Abstract: A wrench has a wrench body, a control member, a braking toothed member and a ratchet wheel. The wrench body has a first and a second operating portions. The first operating portion has an assembling aperture and a control aperture, a control member having a handle and a shaft rod, the shaft rod provided with a stepped through hole and disposed in the control aperture; a braking toothed member disposed in the arcuate groove, an end of the braking toothed member has a toothed portion and a convex groove, the convex groove connected to a link shaft via a connecting pin, the link shaft jacketed by an elastic member and together disposed in the through hole. The ratchet wheel disposed in the assembling aperture, an annular toothed portion disposed on a periphery of the ratchet wheel and engaging with the toothed portion of the braking toothed member.

Abstract: An adaptive charging system comprises at least one solar panel and a voltage regulator. The solar panel comprises a protective layer, a first EVA layer, a plurality of solar cells, a plurality of connectors, a second EVA layer and a first supporting layer. The plurality of solar cells are interconnected by the connectors, forming a main body layer. The protective layer, the first EVA layer, the main body layer, the second EVA layer and the first supporting layer are bonded together from top to bottom. The voltage regulator comprises a sampling logic power supply circuit, a microcontroller (MCU) logic circuit, a DC-DC charging circuit, a sampling current conditioning circuit, and a charging matching circuit. When the charging system charges Apple® devices, an automatic reset control logic can be implemented. The system detects the amount of light is changing based on the sampled voltage and the analog voltage signal, and monitors the detection for an additional duration of time.

Abstract: A wrench has a wrench body, a control member, a braking toothed member and a ratchet wheel. The wrench body has a first and a second operating portions. The first operating portion has an assembling aperture and a control aperture, a control member having a handle and a shaft rod, the shaft rod provided with a stepped through hole and disposed in the control aperture; a braking toothed member disposed in the arcuate groove, an end of the braking toothed member has a toothed portion and a convex groove, the convex groove connected to a link shaft via a connecting pin, the link shaft jacketed by an elastic member and together disposed in the through hole. The ratchet wheel disposed in the assembling aperture, an annular toothed portion disposed on a periphery of the ratchet wheel and engaging with the toothed portion of the braking toothed member.

Abstract: An adaptive charging system comprises at least one solar panel and a voltage regulator. The solar panel comprises a protective layer, a first EVA layer, a plurality of solar cells, a plurality of connectors, a second EVA layer and a first supporting layer. The plurality of solar cells are interconnected by the connectors, forming a main body layer. The protective layer, the first EVA layer, the main body layer, the second EVA layer and the first supporting layer are bonded together from top to bottom. The voltage regulator comprises a sampling logic power supply circuit, a microcontroller (MCU) logic circuit, a DC-DC charging circuit, a sampling current conditioning circuit, and a charging matching circuit. When the charging system charges Apple® devices, an automatic reset control logic can be implemented. The system detects the amount of light is changing based on the sampled voltage and the analog voltage signal, and monitors the detection for an additional duration of time.

Abstract: An adaptive charging system comprises at least one solar panel and a voltage regulator. The solar panel comprises a protective layer, a first EVA layer, a plurality of solar cells, a plurality of connectors, a second EVA layer and a first supporting layer. The plurality of solar cells are interconnected by the connectors, forming a main body layer. The protective layer, the first EVA layer, the main body layer, the second EVA layer and the first supporting layer are bonded together from top to bottom. The voltage regulator comprises a sampling logic power supply circuit, a microcontroller (MCU) logic circuit, a DC-DC charging circuit, a sampling current conditioning circuit, and a charging matching circuit. When the charging system charges Apple® devices, an automatic reset control logic can be implemented. The system detects the amount of light is changing based on the sampled voltage and the analog voltage signal, and monitors the detection for an additional duration of time.

Abstract: A targeted vector allowing enhanced gene transfer to human hepato-cellular carcinoma (HCC1) cells in vitro was developed using cationic liposomes covalently conjugated with the mAb AF-20. This high affinity antibody recognizes a rapidly internalized 180 kDa cell surface glycoprotein which is abundantly expressed on the surface of human HCC and other cancer cells. Quantitative binding analysis of liposomes with target cells by flow cytometry showed specific association of mAb-targeted liposomes with human HCC cells. Using mAb-targeted cationic liposomes containing 20% DOTAP, in the presence or absence of serum, gene expression in HuH-7 cells was enhanced up to 40-fold as compared to liposomes conjugated with an isotype-matched non-relevant control antibody. Transfection specificity was not observed in a control cell line that does not express the antigen recognized by mAb AF-20.

Abstract: Nucleic acid-immunoliposome compositions useful as therapeutic agents are disclosed. These compositions preferably comprise (i) cationic liposomes, (ii) a single chain antibody fragment which binds to a transferrin receptor, and (iii) a nucleic acid encoding a wild type p53. These compositions target cells which express transferrin receptors, e.g., cancer cells. These compositions can be used therapeutically to treat persons or animals who have cancer, e.g., head and neck cancer, breast cancer or prostate cancer.

Abstract: Nucleic acid-immunoliposome compositions useful as therapeutic agents are disclosed. These compositions preferably comprise (i) cationic liposomes, (ii) a single chain antibody fragment which binds to a transferrin receptor, and (iii) a nucleic acid encoding a wild type p53. These compositions target cells which express transferrin receptors, e.g., cancer cells. These compositions can be used therapeutically to treat persons or animals who have cancer, e.g., head and neck cancer, breast cancer or prostate cancer.

Abstract: A targeted vector allowing enhanced gene transfer to human hepato-cellular carcinoma (HCC1) cells in vitro was developed using cationic liposomes covalently conjugated with the mAb AF-20. This high affinity antibody recognizes a rapidly internalized 180 kDa cell surface glycoprotein which is abundantly expressed on the surface of human HCC and other cancer cells. Quantitative binding analysis of liposomes with target cells by flow cytometry showed specific association of mAb-targeted liposomes with human HCC cells. Using mAb-targeted cationic liposomes containing 20% DOTAP, in the presence or absence of serum, gene expression in HuH-7 cells was enhanced up to 40-fold as compared to liposomes conjugated with an isotype-matched non-relevant control antibody. Transfection specificity was not observed in a control cell line that does not express the antigen recognized by mAb AF-20.