Abstract: The invention, in part, encompasses methods to identify extrachromosomal circular DNA (ecDNA) and methods to identify and assess interactions between ecDNA and oncogene transcription.

Abstract: We identified 17 transcription factor genes that regulate lipid production and activity in an organism. We subsequently detailed characterization of one of them (psr1). Constructs, methods and systems for enhancing or increasing lipid production in an organism are described.

Abstract: We identified 17 transcription factor genes that regulate lipid production and activity in an organism. We subsequently detailed characterization of one of them (psr1). Constructs, methods and systems for enhancing or increasing lipid production in an organism are described.

Abstract: A method of determining the presence of a novel structural variation in a genome using long-read genome sequence fragments includes a process of aligning, filtering ranking and linking long-read sequence fragments against a reference genome. Presence of a novel structural variation is present in said genome can be determined when said linked alignment contains multiple linked fragments that are mapped to a single locus, referred to as a split-read.

Abstract: We identified 17 transcription factor genes that regulate lipid production and activity in an organism. We subsequently detailed characterization of one of them (psr1). Constructs, methods and systems for enhancing or increasing lipid production in an organism are described.

Abstract: We identified 17 transcription factor genes that regulate lipid production and activity in an organism. We subsequently detailed characterization of one of them (psr1). Constructs, methods and systems for enhancing or increasing lipid production in an organism are described.

Abstract: The present invention relates to mutant kinase polypeptides and kinase variants selected from the group consisting of AATYK (AATK), ABL1, ACK1, ALK, ARG, AXL, BMX, BRK, BTK, CCK4, CSFR1, CSK, DDR1, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA6, EPHA7, EPHA10, EPHB1, EPHB2, EPHB3, EPHB4, EPHB6, FAK, FER, FES, FGFR1, FGFR2, FGFR4, FLT3, FRK, FYN, HER2, HER3, HER4, IGF1R, INSR, ITK, JAK1, JAK2, JAK3, LCK, LMTK2 (AATYK2/BREK), LYN, MATK, MER, MET, NTRK1, NTRK2, NTRK3, PDGRFA, PDGFRB, PTK-9, PYK2, RET, RON, ROR1, ROR2, ROS, RYK, STYK, SYK, TEC, TEK, TIE, TNK1, TXK, TYK2, TYRO3, VEGFR1, VEGFR2, VEGFR3, YES1, and ZAP70, nucleotide sequences encoding the mutant kinase polypeptides and kinase variants, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions, including the screening for and identification of novel protein kinase modulators.

Abstract: An Operations Center (OC) (200) acts as a central key manager and intermediary in securely, reliably and non-repudiably delivering a document (3) from a sender (100) to a recipient (300). The OC (200) acts as a key manager to facilitate the process of strong authentication of the sender (100) and the recipient (300), encryption of the delivery (510), and setup of reliable connections (2A, 2B, 2C). In a preferred embodiment, the reliable connections (2A, 2B, 2C) are virtual private network connections.

Abstract: A system, method and computer readable medium for securely transmitting an information package (10) to an addressee (190) via a network (108), wherein an addressee (190) is not required to have a private-public key pair before the package (10) is sent. A sending system (102) encrypts the package (10) with a package encryption key (600) and then encrypts a package decryption key (601) with an escrow encryption key (380) obtained from an escrow key manager (116). The encrypted package (10) and encrypted package decryption key (601) are held in escrow by a server system (104), until the addressee (190) is issued a new public and private key pair (390, 391). The server system (104) decrypts the package decryption key (601), re-encrypts it with the addressee's new public key (390), and forwards the encrypted package (10) and re-encrypted package decryption key (601) to the addressee's receiving system (106). The receiving system (106) receives the delivery and decrypts the information package (10).

Abstract: Systems, methods, and computer-readable medium for securely transmitting data (400) between at least two access systems (300, 320) via a switch system (310). Through the use encryption keys and the switch system (310) acting a central switch, any two access systems are able to securely transmit data (400) between them. The present invention can be implemented by means of an application proxy (1000), a secure connection enabled application, or application program interfaces.

Abstract: An Operations Center (OC) (200) acts as a central key manager and intermediary in securely, reliably and non-repudiably delivering a document (3) from a sender (100) to a recipient (300). The OC (200) acts as a key manager to facilitate the process of strong authentication of the sender (100) and the recipient (300), encryption of the delivery (510), and setup of reliable connections (2A, 2B, 2C). In a preferred embodiment, the reliable connections (2A, 2B, 2C) are virtual private network connections.