Patents by Inventor Chaul-Min Pai
Chaul-Min Pai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210244757Abstract: The present invention relates to a pharmaceutical composition for treating cancer. More specifically, it relates to a pharmaceutical composition for treating cancer: which comprises an ionic compound in which two compounds selected from ascorbic acid, dichloroacetic acid and lactate are combined with one metal ion; has better therapeutic effect by overlapping and complex disturbances of cancer cell metabolism because different compounds are simultaneously uptake into cancer cells and each acts through different mechanisms on cancer cells, compared to the conventional anticancer drugs focusing on one specific mutation or cancer cell growth signal; and can more effectively inhibit the proliferation, invasion and metastasis of cancer cells because it is less susceptible to drug.Type: ApplicationFiled: August 19, 2019Publication date: August 12, 2021Inventor: Chaul Min Pai
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Patent number: 9511026Abstract: A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.Type: GrantFiled: February 27, 2014Date of Patent: December 6, 2016Assignee: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Kyung-Hee Kim, Hyun-Ki Lee, Jun-Seok Hwang, Su-Jong Hwang, Chaul-Min Pai
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Publication number: 20150086623Abstract: A controlled-release pharmaceutical composition including first and second groups of microparticles, each of the microparticles including a core including tamsulosin or pharmaceutically acceptable salts thereof, a controlled-release polymer coating layer formed on the core, and an enteric polymer outer layer formed on the controlled-release polymer coating layer, wherein the average thickness of the controlled-release polymer coating layer is different in each of the first and second groups of microparticles, and an oral formulation including the same, are provided. This pharmaceutical composition can easily control the extent of release of an active ingredient depending on changes in pH in the intestinal tract and the release pattern of the active ingredient in the small intestine, thus preventing the active ingredient from being rapidly transferred into the blood to thereby minimize side-effects, and maintaining the effective blood concentration of the active ingredient for a predetermined period of time.Type: ApplicationFiled: December 1, 2014Publication date: March 26, 2015Inventors: Ho-Jin Chung, Sang-Yeob Park, Chaul-Min Pai
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Publication number: 20140175686Abstract: A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.Type: ApplicationFiled: February 27, 2014Publication date: June 26, 2014Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Kyung-Hee KIM, Hyun-Ki Lee, Jun-Seok Hwang, Su-Jong Hwang, Chaul-Min Pai
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Patent number: 8465768Abstract: Disclosed is a pharmaceutical composition for release control comprising a plurality of particles for release control. The plurality of particles for release control comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material. The plurality of particles for release control are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The particle groups are identical in terms of the composition of the polymer in the polymer coating layer, but are different in terms of the average thickness of the coated layer. The pharmaceutical composition for release control according to the present invention may control the release pattern of methylphenidate contained in the core material as desired, and can be used as an oral formulation in a variety of forms such as orally disintegrating tablets, etc.Type: GrantFiled: November 6, 2009Date of Patent: June 18, 2013Assignee: Samyang Biopharmaceuticals CorporationInventors: Sang Yeob Park, Hojin Chung, Chaul Min Pai
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Publication number: 20130052264Abstract: A controlled-release pharmaceutical composition including first and second groups of microparticles, each of the microparticles including a core including tamsulosin or pharmaceutically acceptable salts thereof, a controlled-release polymer coating layer formed on the core, and an enteric polymer outer layer formed on the controlled-release polymer coating layer, wherein the average thickness of the controlled-release polymer coating layer is different in each of the first and second groups of microparticles, and an oral formulation including the same, are provided. This pharmaceutical composition can easily control the extent of release of an active ingredient depending on changes in pH in the intestinal tract and the release pattern of the active ingredient in the small intestine, thus preventing the active ingredient from being rapidly transferred into the blood to thereby minimize side-effects, and maintaining the effective blood concentration of the active ingredient for a predetermined period of time.Type: ApplicationFiled: April 27, 2011Publication date: February 28, 2013Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Ho-Jin Chung, Sang-Yeob Park, Chaul-Min Pai
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Publication number: 20120076838Abstract: A poorly soluble drug containing microsphere with improved bioavailability, an oral formulation comprising the same, and a method of preparing the same are provided, wherein the poorly soluble drug containing microsphere is a solid dispersion wherein the poorly soluble drug is dispersed in the water-soluble polymer carrier in a noncrystalline form by spray drying, thus increasing bioavailability of the poorly soluble drug.Type: ApplicationFiled: May 27, 2010Publication date: March 29, 2012Applicant: SAMYANG BIOPHARMACEUTICALS CORPORATIONInventors: Kyung-Hee Kim, Hyun-Ki Lee, Jun- Seok Hwang, Su-long Hwang, Chaul-Min Pai
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Publication number: 20110223247Abstract: Disclosed is a pharmaceutical composition for release control comprising a plurality of particles for release control. The plurality of particles for release control comprise a core material containing methylphenidate and a polymer coating layer for release control formed on the core material. The plurality of particles for release control are divided into two or more groups based on the average thickness of the polymer coating layer for release control. The particle groups are identical in terms of the composition of the polymer in the polymer coating layer, but are different in terms of the average thickness of the coated layer. The pharmaceutical composition for release control according to the present invention may control the release pattern of methylphenidate contained in the core material as desired, and can be used as an oral formulation in a variety of forms such as orally disintegrating tablets, etc.Type: ApplicationFiled: November 6, 2009Publication date: September 15, 2011Applicant: SAMYANG CORPORATIONInventors: Sang Yeob Park, Hojin Chung, Chaul Min Pai
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Patent number: 7749533Abstract: A fast-melting pharmaceutical tablet comprises a porous, plastic substance, a water penetration enhancer and a binder. One or more drugs can be incorporated into the formulation at different stages of the process so as to afford a pharmaceutically active tablet. Methods of making the pharmaceutical tablet entail combining the porous, plastic material, the water penetration enhancing agent, and the binder so as to form highly plastic granules, which are compressed into tablets. The resulting tablets dissolve rapidly in the mouth and have good hardness with low brittleness. The tablets are particularly valuable to those who have difficulty swallowing conventional pills.Type: GrantFiled: May 7, 2004Date of Patent: July 6, 2010Assignee: Akina, Inc.Inventors: Yourong Fu, Chaul Min Pai, Sang Yeob Park, Gun Seomoon, Kinam Park
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Patent number: 7674767Abstract: The present invention relates to an orally administrable composition containing nanoparticles with the particle size of 500 nm or less, comprising 0.1-30 weight % of a complex of a water-soluble drug and a counter-ion substance in which the charged water-soluble drug is bonded with the counter-ion substance, 0.5-80 weight % of a lipid, 0.5-80 weight % of a polymer, and 1-80 weight % of an emulsifier, wherein the weight ratio of said lipid and said polymer is in the range of 1:0.05-3, and a preparation method thereof. The composition of the present invention has high gastrointestinal absorption rate upon oral administration, and has high drug entrapping rate in the nanoparticle, and is also stable against lipases.Type: GrantFiled: December 24, 2004Date of Patent: March 9, 2010Assignee: Samyang CorporationInventors: Chaul Min Pai, Mi Hong Min, Jun Seok Hwang, Kyung Mi Cho
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Patent number: 7273619Abstract: The present invention relates to a transdermal composition of an antivomiting agent, and more particularly to a transdermal composition of an antivomiting agent which can minimize skin irritation by employing tropisetron as the antivomiting agent as well as by adjusting its pH to be in the range of 8 to 9 thus enhancing its rate of skin penetration thereby reducing the amount of a skin penetration enhancer used.Type: GrantFiled: April 15, 2003Date of Patent: September 25, 2007Assignee: Samyang CorporationInventors: Chaul Min Pai, Jin Deog Song, Joong Woong Cho
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Publication number: 20070154559Abstract: The present invention relates to an orally administrable composition containing nanoparticles with the particle size of 500 nm or less, comprising 0.1˜30 weight % of a complex of a water-soluble drug and a counter-ion substance in which the charged water-soluble drug is bonded with the counter-ion substance, 0.5˜80 weight % of a lipid, 0.5˜80 weight % of a polymer, and 1˜80 weight % of an emulsifier, wherein the weight ratio of said lipid and said polymer is in the range of 1:0.05˜3, and a preparation method thereof. The composition of the present invention has high gastrointestinal absorption rate upon oral administration, and has high drug entrapping rate in the nanoparticle, and is also stable against lipases.Type: ApplicationFiled: December 24, 2004Publication date: July 5, 2007Inventors: Chaul-Min Pai, Mi Hong Min, Jun Hwang, Kyung Mi Cho
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Patent number: 7070610Abstract: The present invention relates to a monofilament suture prepared by co-extruding polymers having different Young's moduli and to a process for preparing the same. The suture is prepared in such a form that a polymer having a high Young's modulus surrounds a polymer having a low Young's modulus. The monofilament suture prepared by the present invention has excellent knot security, flexibility and/or knot strength.Type: GrantFiled: August 13, 2002Date of Patent: July 4, 2006Assignee: Samyang CorporationInventors: Jung-nam Im, Jang-il Seo, Chong-taek Hong, Hye-sung Yoon, Chaul-min Pai
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Publication number: 20040098049Abstract: The present invention relates to a monofilament suture prepared by co-extruding polymers having different Young's moduli and to a process for preparing the same. The suture is prepared in such a form that a polymer having a high Young's modulus surrounds a polymer having a low Young's modulus. The monofilament suture prepared by the present invention has excellent knot security, flexibility and/or knot strength.Type: ApplicationFiled: September 29, 2003Publication date: May 20, 2004Inventors: Jung-Nam Im, Jang-Il Seo, Chong-Taek Hong, Chaul-Min Pai, Hye-Sung Yoon
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Publication number: 20040022835Abstract: The present invention relates to a transdermal composition of an antivomiting agent, and more particularly to a transdermal composition of an antivomiting agent which can minimize skin irritation by employing tropisetron as the antivomiting agent as well as by adjusting its pH to be in the range of 8 to 9 thus enhancing its rate of skin penetration thereby reducing the amount of a skin penetration enhancer used.Type: ApplicationFiled: April 15, 2003Publication date: February 5, 2004Applicant: SAMYANG CORPORATIONInventors: Chaul Min Pai, Jin Deog Song, Joong Woong Cho
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Publication number: 20030236319Abstract: The present invention relates to AB or ABA type block copolymers comprising p-dioxanone A blocks, and segmented copolymer B blocks comprising &egr;-caprolactone and trimethylene carbonate. The block copolymers are well suited for use as general medical and surgical articles requiring high flexibility, excellent knot-security and rapid absorption.Type: ApplicationFiled: November 27, 2002Publication date: December 25, 2003Inventors: Hye-sung Yoon, Tae-Hun Kim, Myoung-Seok Koh, Chong-taek Hong, Chaul-min Pai, Jung-nam Im, Jang-il Seo
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Publication number: 20030187476Abstract: The present invention relates to a monofilament suture prepared by co-extruding polymers having different Young's moduli and to a process for preparing the same. The suture is prepared in such a form that a polymer having a high Young's modulus surrounds a polymer having a low Young's modulus. The monofilament suture prepared by the present invention has excellent knot security, flexibility and/or knot strength.Type: ApplicationFiled: August 13, 2002Publication date: October 2, 2003Inventors: Jung-Nam Im, Jang-Il Seo, Chong-Taek Hong, Hye-Sung Yoon, Chaul-Min Pai
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Patent number: 6413494Abstract: A colonic drug delivery composition contains a first polysaccharide and a second polysaccharide wherein both polysaccharide are degradable by colonic enzymes and are mixed at a environmental pH of about 7 or above, without use of a cross-linking agent. A colon selective pharmaceutical composition and dosage form for oral delivery of a drug, diagnostic reagent, or mixture thereof includes the drug, diagnostic reagent, or mixture thereof in contact with the polysaccharide composition. A method of preparing such a colonic drug delivery composition and the colon selective pharmaceutical composition and dosage from are also disclosed.Type: GrantFiled: May 25, 1999Date of Patent: July 2, 2002Assignee: Samyang CorporationInventors: Seung Seo Lee, Chang Baeg Lim, Chaul Min Pai, Sujung Lee, In Park, Moon Gun Seo, Heenam Park
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Patent number: 6322805Abstract: A biodegradable polymeric drug carrier micelle composition capable of solubilizing a hydrophobic drug in a hydrophilic environment comprises a biodegradable polymeric drug carrier micelle and a hydrophobic drug wherein the drug is physically trapped within and not covalently bonded to the polymeric drug carrier micelle. The drug carrying micelle is capable of dissolving in water to form a solution thereof, and the drug carrier comprises an amphiphilic block copolymer having a hydrophilic poly(alkylene oxide) component, and a biodegradable hydrophobic polymer component selected from the group consisting of poly(lactic acid), poly(glycoloc acid), poly(lactic-co-glycolic acid), poly(&egr;-caprolactone), a derivative thereof and a mixture thereof. Preferably the amphiphilic block copolymer has a molecular weight in a range of about 1430 to about 6000 Daltons and the hydrophilic component content is in a range of about 50 wt % to about 70 wt % based on the total weight of the block copolymer.Type: GrantFiled: April 12, 2000Date of Patent: November 27, 2001Assignee: Samyang CorporationInventors: Sung-Chul Kim, Eun-Ok Chang, In-Suk Song, Chaul-Min Pai
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Patent number: 6319518Abstract: A composition comprising gelatin and a polysaccharide which is degradable by a colonic enzyme and, optionally, with an aldehyde and/or a polyvalent metal ion and/or an additional polysaccharide, which is not degraded or disintegrated in the upper gastrointestinal tract, thereby rendering the active substance loaded therein to be selectively delivered to the colon and to be effectively released in the colon.Type: GrantFiled: August 29, 1997Date of Patent: November 20, 2001Assignee: Samyang CorporationInventors: Seung-Seo Lee, Sung-Bum La, Chang-Baeg Lim, Sujung Lee, Bo-Youn Seo, Chaul-Min Pai