Abstract: The disclosure provides a method of immunotherapy for a cancer patient, comprises administering vaccines against Globo series antigens (i.e., Globo H, Stage-specific embryonic antigen 3 “SSEA3” and Stage-specific embryonic antigen 4 “SSEA4”). Specifically, the method comprises administering Globo H-KLH (OBI-822) in patients with Metastatic Breast Cancer. The disclosure also provides a method of comprises selecting a cancer patient who is suitable as treatment candidate for immunotherapy. In addition, the disclosure provides therapeutic agents, including monoclonal antibodies (mAbs) that bind specifically to Globo series antigens and related biomarkers useful in focusing such therapeutic and diagnostic regimens.

Abstract: The disclosure provides a method of immunotherapy for a cancer patient, comprises administering vaccines against Globo series antigens (i.e., Globo H, Stage-specific embryonic antigen 3 “SSEA3” and Stage-specific embryonic antigen 4 “SSEA4”). Specifically, the method comprises administering Globo H-KLH (OBI-822) in patients with Metastatic Breast Cancer. The disclosure also provides a method of comprises selecting a cancer patient who is suitable as treatment candidate for immunotherapy. In addition, the disclosure provides therapeutic agents, including monoclonal antibodies (mAbs) that bind specifically to Globo series antigens and related biomarkers useful in focusing such therapeutic and diagnostic regimens.

Abstract: A rolling element retainer for a linear guideway, wherein the rolling groove of the connective part of the rolling elements retaining chain is composed of a loaded area and a direction changing area. At either end of the loaded-area retainer is arranged an outward extension for mating with the direction-changing-area retainer. The outward extension extends in the direction of the rolling groove of the loaded-area retainer and abuts against a projection part of the end caps of the rolling element retainer. Therefore, not only the motion stability of the linear guideway is effectively improved, but also the rolling elements can move more smoothly.

Abstract: A rolling element retainer for a linear guideway, wherein the rolling groove of the connective part of the rolling elements retaining chain is composed of a loaded area and a direction changing area. At either end of the loaded-area retainer is arranged an outward extension for mating with the direction-changing-area retainer. The outward extension extends in the direction of the rolling groove of the loaded-area retainer and abuts against a projection part of the end caps of the rolling element retainer. Therefore, not only the motion stability of the linear guideway is effectively improved, but also the rolling elements can move more smoothly.