Abstract: A device includes a fin extending from a semiconductor substrate; a gate stack over the fin; a first spacer on a sidewall of the gate stack; a source/drain region in the fin adjacent the first spacer; an inter-layer dielectric layer (ILD) extending over the gate stack, the first spacer, and the source/drain region, the ILD having a first portion and a second portion, wherein the second portion of the ILD is closer to the gate stack than the first portion of the ILD; a contact plug extending through the ILD and contacting the source/drain region; a second spacer on a sidewall of the contact plug; and an air gap between the first spacer and the second spacer, wherein the first portion of the ILD extends across the air gap and physically contacts the second spacer, wherein the first portion of the ILD seals the air gap.

Abstract: A semiconductor package including a ring structure with one or more indents and a method of forming are provided. The semiconductor package may include a substrate, a first package component bonded to the substrate, wherein the first package component may include a first semiconductor die, a ring structure attached to the substrate, wherein the ring structure may encircle the first package component in a top view, and a lid structure attached to the ring structure. The ring structure may include a first segment, extending along a first edge of the substrate, and a second segment, extending along a second edge of the substrate. The first segment and the second segment may meet at a first corner of the ring structure, and a first indent of the ring structure may be disposed at the first corner of the ring structure.

Abstract: A remanufacturing method of a drill includes providing a drill with a worn-out area. The drill comprises: a shank part; and a flute part arranged on one end of the shank part. A chisel edge is formed on the front end of the flute part, and the radius of any one of the cross section of the chisel edge is defined as a core thickness; a first blade and a second blade with tilt directions toward the shank part are formed on the two sides of the chisel edge. The first circumferential surface of the first blade and the second circumferential surface of the second blade are respectively extended and spiraled toward the shank part along a periphery of the flute part and form two helical cutting edges, a first debris-discharging groove and a second debris-discharging groove. The first blade comprises a first cutting edge. The first cutting edge and the first circumferential surface define the worn-out area.

Abstract: A brain tumor types distinguish system includes an image outputting device and a server computing device. The image outputting device outputs at least three brain images captured from the position of a brain tumor. The server computing device pre-stores a plurality of distinguish pathways corresponding to different types of brain tumors. The server computing device includes an image receiving module, an image pre-processing module, a data comparison module and a distinguish module. The image receiving module receives the brain images. The image pre-processing module pre-processes the brain images to obtain corresponding processed images thereof. The data comparison module compares the brain images and the processed images with the distinguish pathways to obtain at least three comparison results. The distinguish module statistically analyzes the comparison results to obtain a distinguish result.

Abstract: A remanufacturing method of a drill includes providing a drill with a worn-out area. The drill comprises: a shank part; and a flute part arranged on one end of the shank part. A chisel edge is formed on the front end of the flute part, and the radius of any one of the cross section of the chisel edge is defined as a core thickness; a first blade and a second blade with tilt directions toward the shank part are formed on the two sides of the chisel edge. The first circumferential surface of the first blade and the second circumferential surface of the second blade are respectively extended and spiraled toward the shank part along a periphery of the flute part and form two helical cutting edges, a first debris-discharging groove and a second debris-discharging groove. The first blade comprises a first cutting edge. The first cutting edge and the first circumferential surface define the worn-out area.

Abstract: A benign tumor development trend assessment system includes an image outputting device and a server computing device. The image outputting device outputs first/second images captured from the same position in a benign tumor. The server computing device includes an image receiving module, an image pre-processing module, a target extracting module, a feature extracting module and a trend analyzing module. The image receiving module receives the first/second images. The image pre-processing module pre-processes the first/second images to obtain first/second local images. The target extracting module automatically detects and delineates tumor regions from the first/second local images to obtain first/second region of interest (ROI) images. The feature extracting module automatically identifies the first/second ROI images to obtain at least one first/second features. The trend analyzing module analyzes the first/second features to obtain a tumor development trend result.

Abstract: A method for enhancing an accuracy of a benign tumor development trend assessment system includes: a first processing procedure, an image captured before the treatment is inputted to and be processed by a server computing device of the benign tumor development trend assessment system to obtain a first processing result; a second processing procedure, the images captured before and in at least one period after the treatment are inputted to and processed by the server computing device to obtain a second processing result; a trend analyzing procedure, the trend analyzing module of the server computing device analyzes the first processing result, the second processing result and the trend pathways to obtain a tumor development trend result; and a storing procedure, the first processing result, the second processing result and the tumor development trend result are transformed to an individual trend pathway which is stored in the trend analyzing module.

Abstract: A tumor recurrence prediction device is provided, which includes a data extraction circuit, a memory, and a processor. The data extraction circuit extracts multiple patient clinical data and multiple slice image information; a memory stores multiple instructions; a processor is connected to the data extraction circuit and the memory, and is configured to load and execute the multiple instructions to: receive the multiple patient clinical data and the multiple slice image information; generate clinical feature information and tumor image feature information according to the multiple patient clinical data and the multiple slice image information; train a prediction model according to the clinical feature information and the tumor image feature information; and predict tumor recurrence for patient information of a patient using the prediction model. In addition, a tumor recurrence prediction method is also disclosed here.

Abstract: A method for localizing an intracranial electrode in a subject's brain is provided. The intracranial electrode has at least one electrode contact. The method includes: acquiring a first brain image reconstructed from first image data acquired after electrode-implantation; acquiring a second brain image reconstructed from second image data acquired before the electrode-implantation; co-registering the first brain image and the second brain image to acquire spatial transformation parameters; extracting a first coordinate of the electrode contact from the first brain image; converting the first coordinate into a second coordinate in the second brain image by using the spatial transformation parameters; co-registering the second brain image and a universal brain atlas to define functional zones in the second brain image; and defining a corresponding functional zone where the second coordinate is located. Another alternative method and a system for localizing an intracranial electrode are also provided herein.

Abstract: The present disclosure provides an operating method of an automatic analysis system on magnetic resonance imaging (MRI), which includes steps as follows. Images are received from of the subject's brain from the MRI machine. Contrast-enhanced T1-weighted images and T2-weighted images are obtained from the images, and the pre-processing is performed on the images. The ratio of T2-weighted images to contrast-enhanced T1-weighted images is calculated to generate contrast-enhanced images. The unsupervised clustering is performed on the region of interest in the contrast-enhanced image to separate a cystic part and a non-cystic part so as to calculate the feature parameters. After radiosurgery is performed on the brain tumor corresponding to the region of interest, the volume change of the tumor is analyzed. The linear regression analysis of the feature parameters and the volume change of the tumor is performed for prognostic evaluation.

Abstract: A system for analyzing brain tissue components based on magnetic resonance image. The system includes a memory and a processor. The memory stores instructions. The processor accesses and executes the instructions to perform the following: extracting maps of tissue from a brain magnetic resonance imaging (MRI) corresponding to normal subjects; averaging the maps of tissue according to a number of the normal subjects to generate reference maps that correspond to different tissues; receiving a brain MRI sample having a targeted region; and analyzing the brain MRI sample based on the reference maps and the targeted region to generate an analysis result, in which the analysis result indicates a ratio of tissues in the targeted region of the brain MRI sample.

Abstract: A method for localizing an intracranial electrode in a subject's brain is provided. The intracranial electrode has at least one electrode contact. The method includes: acquiring a first brain image reconstructed from first image data acquired after electrode-implantation; acquiring a second brain image reconstructed from second image data acquired before the electrode-implantation; co-registering the first brain image and the second brain image to acquire spatial transformation parameters; extracting a first coordinate of the electrode contact from the first brain image; converting the first coordinate into a second coordinate in the second brain image by using the spatial transformation parameters; co-registering the second brain image and a universal brain atlas to define functional zones in the second brain image; and defining a corresponding functional zone where the second coordinate is located. Another alternative method and a system for localizing an intracranial electrode are also provided herein.

Abstract: A benign tumor development trend assessment system includes an image outputting device and a server computing device. The image outputting device outputs first/second images captured from the same position in a benign tumor. The server computing device includes an image receiving module, an image pre-processing module, a target extracting module, a feature extracting module and a trend analyzing module. The image receiving module receives the first/second images. The image pre-processing module pre-processes the first/second images to obtain first/second local images. The target extracting module automatically detects and delineates tumor regions from the first/second local images to obtain first/second region of interest (ROI) images. The feature extracting module automatically identifies the first/second ROI images to obtain at least one first/second features. The trend analyzing module analyzes the first/second features to obtain a tumor development trend result.

Abstract: A method for localizing an intracranial electrode in a subject's brain is provided. The intracranial electrode has at least one electrode contact. The method includes: acquiring a first brain image reconstructed from first image data acquired after electrode-implantation; acquiring a second brain image reconstructed from second image data acquired before the electrode-implantation; co-registering the first brain image and the second brain image to acquire spatial transformation parameters; extracting a first coordinate of the electrode contact from the first brain image; converting the first coordinate into a second coordinate in the second brain image by using the spatial transformation parameters; co-registering the second brain image and a universal brain atlas to define functional zones in the second brain image; and defining a corresponding functional zone where the second coordinate is located. Another alternative method and a system for localizing an intracranial electrode are also provided herein.

Abstract: A system for analyzing brain tissue components based on magnetic resonance image. The system includes a memory and a processor. The memory stores instructions. The processor accesses and executes the instructions to perform the following: extracting maps of tissue from a brain magnetic resonance imaging (MRI) corresponding to normal subjects; averaging the maps of tissue according to a number of the normal subjects to generate reference maps that correspond to different tissues; receiving a brain MRI sample having a targeted region; and analyzing the brain MRI sample based on the reference maps and the targeted region to generate an analysis result, in which the analysis result indicates a ratio of tissues in the targeted region of the brain MRI sample.

Abstract: A drill structure comprises a shank part and a bit part. A web is formed on the front end of the bit part. Two sides of the web are tilted backward to form two cutting faces. At least one chip-discharge groove is formed on the surface of the bit part. Each cutting face includes a primary cutting face and a secondary cutting face. The thickness of the prismatic web edge of at least one primary cutting face is smaller than the outer-side width of the primary cutting face. An auxiliary cutting face is extended to the wall of the flute from the cutting edge of the primary cutting face and a portion of a blade back of the secondary cutting face of another cutting face. The present invention decreases the drilling resistance during drilling a hole and increases the service life of the drill bit.

Abstract: A method for localizing an intracranial electrode in a subject's brain is provided. The intracranial electrode has at least one electrode contact. The method includes: acquiring a first brain image reconstructed from first image data acquired after electrode-implantation; acquiring a second brain image reconstructed from second image data acquired before the electrode-implantation; co-registering the first brain image and the second brain image to acquire spatial transformation parameters; extracting a first coordinate of the electrode contact from the first brain image; converting the first coordinate into a second coordinate in the second brain image by using the spatial transformation parameters; co-registering the second brain image and a universal brain atlas to define functional zones in the second brain image; and defining a corresponding functional zone where the second coordinate is located. Another alternative method and a system for localizing an intracranial electrode are also provided herein.

Abstract: A drill structure comprises a shank part and a bit part. A web is formed on the front end of the bit part. Two sides of the web are tilted backward to form two cutting faces. At least one flute (chip-discharge groove) is formed on the surface of the bit part. Each cutting face includes a primary cutting face and a secondary cutting face. The thickness of the prismatic web edge of at least one primary cutting face is smaller than the outer-side width of the primary cutting face. An auxiliary cutting face is extended to the wall of the flute from the cutting edge of the primary cutting face and a portion of a blade back of the secondary cutting face of another cutting face. The present invention decreases the drilling resistance during drilling a hole and increases the service life of the drill bit.

Abstract: The present disclosure provides a magnetic resonance (MR) image analysis method for a patient who underwent radiotherapy. The method includes the steps: receiving an MR image set of a patient and a dose map of a radiotherapy plan; converting the dose intensity distribution of the dose map into the relative spatial positions in the MR image set; selecting a radiation dose and a radiation exposure region, wherein the radiation exposure region has radiation intensity being equal to or higher than the radiation dose; using the radiation exposure region to determine a region of interest (ROI) in the MR image set; classifying the voxels inside the ROI of the MR image set into different clusters according to the grayscale values of the voxels inside the ROI; and calculating the volume or ratios of the different clusters inside the ROI. The present disclosure also provides a method for evaluating risks of radiotherapy.

Abstract: A drill structure comprises a shank part and a flute part disposed on one end of the shank part. The front region of the flute part has a web. Two sides of the web are tilted backward to form a first cutting face and a second cutting face. At least one flute is formed on the outer surface of the flute part. The flute part has a bit core in the center thereof. The radius of the cross section of the bit core is defined as the web thickness. The first cutting face includes a first primary cutting face and a first secondary cutting face. The second cutting face includes a second primary cutting face and a second secondary cutting face. The first cutting edge of the first primary cutting face is not parallel with the first connection edge. The width of the primary cutting face width is larger than the web thickness. The drill structure has high cutting ability and long service life.