Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: The invention relates to a processing device (1) for processing of liquid sample contained in a multiwell carrier (2), wherein the processing device comprises a housing (3) with a bottom part (4) and a lid part (5), wherein the bottom part and the lid part delimit an inner space of the housing, and a connection part (6) for fluidically connecting the processing device to a processing unit (7) wherein the connection part is fluidically connected to the inner space, wherein the housing has several hollow extension tubes (9a, 9b), which extend from the bottom part and which are fluidically connected to the inner space.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: A semiconductor device and a method of fabricating the semiconductor device are disclosed. The method includes forming a fin base on a substrate, epitaxially growing a S/D region on the fin base, forming a contact opening on the S/D region, forming a semiconductor nitride layer on a sidewall of the contact opening, performing a densification process on the semiconductor nitride layer to form a densified semiconductor nitride layer, forming a silicide layer on an exposed surface of the S/D region in the contact opening, forming a contact plug in the contact opening, and forming a via structure in the contact plug.

Abstract: The invention relates to an image acquisition system (1) for acquiring an image of a liquid sample (2), comprising a well (3) that stores liquid sample (2), an image acquisition device (4) for acquiring an image of the liquid sample (2) in the well (3), a lid device (5) for covering the well (3) wherein the lid device (5) comprises a lid (6) having a lid part (7) and a lid extension (8) that extends from the lid part (7) into the well (3). The image acquisition system is characterized in that at least one part of the lid extension (8) is in physical contact with the liquid sample (2) when an image is acquired by means of the image acquisition device (4) and a light beam passes through the part of the lid extension (8) that is in physical contact with the liquid sample (2) before it is received by the image acquisition device (4).

Abstract: A charging method includes detecting a system power, confirming that a hybrid power operation is executed when the system power is not less than a preset power and a hybrid power mechanism is turned on, forcibly disabling a timing operation when the hybrid power operation is executed, confirming that a charging operation is executed when the system power is less than the preset power and the hybrid power mechanism is turned on, starting the timing operation to accumulate a charging time when starting to execute the charging operation, and forcibly stopping the charging operation when the charging time is longer than a preset time.

Abstract: An electronic device with hybrid power source includes a system circuit, a charging and discharging circuit, a power connector, two batteries, and a controller. The charging and discharging circuit is connected to the system circuit, the power connector, and the two batteries. The controller is connected to the processor and the charging and discharging circuit, and the controller has a hybrid power supply mode. The controller detects the operating power of the processor in the system circuit, and controls the power mode from a single power mode to a hybrid power supply mode in response to that the operating power reaches or exceeds the power threshold. In the hybrid power supply mode, under control of the controller, the processor releases a power limit, and the charging and discharging circuit powers the system circuit by using both the battery with greater energy level and an external power.

Abstract: An electrical power conversion device, a function triggering circuit for the electrical power conversion device, and a function triggering method for the electrical power conversion device are provided. The function triggering circuit is coupled between the secondary side of the transformer and the control module and includes a current detection circuit, a delay circuit and a switching circuit. The current detection circuit senses the secondary side of the transformer to generate a detection signal of delay. Before steady-state duty of the transformer, the delay circuit causes an initial level to be higher than an internal level. After steady-state duty of the transformer, the switching circuit selectively generates a function triggering signal according to the detection signal. The function triggering signal is for triggering the control module to carry out an overcurrent protection operation.

Abstract: The invention relates to a processing device for processing a liquid sample, the processing device comprising at least one condenser element for condensing of vaporized liquid of the liquid sample and a housing that is positionable such that the condenser element is in fluid connection with a receptacle having the liquid sample, wherein the condenser element is part of the housing and/or arrangeable or arranged in a space of the housing, and at least one temperature changing device for creating a temperature difference between the condenser element and the vaporized liquid of the liquid sample.

Abstract: A single image deraining method is proposed. A wavelet transforming step processes an initial rain image to generate an i-th stage low-frequency rain image and a plurality of i-th stage high-frequency rain images. An image deraining step inputs the i-th stage low-frequency rain image to a low-frequency deraining model to output an i-th stage low-frequency derain image. A first inverse wavelet transforming step recombines the n-th stage low-frequency derain image with the n-th stage high-frequency derain images to form an n-th stage derain image. A weighted blending step blends a (n?1)-th stage low-frequency derain image with the n-th stage derain image to generate a (n?1)-th stage blended derain image. A second inverse wavelet transforming step recombines the (n?1)-th stage high-frequency derain images with the (n?1)-th stage blended derain image to form a (n?1)-th stage derain image, and sets n to n?1 and repeats the last two steps.

Abstract: A visual recognition based method for projecting patterned light includes: projecting a calibration image onto a projection screen by a projection module; capturing the calibration image by an image-capturing module to obtain a calibration information between the projection module and the image-capturing module; capturing an object by the image-capturing module to obtain a to-be-recognized image of the object; detecting the object in the to-be-recognized image and acquiring a plurality of feature points associated with a plurality of feature areas of the object in the to-be-recognized image; retrieving a plurality of target feature points corresponding to a target object from the feature points; obtaining a projection coordinate of the target feature points\ according to the calibration information and providing the projection coordinate to the projection module; and projecting a projection pattern with shape corresponding to the target object onto the object by the projection module according to the projecti

Abstract: An automatic fluid replacement device is adapted to be mounted on an opening of a storage barrel. The automatic fluid replacement device includes a robotic arm, at least one fluid convey joint and a controller. The robotic arm has a gripper. The fluid convey joint includes a convey pipe, a sleeve and a sealing bag. The convey pipe is configured to deliver a fluid. The sleeve is sleeved on the convey pipe. The gripper clamps the sleeve. The sealing bag is sleeved on the sleeve. The controller is configured for automatically controlling the robotic arm to move the fluid convey joint into the opening and controlling the sealing bag to be inflated to seal the opening.

Abstract: In one example, a keyboard housing may include a chassis, a plurality of keys exposed through a top surface of the chassis, and an input device assembly connected to the chassis. The input device assembly may include a flexible touch sensing component to receive a touch input and a support structure. The support structure may include a first portion and a second portion foldable onto the first portion. The first portion and the second portion may support the flexible touch sensing component.

Abstract: An automatic fluid replacement device is adapted to be mounted on an opening of a storage barrel. The automatic fluid replacement device includes a robotic arm, at least one fluid convey joint and a controller. The robotic arm has a gripper. The fluid convey joint includes a convey pipe, a sleeve and a sealing bag. The convey pipe is configured to deliver a fluid. The sleeve is sleeved on the convey pipe. The gripper clamps the sleeve. The sealing bag is sleeved on the sleeve. The controller is configured for automatically controlling the robotic arm to move the fluid convey joint into the opening and controlling the sealing bag to be inflated to seal the opening.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.

Abstract: The invention relates to a control unit for a fluid control device wherein the control unit comprises a pressure unit for providing positive and/or negative pressure, at least one first control unit outlet being fluidically connectable to a processing device comprising at least one receptacle for receiving a fluid sample, at least one second control unit outlet being fluidically connectable to a treatment device having a chamber for receiving the processing device, and a connection unit by means of which the pressure unit is fluidically connectable or connected with the first control unit outlet and/or with the second control unit outlet wherein the control unit is adapted to control the processing of the fluid sample in the processing device by applying a positive or negative pressure provided by the pressure unit to the first control unit outlet by means of the connection unit and to control a physical state in the chamber of the treatment device.

Abstract: The invention relates to a method for processing a liquid sample situated in a receptacle, wherein an attachment device is attached to the receptacle such that at least one fluid line protrudes into the liquid sample and a fluid is directly dispensed into the liquid sample through the fluid line and/or a portion of the liquid sample is aspirated into the fluid line.

Abstract: Hydantoin based compounds useful as inhibitors of matrix metalloproteinases (MMPs), particularly macrophage elastase (MMP-12) are described. Also described are related compositions and methods of using the compounds to inhibit MMP-12 and treat diseases mediated by MMP-12, such as asthma, chronic obstructive pulmonary disease (COPD), emphysema, acute lung injury, idiopathic pulmonary fibrosis (IPF), sarcoidosis, systemic sclerosis, liver fibrosis, nonalcoholic steatohepatitis (NASH), arthritis, cancer, heart disease, inflammatory bowel disease (IBD), acute kidney injury (AKI), chronic kidney disease (CKD), Alport syndrome, and nephritis.