Abstract: An electrical connector includes an insulative housing extending in a horizontal direction, a plurality of conductive terminals retained in the insulative housing, a metallic stiffener surrounding the insulative housing, a load plate pivotally mounted upon the metallic stiffener and moveable between an open position and a closed position, and a carrier frame used for retaining and receiving a central processing unit (CPU) and carrying the CPU to the insulative housing. After retaining the CPU, the carrier frame is mounted on the insulative housing along a vertical direction perpendicular to the horizontal direction. The load plate is rotated to the closed position to fix the CPU on the insulative housing.

Abstract: A light-emitting device includes: a semiconductor stack, including a first semiconductor layer, an active region and a second semiconductor layer; a first contact electrode and a second contact electrode formed on the semiconductor stack, wherein the first contact electrode includes a first contact part formed on the first semiconductor layer and the second contact electrode includes a second contact part formed on the second semiconductor layer; an insulating stack formed on the semiconductor stack, including an opening on the second contact part; a first electrode pad and a second electrode pad formed on the insulating stack, wherein the second electrode pad filled in the opening and connecting the second contact part; wherein the second electrode pad includes an upper surface, and the upper surface includes a platform area and a depression area on the second contact part; wherein the platform area has a maximum height relative to other areas of the upper surface; wherein an area of a projection of the plat

Abstract: The present invention generally relates to the field of ionizable (also termed cationic) lipids, and in particular provides a novel type of such lipids as represented by formula (I). The present invention further provides methods for making such lipids as well as uses thereof, in particular in the preparation of nanoparticle compositions, more in particular nanoparticle compositions comprising nucleic acids. It further provides vaccine formulations comprising nanoparticle compositions based on the ionizable lipids disclosed herein.

Abstract: The present disclosure relates to a halogen free flame retardant elastomer composition, a halogen free flame retardant article prepared from the same, and preparation methods thereof.

Abstract: The present invention relates to anti-matriptase antibodies and immunoconjugates of anti-matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising an anti-matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.

Abstract: There is provided a method for managing a solid state storage system with hybrid storage technologies. The method includes monitoring one or more storage request streams to identify operating mode characteristics therein from among a set of possible operating mode characteristics. The set of possible operating mode characteristics correspond to a set of available operating modes of the hybrid storage technologies. The method further includes identifying a current operating mode from among the set of available operating modes responsive to the identified operating mode characteristics. The method also includes predicting a likely future operating mode responsive to variations in workload requirements to generate at least one future operating mode prediction. The method additionally includes controlling at least one of data placement, wear leveling, and garbage collection, responsive to the at least one future operating mode prediction.

Abstract: There is provided a method for managing a solid state storage system with hybrid storage technologies. The method includes monitoring one or more storage request streams to identify operating mode characteristics therein from among a set of possible operating mode characteristics. The set of possible operating mode characteristics correspond to a set of available operating modes of the hybrid storage technologies. The method further includes identifying a current operating mode from among the set of available operating modes responsive to the identified operating mode characteristics. The method also includes predicting a likely future operating mode responsive to variations in workload requirements to generate at least one future operating mode prediction. The method additionally includes controlling at least one of data placement, wear leveling, and garbage collection, responsive to the at least one future operating mode prediction.

Abstract: The present invention relates to anti-matriptase antibodies and immunoconjugates of anti-matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising an anti-matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.

Abstract: A method for managing a network queue memory includes receiving sensor information about the network queue memory, predicting a memory failure in the network queue memory based on the sensor information, and outputting a notification through a plurality of nodes forming a network and using the network queue memory, the notification configuring communications between the nodes.

Abstract: The present invention relates to matriptase antibodies and immunoconjugates of matriptase antibodies with cytotoxic agents and the use thereof for killing or inhibiting the growth of matriptase-expressing cancer cells, such as those of multiple myeloma and breast cancers. In particular, immunoconjugates comprising a matriptase monoclonal antibody and anticancer agents such as auristatin, including monomethyl auristatin E (MMAE) and monomethyl auristatin F (MMAF) are introduced, which have potent antitumor activity in vivo. Moreover, importantly; there was no weight loss or other evidence of toxicity in the animals, indicating that no significant free drug was released into the circulation from the conjugate. The present invention also provides compositions comprising these new immunoconjugates and use of them for treatment of malignancies comprising cells that express matriptase.

Abstract: An integrated circuit (IC) includes: a plurality of hardware performance counters; a thermal sensor; and a micro-controller. The micro-controller generates a plurality of thermal predictors based on values of the counters and temperatures sensed by the thermal sensor. The thermal predictors include first and second rising thermal delta predictors to predict rising temperature deltas and first and second falling thermal delta predictors to predict falling temperature deltas. The micro-controller predicts a future temperature of the IC based on an idle temperature of the IC and a selected one of the temperature deltas.

Abstract: A system and method for determining reliability-aware runtime optimal processor configuration can integrate soft and hard error data into a single metric, referred to as the balanced reliability metric (BRM), by using statistical dimensionality reduction techniques. The BRM can be used to not only adjust processor voltage to optimize overall reliability but also to adjust the number of on-cores to further optimize overall processor reliability. In some implementations, both coarse-grained actuations, based on optimal core count, and fine-grained actuations, based on optimal processor voltage (Vdd), may be used, where feedback control can recursively re-compute soft and hard error data based on a new configuration, until convergence at an optimal configuration.

Abstract: A method and circuit of monitoring an effective age of a target circuit are provided. A standby mode is activated in the target circuit. A standby current of a first number of circuit blocks of the target circuit is measured. The measured standby current of the first number of circuit blocks is compared to a first baseline standby current of the first number of circuit blocks. Upon determining that the measured standby current of the first number of circuit blocks is below a first predetermined factor of a baseline standby current of the first number of circuit blocks, the first number of circuit blocks is identified to have a bias temperature instability (BTI) degradation concern.

Abstract: A system and method for determining reliability-aware runtime optimal processor configuration can integrate soft and hard error data into a single metric, referred to as the balanced reliability metric (BRM), by using statistical dimensionality reduction techniques. The BRM can be used to not only adjust processor voltage to optimize overall reliability but also to adjust the number of on-cores to further optimize overall processor reliability. In some implementations, both coarse-grained actuations, based on optimal core count, and fine-grained actuations, based on optimal processor voltage (Vdd), may be used, where feedback control can recursively re-compute soft and hard error data based on a new configuration, until convergence at an optimal configuration.

Abstract: An aspect includes optimizing an application workflow. The optimizing includes characterizing the application workflow by determining at least one baseline metric related to an operational control knob of an embedded system processor. The application workflow performs a real-time computational task encountered by at least one mobile embedded system of a wirelessly connected cluster of systems supported by a server system. The optimizing of the application workflow further includes performing an optimization operation on the at least one baseline metric of the application workflow while satisfying at least one runtime constraint. An annotated workflow that is the result of performing the optimization operation is output.

Abstract: According to an aspect, a method for triggering creation of a checkpoint in a computer system includes executing a task in a processing node of the computer system. A monitoring block size is determined for the checkpoint. A checkpoint interval is determined based on the monitoring block size, a checkpoint bandwidth, and a failure rate of the computer system. Based on determining that the checkpoint interval has elapsed, the checkpoint including state data of the task is created to enable restarting execution of the task upon a restart operation. The state data of the checkpoint is restored from a memory responsive to detecting an error condition at the processing node. Execution of the task is restarted in the processing node based on the state data restored from the memory.

Abstract: An integrated circuit (IC) includes: a plurality of hardware performance counters; a thermal sensor; and a micro-controller. The micro-controller generates a plurality of thermal predictors based on values of the counters and temperatures sensed by the thermal sensor. The thermal predictors include first and second rising thermal delta predictors to predict rising temperature deltas and first and second falling thermal delta predictors to predict falling temperature deltas. The micro-controller predicts a future temperature of the IC based on an idle temperature of the IC and a selected one of the temperature deltas.

Abstract: A method is disclosed, as well as an associated apparatus and computer program product, for checkpointing using a plurality of communicatively coupled compute nodes. The method comprises acquiring health information for a first node of the plurality of compute nodes, and determining a first failure probability for the first node using the health information. The first failure probability corresponds to a predetermined time interval. The method further comprises selecting a second node of the plurality of compute nodes as a partner node for the first node. The second node has a second failure probability for the time interval. A composite failure probability of the first node and the second node is less than the first failure probability. The method further comprises copying checkpoint information from the first node to the partner node.