    Filed: July 29, 2009
    Publication date: December 3, 2009
    Applicant: University of Pittsburgh
    Inventors: Joseph M. Ahearn, Susan M. Manzi, Chau-Ching Liu
  • Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
    Patent number: 7585640
    Abstract: The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
    Type: Grant
    Filed: May 11, 2005
    Date of Patent: September 8, 2009
    Assignee: University of Pittsburgh
    Inventors: Joseph M. Ahearn, Susan M. Manzi, Chau-Ching Liu
  • Diagnosing and monitoring inflammatory diseases by measuring complement components on white blood cells
    Publication number: 20070026387
    Abstract: The invention is related to methods of diagnosing inflammatory diseases or conditions by determining levels of components of the complement pathway on the surface of white blood cells.
    Type: Application
    Filed: May 11, 2005
    Publication date: February 1, 2007
    Inventors: Joseph Ahearn, Susan Manzi, Chau-Ching Liu