Abstract: The present disclosure provides antibody drug conjugates and methods of delivering the conjugates to effector T cells. Also disclosed are novel Cbl-b inhibitors. The compounds and conjugates are useful for treating diseases in subjects in need thereof.

Abstract: A system and a method for performing unified human motion prediction (HMP) are provided. In operation, the system provides a unified HMP module, which includes an encoder configured to encode a plurality of existing two-dimensional (2D) and three-dimensional (3D) pose sequences into a shared latent space V and a decoder configured to predict a plurality of predicted future 2D and 3D pose sequences based on the encoded shared latent space V, thus forming four pathways of knowledge flow. The system then trains the unified HMP module and the shared latent space V in a weakly supervised manner with input features X with actual future 2D and 3D pose sequences by minimizing a loss between the predicted future 2D and 3D pose sequences and the actual future 3D and 3D pose sequences. Once the training is complete, the unified HMP may be performed using the trained encoded shared latent space V.

Abstract: The present disclosure provides traceless linkers, which can link an inducer of protein-protein interaction to a cell binding agent. Also provided are compositions comprising the linked compounds. The compounds and compositions are useful for treating diseases such as cancer in subjects in need thereof.

Abstract: The present disclosure provides neoDegraders and neoDegraders conjugated to binding moieties. Also provided are compositions comprising the conjugates. The compounds and compositions are useful for treating a disease or condition, e.g., cancer, in a subject in need thereof.

Abstract: A system for three-dimensional geometric guided student-teacher feature matching includes a multi-modal teacher model configured to determine feature matching between a pair of RGB-D images, each RGB-D image being a combination of a RGB image and its corresponding depth image; a mono-modal student model configured to determine feature matching from the pair of RGB images and the teacher model, the teacher model guiding the student model to learn RGB-induced depth information for the feature matching on both coarse and fine levels; a coarse-level knowledge transfer loss function for determining loss of transferring coarse-level matching knowledge from the teacher model to the student model; and a fine-level knowledge transfer loss function for determining loss of transferring fine-level matching knowledge from the teacher model to the student model, wherein the fine-level knowledge transfer loss function guides the student model to learn a fine-level prediction distribution with priority.

Abstract: Aspects of online camera calibration for autonomous driving systems are described herein. The aspects may include a wheel odometer configured to measure a current speed of a moving vehicle, a speed monitor configured to determine that the current speed of the moving vehicle is high or low, and a camera calibrator configured to calibrate, while the vehicle is moving, at least one front camera of the moving vehicle according to a position of a vanishing point of two lane lines when the current speed is high. When the current speed is low and the vehicle is still moving, the camera calibrator may be further configured to calibrate multiple side and rear cameras of the moving vehicle according to a pose graph that includes relative poses of the multiple side and rear cameras.

Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

Abstract: The present invention generally relates to methods of preventing methionine oxidation in immunoconjugates. The present invention also relates to pharmaceutical compositions of immunoconjugates in which the amount of methionine oxidation is minimized.

Abstract: The present disclosure provides neoDegraders conjugated to anti-CD33 antibodies. Also provided are compositions comprising the conjugates. The compounds and compositions are useful for treating a disease or condition, e.g., cancer, in a subject in need thereof.

Abstract: A system and a method for performing unified human motion prediction (HMP) are provided. In operation, the system provides a unified HMP module, which includes an encoder configured to encode a plurality of existing two-dimensional (2D) and three-dimensional (3D) pose sequences into a shared latent space V and a decoder configured to predict a plurality of predicted future 2D and 3D pose sequences based on the encoded shared latent space V, thus forming four pathways of knowledge flow. The system then trains the unified HMP module and the shared latent space V in a weakly supervised manner with input features Xwith actual future 2D and 3D pose sequences by 10 minimizing a loss between the predicted future 2D and 3D pose sequences and the actual future 3 D and 3D pose sequences. Once the training is complete, the unified HMP may be performed using the trained encoded shared latent space V.

Abstract: Aspects of online camera calibration for autonomous driving systems are described herein. The aspects may include a wheel odometer configured to measure a current speed of a moving vehicle, a speed monitor configured to determine that the current speed of the moving vehicle is high or low, and a camera calibrator configured to calibrate, while the vehicle is moving, at least one front camera of the moving vehicle according to a position of a vanishing point of two lane lines when the current speed is high. When the current speed is low and the vehicle is still moving, the camera calibrator may be further configured to calibrate multiple side and rear cameras of the moving vehicle according to a pose graph that includes relative poses of the multiple side and rear cameras.

Abstract: A system for three-dimensional geometric guided student-teacher feature matching includes a multi-modal teacher model configured to determine feature matching between a pair of RGB-D images, each RGB-D image being a combination of a RGB image and its corresponding depth image; a mono-modal student model configured to determine feature matching from the pair of RGB images and the teacher model, the teacher model guiding the student model to learn RGB-induced depth information for the feature matching on both coarse and fine levels; a coarse-level knowledge transfer loss function for determining loss of transferring coarse-level matching knowledge from the teacher model to the student model; and a fine-level knowledge transfer loss function for determining loss of transferring fine-level matching knowledge from the teacher model to the student model, wherein the fine-level knowledge transfer loss function guides the student model to learn a fine-level prediction distribution with priority.

Abstract: The present invention generally relates to methods of preventing methionine oxidation in immunoconjugates. The present invention also relates to pharmaceutical compositions of immunoconjugates in which the amount of methionine oxidation is minimized.

Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

Abstract: The present invention generally relates to methods of preventing methionine oxidation in immunoconjugates. The present invention also relates to pharmaceutical compositions of immunoconjugates in which the amount of methionine oxidation is minimized.

Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

Abstract: A method of data transmission includes establishing a buffer for TCP/IP data packets, receiving and buffering the TCP/IP data packets including TCP payloads and TCP ACKs. A queue of the buffered TCP/IP data is adjusted in accordance with header information of the TCP/IP data packets. The buffered TCP/IP data packets are transmitted sequentially. The method significantly reduces the TCP ACKs, which are transmitted with priority, thereby reducing the round-trip time delay, and improving the data transmission efficiency. An apparatus configured to perform this method is also described.

Abstract: An embodiment of the present invention provides a method and apparatus for data transmission, wherein the method comprises: establishing a buffer for TCP/IP data packets, and the TCP/IP data packets including TCP payloads and TCP ACKs; adjusting a queue of the buffered TCP/IP data in accordance with header information of the TCP/IP data packets; and transmitting sequentially the buffered TCP/IP data packets being adjusted. According to the embodiments of the present invention, the IP data packets of TCP ACKs transmitted by the receiving side are processed, so that the amount of the TCP ACK responses is significantly reduced and the IP data packets of TCP ACKs are transmitted with priority, thereby the round-trip time delay for data transmitting can be reduced, and the data transmission efficiency can be improved.