Abstract: Disclosed herein is a multilayered wound dressing comprising a first layer; the first layer including channels that facilitate neovascularization of a wound; and a second layer in contact with the first layer, the second layer having the same or different chemical composition as the first layer; where the second layer comprises at least one surface that has a texture and the direction of the texture is operative to facilitate cell orientation and growth. A method includes forming a first layer of a polymeric material; forming a second layer of the same polymeric material as the first layer on the first layer; and forming a textured surface of the second layer of the same polymeric material as the first layer, the textured surface being operative to facilitate directional cell growth when used in a wound dressing, where the first layer and the second layer are formed using an additive manufacturing process.

Abstract: An article includes a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface. The first plurality of spaced features are arranged in a plurality of groupings. The groupings of features comprise repeat units, where the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features.

Abstract: Disclosed herein is a method of manufacturing a vascular graft comprising disposing cells of a first cell type on a core having a textured surface, wherein the textured surface comprises a plurality of spaced features, the spaced features being arranged in a plurality of groupings, the groupings of spaced features being arranged with respect to one another so as to define a tortuous path when viewed in a first direction; growing the cells to form a primary cell-seeded construct, wherein the primary cell-seeded construct has a textured inner surface that is a negative image of the textured surface of the core; contacting the primary cell-seeded construct with a second cell type to form a secondary cell-seeded construct; and removing the core to produce the vascular graft.

Abstract: Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid or a flow of particles suspended in a fluid or inhibit the growth or migration of cells is provided. In particular, an intraocular implant that is implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: Disclosed herein is an article including a substrate having at least one surface that has a texture and a first type of growing cells, wherein an average length of features that form the texture is operative to facilitate cell growth, cell orientation, cell morphology and cell differentiation. Disclosed herein too is a method including forming a first layer of a polymeric material on at least one surface of a substrate; texturing the first layer to form a textured first layer; and forming a first type of growing cells on the textured first layer, wherein an average length of features that form the textured first layer is operative to facilitate cell growth, cell orientation, cell morphology and cell differentiation.

Abstract: An article has a surface topography for resisting bioadhesion of organisms and includes a base article having a surface. A composition of the surface includes a polymer. The surface has a topography comprising a pattern defined by a plurality of spaced apart features attached to or projected into the base article. The plurality of features each have at least one microscale dimension and at least one neighboring feature having a substantially different geometry, wherein neighboring patterns share a common feature. The surface has an optical transmission at 400 nm to 700 nm of equal to or greater than 70%. In one embodiment, the surface can comprise a coating layer disposed on the base article.

Abstract: Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.

Abstract: Disclosed herein is a multilayered wound dressing comprising a first layer; the first layer including channels that facilitate neovascularization of a wound; and a second layer in contact with the first layer, the second layer having the same or different chemical composition as the first layer; where the second layer comprises at least one surface that has a texture and the direction of the texture is operative to facilitate cell orientation and growth. A method includes forming a first layer of a polymeric material; forming a second layer of the same polymeric material as the first layer on the first layer; and forming a textured surface of the second layer of the same polymeric material as the first layer, the textured surface being operative to facilitate directional cell growth when used in a wound dressing, where the first layer and the second layer are formed using an additive manufacturing process.

Abstract: Disclosed herein is a ventilator text fixture comprising a ventilator port that connects to a ventilator through a breathing circuit; where the ventilator delivers air through the ventilator port to a ventilator test fixture at a rate and pressure that can be controlled by a user to simulate inhalation; an input port; where the input port is in fluid communication with the ventilator port; where the input port permits additional simulated secretions or test liquids to be pumped into the ventilator text fixture; one or more bent supports; a liquid reservoir; where the liquid reservoir is operative to hold test fluids; and one or more tubes; where the one or more tubes are in fluid communication with the ventilator port and the input port via the liquid reservoir; and where the one or more bent supports are operative to mimic an anatomy of the trachea.

Abstract: Disclosed herein is an article including a path that extends across at least a portion of a surface of the article, the path being defined by at least one channel that traverses at least a portion of the surface or a first plurality of spaced features disposed on or in at least a portion of the surface; the spaced features arranged in a plurality of groupings; the groupings of features comprising repeat units; the spaced features within a grouping being spaced apart at an average distance of about 1 nanometer to about 500 micrometers to define a path that traverses the plurality of spaced features; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway.

Abstract: Disclosed herein is an article that includes a first plurality of spaced features. The spaced features are arranged in a plurality of groupings; the groupings of features include repeat units; the spaced features within a grouping are spaced apart at an average distance of about 1 nanometer to about 500 micrometers; each feature having a surface that is substantially parallel to a surface on a neighboring feature; each feature being separated from its neighboring feature; the groupings of features being arranged with respect to one another so as to define a tortuous pathway. The plurality of spaced features provide the article with an engineered roughness index of about 5 to about 20.

Abstract: Disclosed herein is a ventilator text fixture comprising a ventilator port that connects to a ventilator through a breathing circuit; where the ventilator delivers air through the ventilator port to a ventilator test fixture at a rate and pressure that can be controlled by a user to simulate inhalation; an input port; where the input port is in fluid communication with the ventilator port; where the input port permits additional simulated secretions or test liquids to be pumped into the ventilator text fixture; one or more bent supports; a liquid reservoir; where the liquid reservoir is operative to hold test fluids; and one or more tubes; where the one or more tubes are in fluid communication with the ventilator port and the input port via the liquid reservoir; and where the one or more bent supports are operative to mimic an anatomy of the trachea.

Abstract: Generally, an intraocular implant having on the external surface a plurality of pattern surface elements disposed in spaced apart relation defining a tortuous pathway adapted to control a flow of fluid, or a flow of particles suspended in a fluid, or inhibits the growth or migration of cells. In particular, an intraocular implant which implanted between an intraocular lens and the surface of the posterior capsule of the eye inhibits growth or migration of residual lens epithelial cells after cataract surgery by providing structural barriers to reduce posterior capsule opacification of the eye.