Abstract: A method of predicting the responsiveness of a subject with cancer to treatment with a modulator of the HER signalling pathway, wherein the method comprises detecting the level of expression of EGR4-S in a sample of the subject, wherein the subject is likely to be responsive to treatment with the modulator of the HER signalling pathway if EGR4-S expression is at or above a predetermined level in the sample of the subject, and wherein the subject is likely to be resistant to treatment with the modulator of the HER signalling pathway if EGR4-S expression is at or below a predetermined level in the sample of the subject.

Abstract: A system for forming a seal between wellbore components includes an annular seal having a first leg and a second leg, the first leg positioned proximate a first wellbore component and the second leg positioned proximate a second wellbore component, wherein upon activation of the seal, the first leg engages the first wellbore component and the second leg engages the second wellbore component. The system also includes an energizing ring adapted to activate the seal, the energizing ring extending into an opening of the seal to drive the first leg and the second leg radially outward relative to an axis of the seal. The energizing ring includes bumps positioned to align with respective grooves formed on both the first leg and the second leg, upon activation of the seal, the bumps transmitting an uphole force into components having an axial component and a radial component.

Abstract: A pen format liquid collection device includes an elongate generally tubular housing (12, 112, 212, 312) able to be held by hand and having an opening at one end, and at least one liquid take-up element (30, 130, 230, 330) mounted in the housing so as to be positioned or positionable to project at the opening, the at least one liquid take-up element then further postionable by hand manipulation of the housing to contact a volume of liquid to thereby take-up a sample of the liquid to be analysed. At least one retention element (230a, 330a) is supported in the housing. The at least one liquid take-up element and the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.

Abstract: A pen format liquid collection device includes an elongate generally tubular housing (12, 112, 212, 312) able to be held by hand and having an opening at one end, and at least one liquid take-up element (30, 130, 230, 330) mounted in the housing so as to be positioned or positionable to project at the opening, the at least one liquid take-up element then further postionable by hand manipulation of the housing to contact a volume of liquid to thereby take-up a sample of the liquid to be analysed. At least one retention element (230a, 330a) is supported in the housing. The at least one liquid take-up element and the at least one retention element are arranged whereby they are relatively movable into contact, and the at least one retention element is adapted on contact to in turn take-up the sample and retain the sample or a component thereof for in situ analysis or later recovery while protected within the housing. The liquid take-up element is preferably a capillary.

Abstract: A system for forming a seal between wellbore components includes an annular seal having a first leg and a second leg, the first leg positioned proximate a first wellbore component and the second leg positioned proximate a second wellbore component, wherein upon activation of the seal, the first leg engages the first wellbore component and the second leg engages the second wellbore component. The system also includes an energizing ring adapted to activate the seal, the energizing ring extending into an opening of the seal to drive the first leg and the second leg radially outward relative to an axis of the seal. The energizing ring includes bumps positioned to align with respective grooves formed on both the first leg and the second leg, upon activation of the seal, the bumps transmitting an uphole force into components having an axial component and a radial component.

Abstract: A key assembly is press fit into an annular space between a box and pin member to resist relative rotation of the box and pin members. The key assembly includes wedge like members that contact one another along complementary tapered surfaces, and when in contact generate radial forces into the box and pin member to secure the connection between the box and pin. The outer wedge is inserted first into the annular space between the box and pin members, and has rows of elongate teeth that project radially outward into contact with an inner surface of the box member. Because the outer wedge is pushed radially outward against the box member rather than axially sliding therebetween, the teeth protrude into the surface of the box member thereby increasing the anti-rotation force created by the outer wedge.

Abstract: A seal assembly for use with a casing hanger that includes a pair of split rings held together by a threaded fastener. Torqueing the fastener axially compresses one of the rings so that it expands radially inward into sealing engagement with a wall of wellbore casing, and radially outward against an inner wall of a wellhead housing. Support grommets are provided where the fastener enters and exits the compressible ring. Protrusions on a side of the support grommets project into the compressible ring and create a sealing interface between each support grommet and compressible ring. O-rings line inner circumferences of the support grommets to seal between the support grommets and fasteners. A threaded end on a lower end of the fastener has a diameter less than an inner diameter of the O-rings to prevent damaging the O-rings during assembly.

Abstract: A key assembly is press fit into an annular space between a box and pin member to resist relative rotation of the box and pin members. The key assembly includes wedge like members that contact one another along complementary tapered surfaces, and when in contact generate radial forces into the box and pin member to secure the connection between the box and pin. The outer wedge is inserted first into the annular space between the box and pin members, and has rows of elongate teeth that project radially outward into contact with an inner surface of the box member. Because the outer wedge is pushed radially outward against the box member rather than axially sliding therebetween, the teeth protrude into the surface of the box member thereby increasing the anti-rotation force created by the outer wedge.

Abstract: A gate valve assembly having a body, a gate, a stem, and a backseat for sealing between the stem and the body. The backseat is an annular member with a complementary surface on its inside that fits over a spherically shaped section of the stem; thus allowing the backseat to rotate and pivot with respect to the stem. An outer surface of the backseat is beveled for sealingly engaging a stem passage formed through the body. A flex member is provided that is for sealing a surface adjacent the backseat. The flex member can form a seal between the backseat member and the stem or between an annular retainer and the backseat.

Abstract: A seal assembly for use with a casing hanger that includes a pair of split rings held together by a threaded fastener. Torqueing the fastener axially compresses one of the rings so that it expands radially inward into sealing engagement with a wall of wellbore casing, and radially outward against an inner wall of a wellhead housing. Support grommets are provided where the fastener enters and exits the compressible ring. Protrusions on a side of the support grommets project into the compressible ring and create a sealing interface between each support grommet and compressible ring. O-rings line inner circumferences of the support grommets to seal between the support grommets and fasteners. A threaded end on a lower end of the fastener has a diameter less than an inner diameter of the O-rings to prevent damaging the O-rings during assembly.

Abstract: An actuator for a gate valve having a gate has a stem coupled to a gate. A spring is coupled to the stem and has an extended length position while the gate is in a closed position and a contracted length position while the gate is in an open position. The spring has a degressive characteristic such that a graph of a force required to move the gate from the closed position to the open position versus a deflection of the spring is a nonlinear curve with a positive slope that decreases when moving from the closed to the open position. The spring may be an array of wavy springs arranged in nested and in valley-to-crest combinations.

Abstract: An apparatus for applying movement to the joints of a human patient is provided. The apparatus includes an exoskeleton assembly with segments that can be secured to the patient. One or more motor modules are removably coupled to a supporting structure of the exoskeleton assembly, and each motor module includes multiple motor drives. A plurality of actuating members is operatively connected to each motor module. A first end of each actuating member is connected to one of the motor drives and a second end of each actuating member is coupled to a segment of the exoskeleton assembly. Each actuating member can be driven by a respective motor drive to impart movement in multiple degrees of freedom to individual joints.

Abstract: A wellhead assembly having an inner tubular insertable into an outer tubular. A packoff is provided on an outer surface of the inner tubular for sealing between the inner and outer tubulars. The packoff includes an energizing ring, a U-shaped seal member, and a nut for retaining the seal member against the energizing ring. The seal member includes legs that are spaced apart by interaction with the energizing ring. The outer tubular has a bore wall that is profiled so that when the inner tubular is inserted into the outer tubular, an outer leg of the seal member is spaced radially outward from the bore wall until the inner tubular is landed in the outer tubular. When the inner tubular member is landed, a portion of the bore wall adjacent the outer leg tapers radially inward into sealing contact with the outer leg of the seal member.

Abstract: A gate valve assembly having a body, a gate, a stem, and a backseat for sealing between the stem and the body. The backseat is an annular member with a complementary surface on its inside that fits over a spherically shaped section of the stem; thus allowing the backseat to rotate and pivot with respect to the stem. An outer surface of the backseat is beveled for sealingly engaging a stem passage formed through the body. A flex member is provided that is for sealing a surface adjacent the backseat. The flex member can form a seal between the backseat member and the stem or between an annular retainer and the backseat.

Abstract: An apparatus for manipulating joints of a limb of a patient is provided. The limb comprises a plurality of limb segments, Each limb segment connects one or more joints. The apparatus includes one or more motor modules removably coupled to a supporting structure configured on the limb, each motor module including a plurality of motor drives. The apparatus also includes a manipulating exoskeleton assembly comprising a plurality of exoskeleton segments removably secured on a limb segment. Further, a plurality of actuating members is operatively connected to each motor module of the one or more motor modules. A first end of each actuating member is operatively connected to a motor drive of a motor module and a second end is removably coupled to an exoskeleton segment of the plurality of exoskeleton segments. Each actuating member is driven by a motor drive operatively connected to the each actuating member.

Abstract: A gate valve has downstream shear and seal capabilities in which the gate will stroke far enough to cover the downstream seat interface, and has a single shearing surface for shearing of a wireline. The gate has an inlay of a hard ductile material such as Stellite® along the shearing edge of the gate. The gate also has a coating of an extremely hard material such as tungsten carbide on the sealing surface of the gate. The seat also has an inlay of a hard ductile material such as Stellite® along its shearing edge. The gate fully covers and seals the upstream seat interface after the shear media has fallen below the upstream gate/seat interface. An upstream lip seal for the upstream seat ring is energized to seal on upstream pressure.