Abstract: Embodiments described herein relate to systems and methods of retinal injection. In some aspects, a method includes inserting a distal end portion of a hollow conduit of a medical injector into an eye of a patient until the distal end portion reaches a reference location, the medical injector having a housing from which the hollow conduit distally extends and confirming disposal of the distal end portion of the hollow conduit in the reference location. After the confirming, the method further includes extending the distal end portion of the hollow conduit distally relative to the housing and from the reference location such that the distal end portion enters an injection region of the eye. With the distal end portion of the hollow conduit disposed in the injection region of the eye, medicament is conveyed into the injection region via the hollow conduit.

Abstract: The present disclosure describes a medical construct. The medical construct includes a first layer comprising an array of collagen fibers, the first layer forming a core of the medical construct, and a second layer comprising a plurality of braided collagen fibers, wherein the second layer surrounds the core of the medical construct. In some embodiments, the medical construct may further include a third layer comprising a plurality of braided collagen fibers, wherein the third layer surrounds the second layer. Methods of manufacturing a medical construct also provided.

Abstract: Embodiments disclosed include fabrication and use of a three-dimensional, multi-compartmental anatomical model of a portion of an eye.

Abstract: The present disclosure describes a medical construct. The medical construct includes a first layer comprising an array of collagen fibers, the first layer forming a core of the medical construct, and a second layer comprising a plurality of braided collagen fibers, wherein the second layer surrounds the core of the medical construct. In some embodiments, the medical construct may further include a third layer comprising a plurality of braided collagen fibers, wherein the third layer surrounds the second layer. Methods of manufacturing a medical construct also provided.

Abstract: A method of repairing a partial or complete ACL tear using a biologically active suture combined with a suture anchor. The biologically active material may be an angiogenic material that provides a biological stimulus (such as blood vessel growth) to initiate the repair cascade throughout the tear.

Abstract: Methods, systems and activated human mesenchymal stromal cells (hMSCs) from bone marrow regions distal from bone fractures, the hMSCs enhanced for encouraging healing of bone fractures. Systems and methods of activation for enhancing bone fracture healing hMSCs, and the enhanced cells themselves, by exposing and activating distally obtained bone marrow aspirate to acoustic energy prior to placement of the activated cells at a site of a bone fracture.