Abstract: It relates to the field of molecular biology, and specifically to an isolated nuclease and the use thereof. It further specifically relates to: a nucleic acid and a nucleic acid construct encoding the nuclease, a guide RNA and a nucleic acid construct thereof, and a composition, a recombinant vector, a recombinant host cell and a kit comprising the nuclease. It further specifically relates to: a method for introducing a double-strand break into a targeting gene of a host cell, a method for deleting, replacing or inserting a targeting gene of a host cell, and a method for obtaining a host cell in which a targeting gene is deleted, replaced or inserted.

Abstract: A three dimensional circuit module can include: a plurality of PCBs located on different faces, where surfaces of the PCBs include circuit modules; a plurality of circuit assemblies connected through components; where the plurality of circuit assemblies comprises at least one first circuit assembly having a first main board and at least one first side board that are located on different faces, where the first main board and at least one first side board of the first circuit assembly are obtained by integrated curing molding process; and where the first main board of the first circuit assembly is located on one PCB board, and the first side board is located on an adjacent PCB board, in order to realize connection of adjacent PCBs.

Abstract: An integrated circuit can include: a bottom structure; at least one GaN transistor die, where each GaN transistor die includes at least one power switching device; a silicon die including a control circuit for controlling the power switching device; and where the GaN transistor die and the silicon die are arranged on the bottom structure, and an electrical connection between the control circuit and the power switching device includes corresponding patterned metal structures arranged in the bottom structure.

Abstract: A wearable device includes a first radiation metal element, a second radiation metal element, a ground metal element, a third radiation metal element, and a carrier element. The first radiation metal element is coupled to a positive feeding point. The second radiation metal element is coupled to the positive feeding point. The ground metal element is coupled to a negative feeding point. The third radiation metal element is adjacent to the ground metal element. A coupling gap is formed between the third radiation metal element and the ground metal element. The first radiation metal element, the second radiation metal element, the ground metal element, and the third radiation metal element are disposed on the carrier element. An antenna structure is formed by the first radiation metal element, the second radiation metal element, the ground metal element, and the third radiation metal element.

Abstract: An antenna structure includes a feeding radiation element, a first radiation element, a second radiation element, a third radiation element, and a carrier element. The feeding radiation element has a feeding point. The first radiation element is coupled to the feeding radiation element. The first radiation element has a meandering structure. The second radiation element is coupled to the feeding radiation element. The second radiation element is adjacent to the first radiation element. The third radiation element is coupled to the ground voltage. The third radiation element is adjacent to the second radiation element. The feeding radiation element, the first radiation element, the second radiation element, and the third radiation element are disposed on the carrier element.

Abstract: Provided is a data augmentation system including at least one processor configured to: acquire a first search query including a first named entity, which was actually input in a search executed in a past; execute training of a first model that outputs a second search query including a virtual second named entity, which is different from the first named entity, based on the first search query; and execute data augmentation based on the second search query output by the trained first model.

Abstract: A method and apparatus for generating a virtual character, an electronic device and a computer readable storage medium are provided. The method includes: performing mesh simplification on an initial model of a virtual character to obtain a mesh-simplified model; obtaining a first target model by performing white model mapping rendering on an area of each material type on the mesh-simplified model, and obtaining a second target model by performing hyper-realistic rendering on the area of each material type on the mesh-simplified model; and establishing a bidirectional mapping between the first target model and the second target model, and obtaining a target virtual character through iterative updating of the bidirectional mapping.

Abstract: A method for training a three-dimensional face reconstruction model includes inputting an acquired sample face image into a three-dimensional face reconstruction model to obtain a coordinate transformation parameter and a face parameter of the sample face image; determining the three-dimensional stylized face image of the sample face image according to the face parameter of the sample face image and the acquired stylized face map of the sample face image; transforming the three-dimensional stylized face image of the sample face image into a camera coordinate system based on the coordinate transformation parameter, and rendering the transformed three-dimensional stylized face image to obtain a rendered map; and training the three-dimensional face reconstruction model according to the rendered map and the stylized face map of the sample face image.

Abstract: A display panel and a mobile terminal are provided. The display panel includes a flat area and a curved area. The display panel includes a panel body and a hard support layer that are stacked. The panel body includes a flat portion located in the flat area and a curved portion located in the curved area. The hard support layer includes a first bonding portion provided on one side of the flat portion and a second bonding portion provided on one side of the curved portion. A bending modulus of the second bonding portion is less than a bending modulus of the first bonding portion.

Abstract: A cascade circuit can include: N power conversion units connected in series between two ports of a power supply, where N is a positive integer greater than or equal to 2; a controller connected to one of the N power conversion units, and being configured to send a signal to be transmitted through the connected power conversion unit; where each of the power conversion units is configured to send the signal to be transmitted to a next-stage power conversion unit when the each of the power conversion unit shares a reference voltage with the adjacent next-stage power conversion unit; and where the signal to be transmitted is controlled to be transmitted from a previous-stage power conversion unit to a next-stage power conversion unit in sequence until the signal to be transmitted is received by all of the N power conversion units.

Abstract: An inductor current reconstruction circuit of a power converter can include: a switching current sampling circuit configured to acquire at least one of a current flowing through a main power transistor and a current flowing through a rectifier transistor to generate a switching current sampling signal; an inductor current generating circuit configured to generate a reconstruction signal representing an inductor current in one complete switching cycle; and where the reconstruction signal comprises the switching current sampling signal and a current analog signal generated according to the switching current sampling signal and an inductor voltage signal representing a voltage across an inductor in the power converter.

Abstract: Disclosed herein are systems and methods for collapsing sequencing reads and identifying similar sequencing reads. In one example, a method includes generating a plurality of first identifier subsequences from a first identifier sequence of each nucleotide sequencing read and generating a first signature for the nucleotide sequencing read by applying hashing to the plurality of first identifier subsequences. The method may include assigning the nucleotide sequencing read to a first particular bin of a first data structure based on the first signature and determining a nucleotide sequence for each first particular bin of the first data structure with one or more nucleotide sequencing reads assigned.

Abstract: Methods and systems are provided for determining a variant of interest by analyzing sizes and sequences of cfDNA fragments obtained from a test sample. The methods and systems provided herein implement processes that synergistically combine size and sequence information, thereby improving specificity and sensitivity of assays over conventional methods.

Abstract: A method and apparatus for information interaction, a device, and a storage medium are provided. The method for information interaction includes: selecting a first target effect based on an effect selection operation input by a first user for a target object, where the target object is associated with a preset theme; playing the first target effect in response to receiving a preset playing instruction for the target object; and in response to meeting a preset condition, showing interaction task information associated with the preset theme.

Abstract: A method and apparatus for controlling page display, a storage medium, and a mobile terminal are provided. The method for controlling page display includes: fixedly displaying a virtual viewing frame in a target page of a mobile terminal and showing a first page content of a preset virtual scene page in the virtual viewing frame, where the preset virtual scene page is associated with a preset theme, and associated information of the preset theme is shown outside the virtual viewing frame in the target page; and obtaining target motion data of the mobile terminal and transitioning from showing the first page content to showing a second page content based on the target motion data to realize sliding showing of the preset virtual scene page in the virtual viewing frame.

Abstract: The present disclosure provides a display control method and apparatus, an electronic device, and a storage medium. The present disclosure provides a display control method, including: determining a target control associated with a target trigger rule in response to at least one trigger rule being hit, where the target trigger rule is the hit trigger rule; and displaying the target control in an input box of a chat interface or an associated area of the input box, where the target control is configured to perform a corresponding function after being triggered.

Abstract: An interaction method of audio-video segmentation and apparatus, and a device and a storage medium. The method includes: detecting whether a selected clip exists in a target audio-video; in response to the selected clip existing in the target audio-video, displaying a split button upon detecting that a pointer on a track of the target audio-video is located in the selected clip; and splitting the selected clip, in response to a trigger operation for the split button, based on an intersection position of the pointer and the selected clip. Compared with an interaction means in which a split button resides in a pointer of a track, mis-operations of audio-video splitting can be reduced to the greatest extent, and the usage experience of a user is improved to a certain extent.

Abstract: A step-down circuit, an electronic device, and a step-down method are disclosed. The step-down circuit includes a positive input terminal and a negative input terminal for receiving an input voltage; and a positive output terminal and a negative output terminal for outputting a target voltage. The negative input terminal and the negative output terminal are grounded together. The step-down circuit also includes a switch circuit, a rectifier circuit, an isolation circuit, and a control unit for outputting control signals to control for turning on or off a switch in the switch circuit and for turning on or off a switch in the rectifier circuit, allowing the input voltage to sequentially pass through the switch in the switch circuit, a capacitor in the isolation circuit, and the switch in the rectifier circuit to obtain a target voltage.

Abstract: An antenna structure includes a main ground plane, a protruding ground plane, a feeding radiation element, a connection radiation element, a shorting radiation element, a first radiation element, and a second radiation element. The protruding ground plane is coupled to the main ground plane. The feeding radiation element has a feeding point. The connection radiation element is coupled to the feeding radiation element. The connection radiation element is further coupled through the shorting radiation element to the protruding ground plane. The first radiation element is coupled to the feeding radiation element. The second radiation element is coupled to the connection radiation element. The protruding ground plane further includes an extension portion. The first radiation element is adjacent to the extension portion of the protruding ground plane.

Abstract: Embodiments of the application provide a distress information sending method and system. By setting automatic switching of various communication means, a user may be rescued in time. The method includes a terminal device obtains first distress information, where the first distress information includes at least one of adverse sign information or positioning information of a user. The terminal device selects a first communication network from a plurality of communication networks in a preset sequence. When the terminal device can be connected to the rescue processing device by using the first communication network, the terminal device sends the first distress information to the rescue processing device by using the first communication network. Alternatively, when the terminal device cannot be connected to the rescue processing device by using the first communication network, the terminal device reselects a new first communication network from the plurality of communication networks in the preset sequence.