Patents by Inventor Cheng-Ko Liu
Cheng-Ko Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8470379Abstract: A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.Type: GrantFiled: October 25, 2010Date of Patent: June 25, 2013Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei
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Publication number: 20110038966Abstract: A new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a normal phase chromatography column, and eluting the column with a first eluent having a polarity lower than that of a mixture of n-hexane and ethyl acetate in a weight ratio of 6:4 to obtain a potent fraction. Preferably, the potent fraction is substantially free of both 6-gingerol and 6-shogaol.Type: ApplicationFiled: October 25, 2010Publication date: February 17, 2011Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien KO, Mo-Chi CHENG, Cheng-Ko LIU, Jen-Wei CHEN, Fen CHEN, Chao-Chi YEI
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Patent number: 7842318Abstract: The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.Type: GrantFiled: October 18, 2007Date of Patent: November 30, 2010Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei
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Patent number: 7569238Abstract: An antitussive agent. A composition for relieving, preventing and/or treating cough includes a sufficient amount of Cynanchi Atrati Radix extract as an active component. The effective Cynanchi Atrati Radix extract is prepared by extracting Cynanchi Atrati Radix with water, ethanol, hexane, ethyl acetate or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.Type: GrantFiled: April 28, 2003Date of Patent: August 4, 2009Assignee: Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Wei-Ja Wang, Cheng-Ko Liu, Pin-Fen Chen, Yu-Feng Han, Mai-Yu Lee
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Publication number: 20090104293Abstract: The present invention discloses a new use of a potent product extracted from rhizomes of Zingiber officinale in treating a disease associated with Helicobacter pylori such as gastritis, gastric ulcer or duodenal ulcer in a patient. The potent product is prepared by a process including the steps of a) preparing a crude extract from rhizomes of Zingiber officinale, said crude extract comprising 6-gingerol and 6-shogaol; b) introducing the crude extract to a reverse phase chromatography column, and eluting the column with a first eluent having a polarity lower than water to obtain a first potent fraction or a second eluent having a polarity lower than that of the first eluent to obtain a second potent fraction. Preferably, the second potent fraction is substantially free of both 6-gingerol and 6-shogaol.Type: ApplicationFiled: October 18, 2007Publication date: April 23, 2009Applicant: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Mo-Chi Cheng, Cheng-Ko Liu, Jen-Wei Chen, Fen Chen, Chao-Chi Yei
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Patent number: 7223425Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.Type: GrantFiled: August 11, 2004Date of Patent: May 29, 2007Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
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Patent number: 7179496Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.Type: GrantFiled: August 11, 2004Date of Patent: February 20, 2007Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
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Patent number: 7175861Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.Type: GrantFiled: August 11, 2004Date of Patent: February 13, 2007Assignee: Medical and Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
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Patent number: 6911222Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.Type: GrantFiled: January 3, 2003Date of Patent: June 28, 2005Assignee: Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
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Publication number: 20050008720Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.Type: ApplicationFiled: August 11, 2004Publication date: January 13, 2005Applicant: Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
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Publication number: 20050008721Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.Type: ApplicationFiled: August 11, 2004Publication date: January 13, 2005Applicant: Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
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Publication number: 20050008719Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.Type: ApplicationFiled: August 11, 2004Publication date: January 13, 2005Applicant: Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen
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Publication number: 20040213863Abstract: An antitussive agent. A composition for relieving, preventing and/or treating cough includes a sufficient amount of Cynanchi Atrati Radix extract as an active component. The effective Cynanchi Atrati Radix extract is prepared by extracting Cynanchi Atrati Radix with water, ethanol, hexane, ethyl acetate or a combination thereof. The crude extract can be further fractioned by ultrafiltration or reverse phase column.Type: ApplicationFiled: April 28, 2003Publication date: October 28, 2004Inventors: Feng-Nien Ko, Wei-Ja Wang, Cheng-Ko Liu, Pin-Fen Chen, Yu-Feng Han, Mai-Yu Lee
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Publication number: 20030133999Abstract: A pharmaceutical composition contains a therapeutically effective amount of an active ingredient, in admixture with a pharmaceutically acceptable carrier or diluent for the active ingredient, in which the active ingredient is i) a polar solvent extract of Polygala, the polar solvent being water or a mixture of water and methanol or ethanol; ii) an aqueous fraction resulting from an extraction of the polar solvent extract with an organic solvent; iii) an organic eluate by introducing the polar solvent extract or the aqueous fraction into a reverse phase chromatography column, and eluting the column with water and an organic solvent; or iv) a filtrate having a molecular mass less than 30000 in the organic eluate.Type: ApplicationFiled: January 3, 2003Publication date: July 17, 2003Applicant: Pharmaceutical Industry Technology and Development CenterInventors: Feng-Nien Ko, Cheng-Ko Liu, Yu-Feng Han, Pin-Fun Chen