Patents by Inventor Che Serguera

Che Serguera has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE CONJUGATES AND USE THEREOF TO PROMOTE CAS NUCLEASE IMMUNE TOLERANCE IN GENOME ENGINEERING GENE THERAPY
    Publication number: 20260144887
    Abstract: In the field of, the use of polypeptide conjugates, compositions and methods for promoting immune tolerance to the CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats-CRISPR associated protein) system, for genome engineering gene therapy. The polypeptide conjugates includes a first component, which is an antigen-presenting cell antibody, and a second component, which is a Cas protein.
    Type: Application
    Filed: August 31, 2023
    Publication date: May 28, 2026
    Applicant: ASFALIA BIOLOGICS
    Inventor: Che SERGUERA
  • Lentiviral Vectors Having a Mutated Integrase Protein and uses Thereof
    Publication number: 20160230190
    Abstract: The present invention relates to a lentiviral vector wherein the expressed integrase protein comprises at least one point mutation consisting of the substitution of the aspartic acid residue at position 167 by an amino acid selected from the group consisting of histidine, arginine and lysine.
    Type: Application
    Filed: September 17, 2014
    Publication date: August 11, 2016
    Inventors: Che Serguera, Francois Lachapelle, Noelle Dufour, Muhammad Qamar Saeed
  • BHLH PROTEINS AND THEIR USE AS DRUGS
    Publication number: 20130210739
    Abstract: The present invention relates to at least one protein belonging to the bHLH family and/or at least a nucleic acid molecule coding for the bHLH proteins as drug.
    Type: Application
    Filed: July 21, 2011
    Publication date: August 15, 2013
    Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6), UNIVERSITE MONTPELLIER 2 SCIENCES ET TECHNIQUES
    Inventors: Jean-Philippe Hugnot, Pierre-Olivier Guichet, Che Serguera, Jacques Mallet
  • Non-integrative and non-replicative lentivirus, preparation and uses thereof
    Patent number: 8119119
    Abstract: The invention concerns a non-integrative and non-replicative recombinant lentivirus as well as its uses, in particular for preparing a composition for transferring genes in vitro, ex vivo or in vivo. The invention is useful for transferring genes in any mammal organism, for example in liver, muscle, pancreas or central nervous system (including the ocular sphere) tissues or cells, and in particular for treating disorders or pathologies such as, for example, central nervous system, including the ocular sphere, disorders.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: February 21, 2012
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Jacques Mallet, Che Serguera, Stéphanie Philippe, Chamsy Sarkis
  • Methods of gene transfer to astrocytes with mokola virus pseudotyped lentivirus vectors
    Patent number: 7749973
    Abstract: The invention relates to a defective lentivirus which is pseudotyped with a lyssavirus envelope of the PV (rabies virus) or MOK type (Mokola virus), for example, and to the use thereof, especially in the preparation of a composition for in vivo transfer of genes in astrocytes and also for the treatment of disorders of the central nervous system.
    Type: Grant
    Filed: May 31, 2002
    Date of Patent: July 6, 2010
    Assignee: Centre National de la Recherche Scientifique
    Inventors: Chamsy Sarkis, Yi He, Che Serguera, Noelle Dufour, Jacques Mallet
  • Non-Integrative And Non-Replicative Lentivirus , Preparation And Uses Thereof
    Publication number: 20080089863
    Abstract: The invention concerns a non-integrative and non-replicative recombinant lentivirus as well as its uses, in particular for preparing a composition for transferring genes in vitro, ex vivo or in vivo. The invention is useful for transferring genes in any mammal organism, for example in liver, muscle, pancreas or central nervous system (including the ocular sphere) tissues or cells, and in particular for treating disorders or pathologies such as, for example, central nervous system, including the ocular sphere, disorders.
    Type: Application
    Filed: June 24, 2005
    Publication date: April 17, 2008
    Inventors: Jacques Mallet, Che Serguera, Stephanie Philippe
  • Pseudotyping vih-1 vectors with the aid of rhabdovirus envelopes
    Publication number: 20040120929
    Abstract: The invention relates to a defective lentivirus which is pseudotyped with a lyssavirus envelope of the PV (rabies virus) or MOK type (Mokola virus), for example, and to the use thereof, especially in the preparation of a composition for in vivo transfer of genes in astrocytes and also for the treatment of disorders of the central nervous system.
    Type: Application
    Filed: February 12, 2004
    Publication date: June 24, 2004
    Inventors: Chamsy Sarkis, Yi He, Che Serguera, Noelle Dufour, Jacques Mallet