Abstract: A compound, as represented by formula I, as a TLR7 agonist, a method for preparing the compound, and the use of the compound in treating diseases mediated by the TLR7 agonist are provided. Studies on the activity of a human-derived receptor, a TLR7 agonist, show that compounds have a strong agonistic effect on the human-derived receptor, TLR7, and can be used as a foreground compound for treating diseases mediated by the TLR7 agonist.

Abstract: The invention provides a recombinant Escherichia coli strain for producing succinic acid and a construction method thereof. The by-product encoding genes in the E. coli strain FMME-N-2 are knocked out to obtain the E. coli strain FMME-N-5 (?focA-pflB-?ldhA-?pta-ackA); and the phosphoenolpyruvate carboxykinase pck derived from Actinobacillus succinogenes and the phosphite dehydrogenase ptxD derived from Pseudomonas stutzeri were overexpressed. The constructed plasmid pTrcHisA-pck-ptxD was introduced into the expression host E. coli FMME-N-5 (?focA-pflB-?ldhA-?pta-ackA), and the cells were screened in a plate containing ampicillin, to obtain an engineered strain E. coli FMME-N-5 (?focA-pflB-?ldhA-?pta-ackA)-pck-ptxD that can efficiently produce succinic acid. After fermentation by a two-stage fermentation strategy, the production of succinic acid reaches 137 g/L, the yield of succinic acid is up to 1 g/g glucose, and the space time yield is 1.

Abstract: Photovoltaic devices having contact layers are described herein. Devices, intermediate structures, and methods for making multilayer contacts for perovskite photovoltaic devices are provided. Embodiments include back contacts for N-I-P structures.

Abstract: Methods and compositions for forming perovskite hole transport layers for use in manufacturing photovoltaic devices are described. Embodiments include using a plurality of hole transport materials to produce high-performance HTL contacts to improve performance and stability.

Abstract: The present disclosure provides methods for preparing a target mutant nucleic acid for subsequent enrichment relative to a wild-type nucleic acid using nucleases that have a substantially higher activity on double stranded DNA versus single stranded DNA or RNA. The present disclosure also includes methods for enriching a target mutant nucleic acid and for preparing unmethylated/methylated nucleic acids of interest for subsequent enrichment.

Abstract: An operation apparatus for a rotary switch and a rotary switch relate to the field of switch technologies. The operation apparatus for a rotary switch includes a motion member and a fastener having an accommodating cavity. The motion member passes through the accommodating cavity, and the motion member is driven to move in the accommodating cavity and can be switched between a lock position and a working position. The lock position restricts rotation of the motion member. When the motion member is in the working position, a release can be reset under action of the motion member. The operation apparatus for the rotary switch provides for reliable reset of the release.

Abstract: A rotary operator and a rotary switch are disclosed, relating to the technical field of switches. The rotary operator includes a handle, a fastening base, and a pressing component. The fastening base is provided with an accommodation cavity. A transmission end of the handle is inserted in the accommodation cavity and is capable of relatively rotating in the accommodation cavity. The pressing component is sleeved on the transmission end of the handle and is slidably connected to the fastening base. The handle is pushed to move along an axis of the accommodation cavity, so that the pressing component moves relative to the fastening base to be in contact with or be separated from a tripper of a circuit breaker. The rotary operator can reset the tripper of the circuit breaker easily after a switching operation is completed.

Abstract: Provided are an authentication method and apparatus, a device, and a storage medium. The method includes, if an optical line terminal operates in at least two bands, setting at least one low-delay band and at least one non-low-delay band; after receiving, in a non-low-delay band, a first serial number sent by an optical network unit (ONU) or an auxiliary authentication device, acquiring an equalization delay; after receiving, in the non-low-delay band, an authentication request sent by the ONU or the auxiliary authentication device, determining an ONU identifier according to the first serial number or a second serial number of the ONU in a low-delay band, where the second serial number is sent by the ONU in the non-low-delay band; and authenticating the ONU according to the ONU identifier and the equalization delay.

Abstract: The present disclosure provides methods for preparing a target mutant nucleic acid for subsequent enrichment relative to a wild type nucleic acid using nucleases that have a substantially higher activity on double stranded DNA versus single stranded DNA or RNA. The present disclosure also includes methods for enriching a target mutant nucleic acid and for preparing unmethylated/methylated nucleic acids of interest for subsequent enrichment.

Abstract: Provided are a solid oxide fuel cell/electrolytic cell and electric stack, which relate to the field of cells. A metal support frame is molded in one step or more steps through the additive manufacturing technology. And then a fuel/electrolytic cell functional layer is formed on the metal support frame by means of thermal spraying, tape casting, screen printing or chemical vapor deposition method, and self-sealing of the solid oxide fuel cell/electrolytic cell is realized through a dense structure of electrolyte.

Abstract: Provided are a solid oxide fuel cell/electrolytic cell and electric stack, which relate to the field of cells. A metal support frame is molded in one step or more steps through the additive manufacturing technology. And then a fuel/electrolytic cell functional layer is formed on the metal support frame by means of thermal spraying, tape casting, screen printing or chemical vapor deposition method, and self-sealing of the solid oxide fuel cell/electrolytic cell is realized through a dense structure of electrolyte.

Abstract: An instruction execution method suitable for being executed by a processor is provided. The first processor comprises a register alias table (RAT) and a reservation station. The instruction execution method includes: a register alias table receives a first micro-instruction and a second micro-instruction and issues the first micro-instruction and the second micro-instruction to the reservation station; and the reservation station assigns one of a plurality of execution units to execute the first micro-instruction, according to the first specific message of the first micro-instruction; and the reservation station assigns one of the execution units to execute the second micro-instruction, according to the second specific message of the second micro-instruction.

Abstract: A digital-to-analog conversion circuit, a digital-to-analog conversion method, and a display device are provided. The digital-to-analog conversion circuit includes a first digital-to-analog conversion sub-circuit and a second digital-to-analog conversion sub-circuit. The second digital-to-analog conversion sub-circuit includes least-significant-bit voltage selection modules whose quantity is a, a weighed summation operational amplifier, switching control modules whose quantity is a and energy storage modules whose quantity is a. The weighted summation operational amplifier includes a reverse-phase input end, an operational amplification output end, and same-phase input ends whose quantity is a. The reverse-phase input end is connected to the operational amplification output end, and a is an integer greater than 1.

Abstract: Digital-to-analog conversion circuit, digital-to-analog conversion method, display apparatus are disclosed.

Abstract: An image display drive device, a display device and an electrical compensation method are disclosed. The image display drive device includes a detection circuit and a data superposition circuit. The detection circuit is configured to obtain an electrical compensation data signal of a display panel; the data superposition circuit is configured to superpose the electrical compensation data signal and the initial driving data signal, so as to obtain a compensated driving data signal.

Abstract: A digital-to-analog conversion circuit, a digital-to-analog conversion method, and a display device are provided. The digital-to-analog conversion circuit includes a first digital-to-analog conversion sub-circuit and a second digital-to-analog conversion sub-circuit. The second digital-to-analog conversion sub-circuit includes least-significant-bit voltage selection modules whose quantity is a, a weighed summation operational amplifier, switching control modules whose quantity is a and energy storage modules whose quantity is a. The weighted summation operational amplifier includes a reverse-phase input end, an operational amplification output end, and same-phase input ends whose quantity is a. The reverse-phase input end is connected to the operational amplification output end, and a is an integer greater than 1.

Abstract: An image display drive device, a display device and an electrical compensation method are disclosed. The image display drive device includes a detection circuit and a data superposition circuit. The detection circuit is configured to obtain an electrical compensation data signal of a display panel; the data superposition circuit is configured to superpose the electrical compensation data signal and the initial driving data signal, so as to obtain a compensated driving data signal.

Abstract: Embodiments of the present disclosure provide a digital-to-analog converter, a conversion circuit and a display device. An M-bit digital-to-analog converter includes a higher M?N-bit digital-to-analog conversion circuit, a voltage conversion circuit, an output circuit. The higher M?N-bit digital-to-analog conversion circuit includes: a higher M?N-bit voltage division generation circuit, a first voltage selection circuit. The first voltage selection circuit selects a first voltage from the higher M?N-bit voltage division generation circuit based on a higher M?N-bit digital signal, to be output from a first voltage end. The voltage conversion circuit charges a capacitor circuit under the control of a first switch circuit and a second switch circuit, and discharges a second voltage to a second voltage end through the capacitor circuit.

Abstract: Digital-to-analog conversion circuit, digital-to-analog conversion method, display apparatus are disclosed.

Abstract: Provided are an external compensation circuit and method, and display device in the field of display techniques. The external compensation circuit includes a regulation sub-circuit that may collect a driving current loaded to a light-emitting unit and a reference current from a reference current source, and regulate potentials at two nodes connected to a compensation sub-circuit according to the collected current, to enable the compensation sub-circuit to calibrate a data signal to be input to a pixel circuit according to a potential difference between the two nodes.