Abstract: A sprocket capable of suppressing mud intrusion is provided. The sprocket 1 according to one embodiment is a sprocket 1, which includes a plurality of teeth and a mud discharge groove 30 that is formed to partially reduce the plate thickness and opens into the region including the tooth root center (Pbc) and the tooth tip center (Ptc) on the trailing side in the rotational direction.

Abstract: The present invention relates, generally, to methods to identity subjects responsive to p73/p63 targeting agents such as platinum-based chemotherapy agents such as, but not limited to, cisplatin and cisplatin derivatives and analogues thereof. More particularly, the present invention relates to methods to identify a cancer responsive to a p73/p63 targeting treatment, such as chemotherapeutic agents such as cisplatin, by determining if the cancer expresses and/or has the activity of p63 isoforms such as DNp63 isoforms, and expresses and/or has the activity of p73 isoforms such as TAp73 or DNp73 isoforms. The present invention also relates to methods to identify a cancer unresponsive to a p73/p63 targeting treatment, such as chemotherapeutic agents such as cisplatin by determining if the cancer lacks the expression and/or activity of p63 isoforms such as DNp63 isoforms.