Patents by Inventor Cheng-Ko Liu

Cheng-Ko Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8470379
    Abstract: A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.
    Type: Grant
    Filed: October 25, 2010
    Date of Patent: June 25, 2013
    Assignee: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei
  • Publication number: 20110038966
    Abstract: A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.
    Type: Application
    Filed: October 25, 2010
    Publication date: February 17, 2011
    Applicant: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien KO, Mo-Chi CHENG, Cheng-Ko LIU, Jen-Wei CHEN, Fen CHEN, Chao-Chi YEI
  • Patent number: 7842318
    Abstract: The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: November 30, 2010
    Assignee: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei
  • Patent number: 7569238
    Abstract: An antitussive agent. A composition for relieving, preventing and/or treating cough includes a sufficient amount of Cynanchi Atrati Radix extract as an active component. The effective Cynanchi Atrati Radix extract is prepared by extracting Cynanchi Atrati Radix with water, ethanol, hexane, ethyl acetate or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.
    Type: Grant
    Filed: April 28, 2003
    Date of Patent: August 4, 2009
    Assignee: Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Wei-Ja Wang, Cheng-Ko Liu, Pin-Fen Chen, Yu-Feng Han, Mai-Yu Lee
  • Publication number: 20090104293
    Abstract: The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.
    Type: Application
    Filed: October 18, 2007
    Publication date: April 23, 2009
    Applicant: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei
  • Patent number: 7223425
    Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: May 29, 2007
    Assignee: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
  • Patent number: 7179496
    Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: February 20, 2007
    Assignee: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
  • Patent number: 7175861
    Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: February 13, 2007
    Assignee: Medical and Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
  • Patent number: 6911222
    Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
    Type: Grant
    Filed: January 3, 2003
    Date of Patent: June 28, 2005
    Assignee: Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
  • Publication number: 20050008720
    Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
    Type: Application
    Filed: August 11, 2004
    Publication date: January 13, 2005
    Applicant: Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
  • Publication number: 20050008721
    Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
    Type: Application
    Filed: August 11, 2004
    Publication date: January 13, 2005
    Applicant: Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
  • Publication number: 20050008719
    Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
    Type: Application
    Filed: August 11, 2004
    Publication date: January 13, 2005
    Applicant: Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
  • Publication number: 20040213863
    Abstract: An antitussive agent. A composition for relieving, preventing and/or treating cough includes a sufficient amount of Cynanchi Atrati Radix extract as an active component. The effective Cynanchi Atrati Radix extract is prepared by extracting Cynanchi Atrati Radix with water, ethanol, hexane, ethyl acetate or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.
    Type: Application
    Filed: April 28, 2003
    Publication date: October 28, 2004
    Inventors: Feng-Nien Ko, Wei-Ja Wang, Cheng-Ko Liu, Pin-Fen Chen, Yu-Feng Han, Mai-Yu Lee
  • Publication number: 20030133999
    Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.
    Type: Application
    Filed: January 3, 2003
    Publication date: July 17, 2003
    Applicant: Pharmaceutical Industry Technology and Development Center
    Inventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen