Abstract: The present application provides a stable topical composition comprising a compound of 1,2,4-thiadiazole derivatives and the related thiourea derivatives. The stable topical composition may be present in various forms, including aqueous gel, cream, and emulsion. The stable topical composition may be stored at refrigerated or ambient condition for a reasonable shelf-life. The present application also provides a method of treating dermatologic disorders mediated by a melanocortin receptor using the stable topical composition. The stable composition may be delivered using a single chamber or dual chamber device. A method of preparing and delivering the stable composition is also provided.

Abstract: The present application provides a stable topical composition comprising a compound of 1,2,4-thiadiazole derivatives and the related thiourea derivatives. The stable topical composition may be present in various forms, including aqueous gel, cream, and emulsion. The stable topical composition may be stored at refrigerated or ambient condition for a reasonable shelf-life. The present application also provides a method of treating dermatologic disorders mediated by a melanocortin receptor using the stable topical composition. The stable composition may be delivered using a single chamber or dual chamber device. A method of preparing and delivering the stable composition is also provided.

Abstract: Methods for enhancing immunogenic response to an antigen, particularly a peptide antigen in a mammalian subject. The method comprises administering a biodegradable polymeric delivery system which comprises one or more antigens of interest and a biologically effective amount of one or more basic additives to the mammalian subject. In a highly preferred embodiment, the basic additive in MgCO3, and the biodegradable polymeric delivery system is a PLGA microparticle. The present invention also relates to the immunogenic compositions used in the present method.

Abstract: A method for making biocompatible polymeric matrices, particularly polymeric particles, that have functional groups on the surface thereof are provided. The method comprises: providing a biocompatible base polymer; providing a surface-active, functional polymer, hereinafter referred to as an “SAFP”; entangling chains of the base polymer with chains of the SAFP, both of which are in a mobile state; and then demobilizing the base polymer chains to form a polymeric particle or matrix having a specific geometry. Polymeric particles having functional groups on the surface thereof are also provided. The particles comprise a biocompatible base polymer and an SAFP. The SAFP comprises one or more interactive regions for physically cross-linking with the base polymer, and one or more hydrophilic regions. The particles have a core region and an outer region having a an outer surface. The core region contains a plurality of biocompatible base polymer chains.