Abstract: The invention relates to a highly aligned and closely packed electrospun fiber assembly, wherein the fibers have at least an extension part or pore on the surface thereof. The invention also relates to a microtube array membrane (MTAM), comprising fiber assembly of the present disclosure. The invention also relates to the applications of these electrospun fiber assemblies in biological applications, and method of manufacturing these electrospun fiber assemblies.

Abstract: A pharmaceutical composition for treating neurodegenerative diseases of the brain is provided and including cells encapsulated by microtubular array membranes (MTAMs). The material of the microtubular array membrane is Polysulfone (PSF) or PLGA-PLLA copolymer. The cells include hybridoma cells capable of secreting anti-Tau antibodies or human umbilical cord mesenchymal stem cells (hUC-MSCs). The pharmaceutical composition could be implanted into a living body for treating neurodegenerative diseases of the brain in a subject in need thereof, in order to improve the cognitive dysfunction.

Abstract: The invention relates to a highly aligned and closely packed electrospun fiber assembly, wherein the fibers have at least an extension part or pore on the surface thereof. The invention also relates to a microtube array membrane (MTAM), comprising fiber assembly of the present disclosure. The invention also relates to the applications of these electrospun fiber assemblies in biological applications, and method of manufacturing these electrospun fiber assemblies.

Abstract: The present invention provides a porous hollow fiber membrane and methods of using the membrane to select an immune checkpoint inhibitor. The membrane can be used in animal models with an immune system and using low-cost common mouse. The host immune system is unable to attack the cancer cells within the membrane and animal study proves that the membrane system can be performed within animals.