Abstract: The present disclosure relates generally to lipids, lipid nanoparticle formulations, and methods of using the same for delivering nucleic acids, such as mRNA.

Abstract: A method for automatically classifying clinical descriptions of patients by a computer processor using natural language processing is provided. The clinical descriptions relate to the use of a ventricular assist device to treat the patient. The method comprises receiving at least one clinical description comprising text. The method also then comprises determining the position of a target word within the text. Further the method comprises determining the existence of at least one negation word within an active region, the active region comprising a predetermined number of words within the text occurring immediately before and immediately after the target word, including the target word. The method then comprises determining the existence of at least one body-part word within the active region. Lastly, the method comprises determining that the clinical description is to be disregarded if the active region contains either a negation word or a body-part word.

Abstract: A small molecular compound has a substituted phenylspiro[indoline-3,3?-pyrrolidine]structure. The compound is of formula I. The compound can inhibit the protein-protein interaction between MDM2-p53 and MDMX-p53, is used as a small molecular inhibitor for the protein-protein interaction between MDM2-p53 and MDMX-p53, and is used in the preparation of a drug for preventing and/or treating diseases related to MDM2 and MDMX, especially tumors.

Abstract: A method for providing a treatment recommendation to a physician for treating a patient is disclosed. The method comprises determining, from a processor in communication with a patient data repository, a first treatment recommendation based on a combination of selected patient demographics from the patient data repository applicable to the patient, and operational parameters of a plurality of ventricular assist devices (VADs) suitable for treating the patient, the first treatment recommendation having a first survival rate and comprising the use of a first VAD. The method then obtains a first signal from using the first VAD on the patient. The method then determines a second treatment recommendation based on the first signal and the first treatment recommendation, the second treatment recommendation having a second survival rate. The method then provides the second treatment recommendation to the physician if the second survival rate is higher than the first survival rate.

Abstract: In some embodiments, a method generates a first pattern and corresponding first bit string for a first location and searches storage for patterns that were previously determined from transcoding locations and can be reused for the first location. A second pattern and corresponding second bit string for a second location is selected from storage. The second pattern is different from the first pattern. The method determines information for an alteration of the second pattern to the first pattern. Then, the method includes the information for the alteration in an encoded bitstream for use in decoding the first location.

Abstract: Embodiments of this specification disclose a method and apparatus for detecting intrusion, a storage medium and a device. In this method, a pointcut is set in a dynamic link library of a JVM, a corresponding aspect is initiated at an operating system kernel layer. When the aspect is triggered, the operating system kernel queries, by stack information, a method that is invoked in the dynamic link library by a target event triggering the aspect, and accordingly detects whether the target event is an intrusion event. Since in this method, an intrusion event is detected by a system layer, a system invocation generated by the intrusion can be sensed, even if an intruder directly intruded from a JDWP protocol layer, thereby effectively defending against the event.

Abstract: A real-time vector analysis method for detecting an optical signal with a bandwidth greater than 1 THz includes: mapping, by a time-lens focusing system, a spectrum of a signal under test to different temporal location information; obtaining, by fully broadening an ultrashort pulse by a dispersion, a time domain spectrum of the ultrashort pulse to form a chirped swept frequency source; inputting an out of the signal under test after passing through the time-lens and the chirped swept frequency source to a coherent receiver to realize an interference process and a conversion of an optical signal to an electrical signal, and recovering an intensity information and a phase information of frequency domain of the signal under test from the electrical signal by data acquisition and processing; then recovering a full-field information of time domain of the signal under test by a Fourier inverse transform.

Abstract: A communication method includes: a network device receiving first information from at least one device; and determining second information based on the first information, in which the at least one device including a first device and/or a second device, the first information is data channel negotiation result information of the at least one device, and the second information is data channel indication information.

Abstract: Provided are an intelligent safety monitoring system and method. The intelligent safety monitoring system includes: a monitoring unit configured to monitor status information of a vehicle; a control unit connected to the monitoring unit and configured to determine, based on the status information of the vehicle, whether an abnormality occurs on the vehicle; a camera unit connected to the control unit and configured to obtain surrounding environment information of the vehicle based on a control instruction output by the control unit when the control unit determines that the abnormality occurs; and a mobile terminal communicatively connected to the control unit and configured to receive and output the status information of the vehicle and/or an abnormality determination result and the surrounding environment information that are sent by the control unit.

Abstract: In some embodiments, a method receives an image to analyze for artifacts. Texture information that characterizes texture in the image is determined. The method merges the texture information with the image. The texture information is used to focus an analysis of artifacts in regions of the image. The method outputs a score based on the processing of the image that assesses the artifacts in the image.

Abstract: A ball spline device includes a spline shaft, the outer side wall provided with raceway grooves extending in the axial direction, each raceway groove comprising, a first groove section and a second groove section, and the width of the second groove section being greater than that of the first groove section; a spline nut coaxially fitted over the spline shaft; and first rolling bodies. When the spline nut is located at a first position, the first rolling bodies are located in the first groove sections and in constraint fit with the first groove sections; and when the spline nut is located at a second position, the first rolling bodies are located in the second groove sections, such that the spline nut and the spline shaft have a preset movement amount in the circumferential direction. Further provided are an automated guided vehicle and a stereoscopic warehouse system.

Abstract: In some embodiments, a method includes inputting a proxy encoding configuration into an encoder. This encoder determines proxy quality values from an actual encoding of a portion of a video. These proxy quality values are for a set of bitrates and a resolution. The method also determines target feature values for the same portion of the video. The method inputs both the target feature values and a target configuration into a prediction network. This network generates a plurality of quality offset values for the set of bitrates and the resolution. The prediction network is configured to predict an offset to the proxy quality values. This offset is determined based on a difference between the proxy encoding configuration and the target configuration. The method then generates a plurality of quality values. The generation uses the plurality of proxy quality values and the corresponding plurality of quality offset values.

Abstract: In some embodiments, a method receives a first video and processes frames of the first video to generate a second video. A frame matching process is performed to determine whether frames of the second video and frames of the first video meet a condition that determines whether frames match to generate a new version of the second video and a new version of the first video. A sequence of frames in the new version of the first video is different from the first video. The method compares frames of the new version of the second video and frames of the new version of the first video to generate a score based on a quality metric.

Abstract: Various examples relate to a non-transitory computer-readable medium, a method, an apparatus and a computer program for a firmware of a computer system to mitigate power telemetry side-channel attacks. The method comprises obtaining a first energy consumption value related to an energy consumption of a processor for a first time window, obtaining a second energy consumption value related to the energy consumption of the processor for a second time window, wherein the second time window has a different length than the first time window, wherein the first and second time window overlap, and generating a modified energy consumption value based on the first energy consumption value and the second energy consumption value to protect against telemetry-based side-channel attacks.

Abstract: A method and a system for personalized image generation are provided. The method includes: determining a facial description text specified by a user; generating, based on the facial description text, a facial image by using a generative algorithm; obtaining a first dressing effect image of a target garment, the first dressing effect image presenting a wearing effect of the target garment on a digital model; and generating a second dressing effect image of the target garment by performing a fusion operation on the facial image and the first dressing effect image, the second dressing effect image presenting a wearing effect of the target garment on a fused digital model. The provided solution not only enables the rapid, high-quality generation of garment images but also ensures that the fused images maintain feature consistency, meeting users' personalized display preferences.

Abstract: Methods and systems for interactive athletic training and gaming using wireless technology. A computer-implemented method includes receiving one or more data signals from at least one user device having instructions to initiate a preset mode, monitoring, using a plurality of sensors, an aperture of a goal post system according to the preset mode, determining, using the plurality of sensors, whether a target object passed through the aperture, and upon determining that the target object passed through the aperture, performing an action based on the preset mode. A goal post system includes a crossbar, at least one mounting body coupled to the crossbar body defining an aperture, a plurality of sensors coupled to the at least one mounting body and the crossbar body, a wireless communication module coupled to the plurality of sensors, and a controller including a processor and coupled to the crossbar body.

Abstract: Systems and methods are provided herein for estimating a position of a heart pump system in a patient. The system receives first data indicative of a time-varying motor current during a first time period. The motor current corresponds to an amount of current delivered to a motor, while the heart pump system is operating in the patient. The system receives second data indicative of a time-varying differential pressure during the first time period. The differential pressure is indicative of a position of the heart pump system relative to patient's heart. The system receives third data indicative of time-varying motor current during a second time period, and determines an estimate of differential pressure during the second period of time from the third data and a relationship between the first data and the second data. The estimate is usable to predict the position of the heart pump system in the patient.

Abstract: The present disclosure relates generally to lipids, lipid nanoparticle formulations, and methods of using the same for delivering nucleic acids, such as mRNA.

Abstract: In some embodiments, a method transcodes a first location from a spatial region. The first location is associated with a first pattern defining a structure of splitting a location into smaller shapes. A bit string of bits is included for the first pattern in an encoded bitstream. The method determines the first location in the spatial region when the first pattern of the first location can be reused for a second pattern of a second location. The first location is one of a plurality of locations in the spatial region. Information for the second location is included in the encoded bitstream that indicates the first location in the spatial region without including a bit string of bits for the second pattern. The first location allows the bit string of bits for the first pattern to be retrieved for use to decode the second location from the encoded bitstream.