Patents by Inventor Chenfeng Ke
Chenfeng Ke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250043083Abstract: Embodiments of the present disclosure pertain to a rotaxane composition that includes macrocyclic rings and polymers, where the polymers are covalently appended to one or more macrocycle-binding molecules, where each of the macrocyclic rings includes a cavity that is threaded onto the polymers, where some of the threaded macrocyclic rings are individually threaded onto two polymers to form double-threaded macrocyclic rings with a plurality of different segments, where each of the plurality of different segments includes a plurality of double-threaded macrocyclic rings, and where the plurality of different segments associate with one another to form a crystalline network. Additional embodiments of the present disclosure pertain to sensors that include such compositions, methods of manufacturing a three-dimensional structure by applying such compositions onto a surface, and methods of forming such compositions.Type: ApplicationFiled: August 2, 2024Publication date: February 6, 2025Applicant: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Miao Tang
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Publication number: 20240076415Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.Type: ApplicationFiled: October 30, 2023Publication date: March 7, 2024Applicant: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Qianming Lin
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Publication number: 20240002685Abstract: The invention provides a supramolecular polymer composition capable of co-assembly to maintain a three dimensional (3-D) macrostructural form after 3-D printing, made of a solvent, a template molecule; and a reactive component. The reactive component can be at least one monomer that is capable of hydrogen bonding with the template molecule to form a 1D supramolecular structure. The template may be an amphiphilic polymer. The monomer has at least two pendant groups capable of covalent crosslinking. The invention also includes a 3-D structure formed by crosslinking a 3-D printed supramolecular polymer composition, which optionally has a mesoporous structure. Also included is a method of manufacturing a 3-D structure by delivering a supramolecular polymer composition onto a surface of a substrate to form the 3-D structure.Type: ApplicationFiled: September 19, 2023Publication date: January 4, 2024Applicant: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Pengfei Zhang, Longyu Li, Qianming Lin
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Patent number: 11845812Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.Type: GrantFiled: February 12, 2021Date of Patent: December 19, 2023Assignee: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Qianming Lin
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Patent number: 11814527Abstract: The invention provides a supramolecular polymer composition capable of co-assembly to maintain a three dimensional (3-D) macrostructural form after 3-D printing, made of a solvent, a template molecule; and a reactive component. The reactive component can be at least one monomer that is capable of hydrogen bonding with the template molecule to form a 1D supramolecular structure. The template may be an amphiphilic polymer. The monomer has at least two pendant groups capable of covalent crosslinking. The invention also includes a 3-D structure formed by crosslinking a 3-D printed supramolecular polymer composition, which optionally has a mesoporous structure. Also included is a method of manufacturing a 3-D structure by delivering a supramolecular polymer composition onto a surface of a substrate to form the 3-D structure.Type: GrantFiled: April 27, 2018Date of Patent: November 14, 2023Assignee: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Pengfei Zhang, Longyu Li, Qianming Lin
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Publication number: 20230174680Abstract: Embodiments of the present disclosure pertain to a composition that includes a rotaxane. The rotaxane includes a plurality of macrocyclic rings and a polymer with a molecular weight below 10,000 Da that is covalently appended to one or more sterically hindered molecules. The cavities of the macrocyclic rings are threaded onto the polymer. The plurality of threaded macrocyclic rings include a plurality of different segments that each include a plurality of threaded macrocyclic rings. Each of the plurality of different segments is in the form of a crystalline network. Further embodiments of the present disclosure pertain to methods of forming the rotaxanes by covalently appending one or more sterically hindered molecules onto a polymer and threading a plurality of macrocyclic rings onto the polymer. Additional embodiments of the present disclosure pertain to methods of manufacturing a three-dimensional structure by applying a composition of the present disclosure onto a surface.Type: ApplicationFiled: May 10, 2021Publication date: June 8, 2023Applicant: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Qianming Lin, Longyu li, Miao Tang
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Patent number: 11267979Abstract: Fluorescent dyes, ink compositions comprising the dyes, methods and devices for printing the ink compositions, images printed using the ink compositions and methods for authenticating the printed images are provided. The fluorescent dyes are heterorotaxanes that include large macrocyclic rings around fluorophores and are capable of emitting solid-state fluorescence. When the heterorotaxanes are combined with encapsulating agents and competitive binding agents in aqueous solution, the resulting ink composition exhibits a complex, dynamic equilibrium that provides a tunable fluorescence emission spectrum with a non-linear response to the dye concentration.Type: GrantFiled: February 6, 2019Date of Patent: March 8, 2022Assignees: Northwestern University, Innotune LLCInventors: James Fraser Stoddart, Xisen Hou, Chenfeng Ke, Roger B. Pettman
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Publication number: 20210171668Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.Type: ApplicationFiled: February 12, 2021Publication date: June 10, 2021Applicant: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Qianming Lin
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Patent number: 10954315Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.Type: GrantFiled: November 15, 2017Date of Patent: March 23, 2021Assignee: TRUSTEES OF DARTMOUTH COLLEGEInventors: Chenfeng Ke, Qianming Lin
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Publication number: 20200131383Abstract: The invention provides a supramolecular polymer composition capable of co-assembly to maintain a three dimensional (3-D) macrostructural form after 3-D printing, made of a solvent, a template molecule; and a reactive component. The reactive component can be at least one monomer that is capable of hydrogen bonding with the template molecule to form a 1D supramolecular structure. The template may be an amphiphilic polymer. The monomer has at least two pendant groups capable of covalent crosslinking. The invention also includes a 3-D structure formed by crosslinking a 3-D printed supramolecular polymer composition, which optionally has a mesoporous structure. Also included is a method of manufacturing a 3-D structure by delivering a supramolecular polymer composition onto a surface of a substrate to form the 3-D structure.Type: ApplicationFiled: April 27, 2018Publication date: April 30, 2020Applicant: Trustees of Dartmouth CollegeInventors: Chenfeng Ke, Pengfei Zhang, Longyu Li, Qianming Lin
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Publication number: 20190169456Abstract: Fluorescent dyes, ink compositions comprising the dyes, methods and devices for printing the ink compositions, images printed using the ink compositions and methods for authenticating the printed images are provided. The fluorescent dyes are heterorotaxanes that include large macrocyclic rings around fluorophores and are capable of emitting solid-state fluorescence. When the heterorotaxanes are combined with encapsulating agents and competitive binding agents in aqueous solution, the resulting ink composition exhibits a complex, dynamic equilibrium that provides a tunable fluorescence emission spectrum with a non-linear response to the dye concentration.Type: ApplicationFiled: February 6, 2019Publication date: June 6, 2019Applicants: Northwestern University, Innotune LLCInventors: James Fraser Stoddart, Xisen Hou, Chenfeng Ke, Roger B. Pettman
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Publication number: 20190144569Abstract: Provided are supramolecular polypseudorotaxane hydrogel compositions and 3-D structures capable of reversible 3-D structural deformation which include (a) a solvent; (b) an at least partially linear polymer, where the polymer further comprises groups capable of covalent crosslinking between the polymers; (ii) at least one first macrocyclic ring which forms a pseudorotaxane with a polymer in the polymer network; and (iii) at least one second macrocyclic ring that does not form the pseudorotaxane. The hydrogel composition has a viscosity which allows for 3-D printing of the hydrogel to form a 3-D structure, and a storage (elastic) modulus after crosslinking that allows for the 3-D structure to undergo reversible 3-D structural deformation upon change of solvent conditions. Also provided are methods of manufacturing the compositions and 3-D structures.Type: ApplicationFiled: November 15, 2017Publication date: May 16, 2019Inventors: Chenfeng Ke, Qianming Lin
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Patent number: 9937272Abstract: A water-soluble compound of the formula (I): wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.Type: GrantFiled: February 28, 2017Date of Patent: April 10, 2018Assignee: University of BristolInventors: Chenfeng Ke, Anthony P. Davis
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Publication number: 20170266321Abstract: A water-soluble compound of the formula (I): wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.Type: ApplicationFiled: February 28, 2017Publication date: September 21, 2017Applicant: University of BristolInventors: Chenfeng KE, Anthony P. Davis
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Patent number: 9610365Abstract: A water-soluble compound of the formula (I): wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.Type: GrantFiled: April 26, 2013Date of Patent: April 4, 2017Assignee: University of BristolInventors: Chenfeng Ke, Anthony P. Davis
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Publication number: 20160137864Abstract: Fluorescent dyes, ink compositions comprising the dyes, methods and devices for printing the ink compositions, images printed using the ink compositions and methods for authenticating the printed images are provided. The fluorescent dyes are heterorotaxanes that include large macrocyclic rings around fluorophores and are capable of emitting solid-state fluorescence. When the heterorotaxanes are combined with encapsulating agents and competitive binding agents in aqueous solution, the resulting ink composition exhibits a complex, dynamic equilibrium that provides a tunable fluorescence emission spectrum with a non-linear response to the dye concentration.Type: ApplicationFiled: September 28, 2015Publication date: May 19, 2016Inventors: J. Fraser Stoddart, Xisen Hou, Chenfeng Ke, Roger B. Pettman
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Publication number: 20160137845Abstract: Fluorescent dyes are provided. The fluorescent dyes are heterorotaxanes that include large macrocyclic rings around fluorophores and are capable of emitting solid-state fluorescence.Type: ApplicationFiled: September 28, 2015Publication date: May 19, 2016Inventors: J. Fraser Stoddart, Xisen Hou, Chenfeng Ke
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Publication number: 20150147275Abstract: A water-soluble compound of the formula (I): (Formula (I)) wherein R9 and R10 are suitably hydrophilic substituents, which may be used to selectively bind to a target saccharide such as glucose and which exhibits a detectable spectroscopic response to such binding, thus enabling its use in the detection and correction of blood glucose concentrations in vivo.Type: ApplicationFiled: April 26, 2013Publication date: May 28, 2015Inventors: Chenfeng Ke, Anthony P. Davis