Abstract: An antibody, or an antigen-binding fragment thereof, that binds specifically to human CSF-1R includes a heavy chain variable domain that contains a HCDR1 region having the sequence of SEQ ID NO: 4, a HCDR2 region having the sequence of SEQ ID NO: 5, and a HCDR3 region having the sequence of SEQ ID NO: 6; and a light chain variable domain that contains a LCDR1 region having the sequence of SEQ ID NO: 7, a LCDR2 region having the sequence of SEQ ID NO: 8, and a LCDR3 region having the sequence of SEQ ID NO: 9. The heavy chain variable domain comprises the sequence of SEQ ID NO: 2, and wherein the light chain variable domain comprises the sequence of SEQ ID NO: 3.

Abstract: A compound, capable of inhibiting kinases, for the treatments of diseases or disorders mediated by such kinases, has a structure of formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof. The compound can be used in the treatments of diseases or conditions mediated by CSF-1R, c-KIT, FLT3, or PDGFR kinases. Such diseases or conditions may include cancers, autoimmune diseases, and bone resorptive diseases.

Abstract: A compound, capable of inhibiting kinases, for the treatments of diseases or disorders mediated by such kinases, has a structure of formula (I): or a stereoisomer, a tautomer, a pharmaceutically acceptable salt thereof. The compound can be used in the treatments of diseases or conditions mediated by CSF-1R, c-KIT, FLT3, or PDGFR kinases. Such diseases or conditions may include cancers, autoimmune diseases, and bone resorptive diseases.

Abstract: A portable power source with removal warning function includes a large battery, a interface, a charging and discharging circuit, a wireless communication module, an alarm module; and a processor. The interface can connect to one of an external power supply and battery (ED battery) of an electronic device. The charging and discharging circuit can charge and allow discharge of the large battery and the charging of an ED battery. The wireless communication module can communicate between the portable power source and the electronic device. The processor can determine whether a distance between the portable power source and the electronic device is within or beyond a preset distance and control the alarm module to sound if the distance is beyond the preset distance.

Abstract: A power-off circuit includes a power unit (10), a power management unit (20), an integrated circuit chip (IC chip, 40), a switching apparatus (30), and a clamp circuit (70). The switching apparatus produces and transmits a power-off instruction to the power management unit. The power management unit produces and transmits a power-off notice to the IC chip in accordance with the power-off instruction. And the IC chip feeds back a power-off affirmation in accordance with the power-off notice to the clamp circuit. The clamp circuit receives the power-off affirmation and produces and transmits interrupted power-off signals to the power management unit, till the power management unit completely cuts off power supplied from the power unit to the IC chip.

Abstract: An input circuit shared by multi signal sources each of which outputting a type of signals includes a processing unit (10). The processing unit includes a plurality of input pins (11) and an interrupt pin (12), each of the input pins connecting with one or more of the signal sources and receiving signals from the signal sources. The input circuit further includes a tristate buffer (30) The tristate buffer includes an enable pin (33) enabling the tristate buffer upon receiving an enable signal, a plurality of input pins (31) connecting with one or more of the signal sources and receiving signals from the signal sources, and a plurality of output pins (32) connecting with the interrupt pin of the processing unit and producing an interrupt signal to the interrupt pin according to the signals received at the input pins. A related wake-up signal input circuit is also provided.

Abstract: An input circuit shared by multi signal sources each of which outputting a type of signals includes a processing unit (10). The processing unit includes a plurality of input pins (11) and an interrupt pin (12), each of the input pins connecting with one or more of the signal sources and receiving signals from the signal sources. The input circuit further includes a tristate buffer (30) The tristate buffer includes an enable pin (33) enabling the tristate buffer upon receiving an enable signal, a plurality of input pins (31) connecting with one or more of the signal sources and receiving signals from the signal sources, and a plurality of output pins (32) connecting with the interrupt pin of the processing unit and producing an interrupt signal to the interrupt pin according to the signals received at the input pins. A related wake-up signal input circuit is also provided.

Abstract: A multi purpose switching circuit is provided. The multi purpose switching circuit is connected with a main unit (60) of an electronic apparatus and includes a multi purpose switch (10). The multi purpose switch is capable of receiving multiple manual operational inputs and accordingly producing multiple command signals. The multiple manual operational inputs are identified by a pushing time and a pushing count in a predetermined time of the multi purpose switch. The multiple command signals initiate the main unit to implement multiple functions such as starting up, shutting down and resetting itself. An electronic device including such a multi purpose switching circuit is also provided.

Abstract: A power-off circuit includes a power unit (10), a power management unit (20), an integrated circuit chip (IC chip, 40), a switching apparatus (30), and a clamp circuit (70). The switching apparatus produces and transmits a power-off instruction to the power management unit. The power management unit produces and transmits a power-off notice to the IC chip in accordance with the power-off instruction. And the IC chip feeds back a power-off affirmation in accordance with the power-off notice to the clamp circuit. The clamp circuit receives the power-off affirmation and produces and transmits interrupted power-off signals to the power management unit, till the power management unit completely cuts off power supplied from the power unit to the IC chip.