Patents by Inventor Cheng-Wei Tom Chang

Cheng-Wei Tom Chang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Amphiphilic Kanamycin Compositions and Methods
    Publication number: 20210230203
    Abstract: The present relates to novel bioactive amphiphilic kanamycin compounds having the general formula of: where R may be a C4 to C20 branched or straight chained alkyl group or a substituted or unsubstituted aryl group. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating and preventing various fungal and bacterial diseases.
    Type: Application
    Filed: January 25, 2021
    Publication date: July 29, 2021
    Applicant: Utah State University
    Inventors: Cheng-Wei Tom Chang, JON Y TAKEMOTO
  • AMPHIPHILIC AMINOGLYCOSIDE CONNEXIN HEMICHANNEL INHIBITORS
    Publication number: 20210163521
    Abstract: The present invention includes novel molecules and methods of using an amphiphilic kanamycin molecule having substitutions at the O-4?, O-6?, or O-4? and O-6? positions having reduced antimicrobial activity for targeting Connexin Hemichannels.
    Type: Application
    Filed: December 11, 2020
    Publication date: June 3, 2021
    Inventors: Guillermo A. Altenberg, Cheng-Wei Tom Chang
  • Aminoglycoside and azole compositions and methods
    Patent number: 9669044
    Abstract: The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
    Type: Grant
    Filed: May 19, 2014
    Date of Patent: June 6, 2017
    Assignee: Utah State University
    Inventors: Jon Y. Takemoto, Cheng-wei Tom Chang, Sanjib K. Shrestha, Michelle Grilley
  • Aminoglycoside and Azole Compositions and Methods
    Publication number: 20140256665
    Abstract: The present invention relates to novel fungicidal compound including an aminoglycoside analog having certain substituents at the 6 position of ring III that exhibit improved antifungal activity but possess minimal antibacterial properties in combination with fungicidal azoles. The aminoglycoside compounds are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
    Type: Application
    Filed: May 19, 2014
    Publication date: September 11, 2014
    Applicant: UTAH STATE UNIVERSITY
    Inventors: Jon Y. Takemoto, Cheng-wei Tom Chang, Sanjib K. Shrestha, Michelle Grilley
  • AMINOGLYCOSIDES: SYNTHESIS AND USE AS ANTIFUNGALS
    Publication number: 20120316125
    Abstract: The present invention relates to novel aminoglycoside analogs having certain substituents at the 6 position of ring III which exhibit improved antifungal activity but possess minimal antibacterial properties. The compounds of the present invention are analogues of kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
    Type: Application
    Filed: December 12, 2011
    Publication date: December 13, 2012
    Inventors: Cheng-Wei Tom Chang, Jon Takemoto
  • Aminoglycosides: Synthesis and Use as Antifungals
    Publication number: 20110130357
    Abstract: The present invention relates to novel aminoglycoside analogs having certain substituents at the 6 position of ring III which exhibit improved antifungal activity but possess minimal antibacterial properties. The compounds of the present invention are analogues of kanamycin B and kanamycin A. Also provided are methods of synthesizing and methods of using the compounds of the present invention. The compounds of the present invention are useful in treating or preventing fungal disease.
    Type: Application
    Filed: December 14, 2010
    Publication date: June 2, 2011
    Applicant: Utah State University
    Inventors: Cheng-wei Tom Chang, C. Kent Evans, Jon Y. Takemoto
  • Anti bacterial compounds
    Patent number: 7371733
    Abstract: The invention relates to novel paranmycin compounds that have activity against gram positive and gram negative bacteria, preferably bacteria that are resistant to other antibiotics.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: May 13, 2008
    Assignee: Utah State University
    Inventor: Cheng-Wei Tom Chang