Patents by Inventor Chenfeng HE

Chenfeng HE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for detecting single T cell receptor affinity and sequence
    Patent number: 11162945
    Abstract: Provided herein are methods for determining the T cell receptor affinity and sequence of antigen-specific T cells using a micropipette adhesion assay and single cell paired TCR?/TCR? sequencing. Further provided are methods for the treatment of viral infections or cancers by adoptive transfer of high affinity functional T cells.
    Type: Grant
    Filed: April 6, 2017
    Date of Patent: November 2, 2021
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventors: Ning Jiang, Shuqi Zhang, Keyue Ma, Chenfeng He
  • DNA-BARCODED ANTIGEN MULTIMERS AND METHODS OF USE THEREOF
    Publication number: 20210139985
    Abstract: Provided herein are methods compositions and methods to generate pMHC libraries, and methods of using the pMHC libraries to determine the sequences of T cell receptors, and T cell developmental and activation status.
    Type: Application
    Filed: April 10, 2019
    Publication date: May 13, 2021
    Inventors: Ning JIANG, Shu-Qi ZHANG, Keyue MA, Chenfeng HE
  • HIGH-COVERAGE AND ULTRA-ACCURATE IMMUNE REPERTOIRE SEQUENCING USING MOLECULAR IDENTIFIERS
    Publication number: 20200131564
    Abstract: The present disclosure provides methods for the amplification and sequencing of the immune repertoire using barcoded oligonucleotides with molecular identifiers (MIDs). Further provided are methods for clustering-based data analysis of the sequencing reads to determine the immune repertoire.
    Type: Application
    Filed: July 9, 2018
    Publication date: April 30, 2020
    Inventors: Ning JIANG, Keyue MA, Ben S. WENDEL, Chenfeng HE, Mingjuan QU
  • METHODS AND COMPOSITIONS FOR DETECTING SINGLE T CELL RECEPTOR AFFINITY AND SEQUENCE
    Publication number: 20190094224
    Abstract: Provided herein are methods for determining the T cell receptor affinity and sequence of antigen-specific T cells using a micropipette adhesion assay and single cell paired TCR?/TCR? sequencing. Further provided are methods for the treatment of viral infections or cancers by adoptive transfer of high affinity functional T cells.
    Type: Application
    Filed: April 6, 2017
    Publication date: March 28, 2019
    Inventors: Ning JIANG, Shuqi ZHANG, Keyue MA, Chenfeng HE