Patents by Inventor CHENG-CHOU YU

CHENG-CHOU YU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210139592
    Abstract: An anti-PD-L1 antibody, or an antigen-binding fragment thereof, comprising: a heavy chain variable region comprising the three CDRs with the sequences of SEQ ID NOs: 2-4, 6-8, 10-12, 14-16, or 18-20; and/or a light chain variable region comprising the three CDRs with the sequences of SEQ ID NOs: 22-24, 26-28, 30-32, 34-36, or 38-40, wherein the antibody is a chimeric, humanized, composite, or human antibody.
    Type: Application
    Filed: July 14, 2019
    Publication date: May 13, 2021
    Applicant: Development Center for Biotechnology
    Inventors: Cheng-Chou YU, Shih-Rang YANG, Tsung-Han HSIEH, Mei-Chi CHAN, Shu-Ping YEH, Chuan-Lung HSU, Ling-Yueh HU, Chih-Lun HSIAO
  • Patent number: 10138300
    Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
    Type: Grant
    Filed: July 3, 2017
    Date of Patent: November 27, 2018
    Assignee: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: Jiann-Shiun Lai, Li-Shuang Ai, Yan-Da Lai, Yen-Yu Wu, Yi-San Tsai, Yi-Jiue Tsai, Juo-Yu Huang, Cheng-Chou Yu, Chuan-Lung Hsu, Chien-Tsun Kuan, Szu-Liang Lai, Li-Ya Wang
  • Publication number: 20180186884
    Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
    Type: Application
    Filed: July 3, 2017
    Publication date: July 5, 2018
    Inventors: JIANN-SHIUN LAI, Li-Shuang Ai, Yan-Da Lai, Yen-Yu Wu, Yi-San Tsai, Yi-Jiue Tsai, Juo-Yu Huang, Cheng-Chou Yu, Chuan-Lung Hsu, Chien-Tsun Kuan, Szu-Liang Lai, Li-Ya Wang
  • Publication number: 20170369525
    Abstract: A method for specific linkage to a glycoprotein includes obtaining a glycoprotein having a monoglycan or diglycan attached thereto; producing a reactive functional group on a sugar unit on the glycoprotein; and coupling a linker or a payload to the reactive functional group on the glycoprotein.
    Type: Application
    Filed: December 31, 2015
    Publication date: December 28, 2017
    Applicants: Development Center for Biotechnology, DCB-USA LLC
    Inventors: Chao-Pin Lee, Cheng-Chou Yu, Chi-Huey Wong, Chuan-Lung Hsu, Chun-Chung Lee, Shih-Hsien Chuang, Ta-Tung Yuan, Yi-Jen Chen, Yu-Chin Nieh
  • Publication number: 20170233480
    Abstract: The present invention relates to an antibody or antigen-binding fragment thereof that bind human vascular endothelial growth factor receptor 2 (VEGFR-2). The present invention also relates to a method for inhibiting VEGFR-2-mediated signaling in a subject in need, a method for treating diseases and/or disorders caused by or related to VEGFR-2 activity and/or signaling in a subject afflicted with the diseases and disorders, a method for treating tumor in a subject afflicted with the tumor, a method for inhibiting cell proliferation of endothelial cells in a subject in need, and a method for detecting human vascular endothelial growth factor receptor in a sample.
    Type: Application
    Filed: December 29, 2016
    Publication date: August 17, 2017
    Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY
    Inventors: JIANN-SHIUN LAI, LI-SHUANG AI, YAN-DA LAI, YEN-YU WU, YI-SAN TSAI, YI-JIUE TSAI, JUO-YU HUANG, CHENG-CHOU YU, CHUAN-LUNG HSU, CHIEN-TSUN KUAN, SZU-LIANG LAI, LI-YA WANG