Patents by Inventor Chen-Hsien Liang

Chen-Hsien Liang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIBODY PROTAC CONJUGATES
    Publication number: 20210015942
    Abstract: An immunoconjugate having the Formula Ab-[L1-(A-L2-B)m]n, wherein: (a) Ab is an antibody or a binding fragment thereof; (b) L1 and L2 are each independently a linker, wherein L1 and L2 are the same or different and wherein L1 links to L2; (c) A is a target-protein ligand/binder; (d) B is a ubiquitin ligase ligand/binder, and (e) n and m are independently integers from 1 to 8. The target protein includes kinase, G protein-coupled receptors, transcription factor, phosphatases, and RAS superfamily members.
    Type: Application
    Filed: January 9, 2019
    Publication date: January 21, 2021
    Applicant: Development Center for Biotechnology
    Inventors: Shih-Hsien Chuang, Chu-Bin Liao, Wei-Ting Sun, Chen-Hsien Liang, Wun-Huei Lin, Chun-Liang Lai, Her-Sheng Lin