Abstract: Provided is a controlled release formulation and a preparation process thereof. Also provided is a method for treating Attention-Deficit Disorder (ADD) or Attention-Deficit Hyperactivity Disorder (ADHD).

Abstract: The present invention provides a controlled release pharmaceutical composition which exhibits reduced food effect.

Abstract: The present invention provides a controlled release pharmaceutical composition which exhibits reduced food effect.

Abstract: The present invention provides a method of manufacturing tablets. An example of the method involves preparing a placebo blend containing only excipients. This placebo blend is compressed into tablets having concavities such as pinholes or indentations. Separately, a dispersion containing an active pharmaceutical ingredient, a drug, or a drug substance is prepared. A predetermined amount of this dispersion is placed into those concavities, and the tablets are dried. In this method, an active ingredient is handled in the form of a dispersion rather than as a solid. In addition, once the tablets are dried, the active ingredient is trapped inside the concavities and remains unexposed to external physical friction. As a result, human contact with powders or dust of active ingredient during the manufacturing and shipping processes may be minimized in a cost-effective manner. The present invention is also directed to the tablets prepared by this method.

Abstract: A capsule which is dividable into accurate individual dosage units by the user is comprised of first and second capsule units, each being cylindrical about a longitudinal axis along the major part of its length. The capsule units are detachably joined in such manner that the longitudinal axes of the two capsule units are approximately co-linear. The capsule units may be detachable joined by adhesive, banding, or locking mechanical means, and the capsule may be comprised of two or more units.

Abstract: A fluidized bed dryer/granulator (10) for coating pellets (P) used in the preparation of pharmaceutical materials, comprises a chamber (11) having a top wall (12) and a bowl (16) at the bottom thereof and an axial air inlet (19) for directing a flow of air axially therethrough, and at least one removable air inlet (20, 21) positioned in the chamber for directing a circumferential flow of air into the chamber to interact with the axial flow to produce an orbital or swirling motion, enhancing the rate of treatment of the material in the chamber.