Abstract: A method for manufacturing a membrane electrode assembly of a fuel cell by solvent pretreatment to the electrolyte membrane of the membrane electrode assembly is disclosed. A prepared electrolyte membrane is soaked in alcohol solvent for pre-expanding the electrolyte membrane at first, a catalyst layer is uniformly coated onto at least one side of the pre-expanded electrolyte membrane, and then the electrolyte membrane is dried for evenly shrinking the electrolyte membrane and the catalyst layer. Finally, the electrolyte membrane with catalyst layers is interposed between two gas diffusion electrodes, and the resulting sheet is pressed with heating to form the membrane electrode assembly.