Patents by Inventor Chen Wang Liaw

Chen Wang Liaw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Corticotropin-releasing factor receptors
    Patent number: 7034118
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: April 25, 2006
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Timothy W Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E Grigoriadis, Derek T Chalmers, Errol B DeSouza
  • Human N-methyl-D-aspartate receptor subunits nucleic acids encoding same and uses therefor
    Patent number: 6956102
    Abstract: Provided herein are nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. In one aspect of the invention, the nucleic acids encode provides In a preferred embodiment, the invention nucleic acids encode MNDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. The disclosed nucleic acids are also useful as probes, thus enabling those skilled in the art, to identify and isolate related human receptor subunits. Functional glutamate receptors can be assembled, in accordance with the present invention, from a plurality of one type of NMDA receptor subunit protein (homomeric) or from a mixture of two or more types of subunit proteins (heteromeric). Also provided are methods for using the disclosed receptor subunits to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.
    Type: Grant
    Filed: September 4, 2001
    Date of Patent: October 18, 2005
    Assignee: Merck & Co., Inc.
    Inventors: Lorrie P. Daggett, Steven B. Ellis, Chen Wang Liaw, Chin-Chun Lu
  • Corticotropin-releasing factor2 receptors
    Publication number: 20040185533
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Application
    Filed: April 9, 2004
    Publication date: September 23, 2004
    Applicant: Neurocrine Biosciences, Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Derek T. Chalmers, Errol B. DeSouza
  • Corticotropin-releasing factor2 receptors
    Patent number: 6723841
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: April 20, 2004
    Assignee: Neurocrine Biosciences Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Derek T. Chalmers, Errol B. DeSouza
  • Human N-methyl-D-aspartate receptor subnits, nucleic acids encoding same and uses therefor
    Patent number: 6521413
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor subunit proteins, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits.
    Type: Grant
    Filed: August 30, 1999
    Date of Patent: February 18, 2003
    Assignee: Merck & Co., Inc.
    Inventors: Lorrie P. Daggett, Steven B. Ellis, Chen Wang Liaw, Chin-Chun Lu
  • Human N-methyl-D-aspartate receptor subunits, nucleic acids encoding same and uses therefor
    Publication number: 20020161215
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor subunit proteins, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits.
    Type: Application
    Filed: September 4, 2001
    Publication date: October 31, 2002
    Inventors: Lorrie P. Daggett, Steven B. Ellis, Chen Wang Liaw, Chin-Chun Lu
  • Corticotropin-releasing factor2 receptors
    Publication number: 20020077468
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Application
    Filed: June 13, 2001
    Publication date: June 20, 2002
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Derek T. Chalmers, Errol B. DeSouza
  • Interleukin-1 type 3 receptors
    Patent number: 6239268
    Abstract: The present invention provides isolated nucleic acid molecules encoding soluble and membrane bound forms of Interleukin-1 Type 3 receptors, as well as recombinant expression vectors and host cells suitable for expressing such receptors.
    Type: Grant
    Filed: January 8, 1999
    Date of Patent: May 29, 2001
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, William R. Clevenger, Errol B. DeSouza
  • Human n-methyl-d-aspartate receptor type 1 subunits, DNA encoding same and uses therefor
    Patent number: 6033865
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A and NMDAR2C subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor subunit proteins, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: March 7, 2000
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Lorrie P. Daggett, Steven B. Ellis, Chen Wang Liaw
  • Methods for identifying compounds that modulate the activity of human N-methyl-D-aspartate receptors
    Patent number: 5985586
    Abstract: In accordance with the present invention, there are provided nucleic acids encoding human NMDA receptor protein subunits and the proteins encoded thereby. The NMDA receptor subunits of the invention comprise components of NMDA receptors that have cation-selective channels and bind glutamate and NMDA. In one aspect of the invention, the nucleic acids encode NMDAR1 and NMDAR2 subunits of human NMDA receptors. In a preferred embodiment, the invention nucleic acids encode NMDAR1, NMDAR2A, NMDAR2B, NMDAR2C and NMDAR2D subunits of human NMDA receptors. In addition to being useful for the production of NMDA receptor subunit proteins, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: November 16, 1999
    Assignee: Sibia Neurosciences, Inc.
    Inventors: Lorrie P. Daggett, Steven B. Ellis, Chen Wang Liaw, Chin-Chun Lu
  • Isolated nucleic acid encoding corticotropin-releasing factor.sub.2 receptors
    Patent number: 5786203
    Abstract: The present invention provides isolated nucleic acid molecules encoding CRF.sub.2 receptors, recombinant expression vectors and host cells suitable for expressing such receptors, as well as compositions and methods which utilize such receptors.
    Type: Grant
    Filed: January 31, 1995
    Date of Patent: July 28, 1998
    Assignee: Neurocrine Biosciences, Inc.
    Inventors: Timothy W. Lovenberg, Tilman Oltersdorf, Chen Wang Liaw, Dimitri E. Grigoriadis, Errol DeSouza