Patents by Inventor Cheng-Ho Chung

Cheng-Ho Chung has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition and use thereof
    Publication number: 20230355591
    Abstract: An oral pharmaceutical formulation containing an effective amount of NRC-AN-019 including its pharmaceutically acceptable salts and polymorphs thereof, by dispersing in a polymer system in a final state of subdivision to enhance oral bioavailability. It also compositions for the treatment of Chronic Myeloid Leukemia and other tumors such as head and neck cancer, prostate cancer and the like.
    Type: Application
    Filed: January 8, 2021
    Publication date: November 9, 2023
    Inventors: Chi-Jen HONG, Yen-Fu CHEN, Cheng-Ho CHUNG
  • Processes for producing amide compounds, and their crystalline and salt form
    Publication number: 20230131180
    Abstract: Disclosed is processes for producing amide compounds, and their crystalline and salts form. Herein, one of the amide compounds is represented by the following formula (1): which is characterized by an X-ray diffraction (XRD) pattern having peaks at about 14.2, 15.6, 16.4, 20.1, 20.5 and 21.2°±0.2° 2?.
    Type: Application
    Filed: March 3, 2021
    Publication date: April 27, 2023
    Inventors: Cheng-Ho CHUNG, Shi-Liang TSENG, Hsiang-En HSU
  • Amide compounds and use thereof
    Patent number: 11384060
    Abstract: Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof: (I), in which each of variables R1, R2, R3, R4, R5, A1, A2, A3, A4, X and Y is defined herein. Also disclosed are methods for reducing the glycemic level and treating glucagon-associated disorders with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: July 12, 2022
    Assignee: ALPHALA CO., LTD.
    Inventors: Cheng-Ho Chung, Shi-Liang Tseng, Yung-Ning Yang, Yen-Fu Chen
  • Compound and pharmaceutical composition containing the same
    Patent number: 11174253
    Abstract: Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof: Formula (I), in which each of variables L, R3, R4, Y, Z1, Z2 and Z3 is defined herein. Also disclosed is a method for treating a cancer with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.
    Type: Grant
    Filed: August 1, 2018
    Date of Patent: November 16, 2021
    Assignee: ALPHALA CO., LTD.
    Inventors: Cheng-Ho Chung, Shi-Liang Tseng, Yen-Fu Chen, Jian-Bin Lee
  • Pharmaceutical composition and use thereof
    Publication number: 20210330648
    Abstract: Disclosed is a pharmaceutical composition comprising: an active ingredient of the following formula (I) or a pharmaceutically acceptable salt or solvate thereof present in an amount of 8 wt % to 30 wt %: and two or more excipients at least including a dispersant and a solubilizer present in an amount of 70 wt % to 92 wt %. Also disclosed are methods for reducing the glycemic level and treating disorders associated with glucagon with the aforesaid pharmaceutical composition.
    Type: Application
    Filed: July 2, 2021
    Publication date: October 28, 2021
    Inventors: Chi-Jen HONG, Yen-Fu CHEN, Cheng-Ho CHUNG
  • Amide compounds and use thereof
    Patent number: 10882837
    Abstract: Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof, in which each of variables R1, R2, L, and Z is defined herein. Also disclosed are methods for reducing the glycemic level and treating glucagon-associated disorders with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.
    Type: Grant
    Filed: January 22, 2018
    Date of Patent: January 5, 2021
    Assignee: ALPHALA CO., LTD.
    Inventors: Cheng-Ho Chung, Shi-Liang Tseng, Yung-Ning Yang, Yen-Fu Chen
  • Novel compound and pharmaceutical composition containing the same
    Publication number: 20200172531
    Abstract: Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof: Formula (I), in which each of variables L, R3, R4, Y, Z1, Z2 and Z3 is defined herein. Also disclosed is a method for treating a cancer with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.
    Type: Application
    Filed: August 1, 2018
    Publication date: June 4, 2020
    Inventors: Cheng-Ho CHUNG, Shi-Liang TSENG, Yen-Fu CHEN, Jian-Bin LEE
  • AMIDE COMPOUNDS AND USE THEREOF
    Publication number: 20190345118
    Abstract: Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof, in which each of variables R1, R2, L, and Z is defined herein. Also disclosed are methods for reducing the glycemic level and treating glucagon-associated disorders with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.
    Type: Application
    Filed: January 22, 2018
    Publication date: November 14, 2019
    Inventors: Cheng-Ho CHUNG, Shi-Liang TSENG, Yung-Ning YANG, Yen-Fu CHEN
  • AMIDE COMPOUNDS AND USE THEREOF
    Publication number: 20190337915
    Abstract: Disclosed are compounds of formula (I) below and pharmaceutically acceptable salts thereof: (I), in which each of variables R1, R2, R3, R4, R5, A1, A2, A3, A4, X and Y is defined herein. Also disclosed are methods for reducing the glycemic level and treating glucagon-associated disorders with a compound of formula (I) or a salt thereof and a pharmaceutical composition containing same.
    Type: Application
    Filed: January 22, 2018
    Publication date: November 7, 2019
    Inventors: Cheng-Ho CHUNG, Shi-Liang TSENG, Yung-Ning YANG, Yen-Fu CHEN
  • Methods of Pancreatic Beta Cell Regeneration
    Publication number: 20120270890
    Abstract: Disclosed are new methods for pancreatic ?-cell regeneration and the methods for identifying adult pancreatic endocrine stem cells and the methods for identifying the existence of differentiation processes from adult pancreatic endocrine stem cells toward pancreatic ?-cell fate and a new animal model for pancreatic ?-cell regeneration. The present invention can be utilized in screening and development of new medicines and therapy protocols for diabetes.
    Type: Application
    Filed: April 20, 2012
    Publication date: October 25, 2012
    Inventors: Cheng-Ho Chung, Fred Levine