Patents by Inventor Cheng XIE

Cheng XIE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240366811
    Abstract: The present disclosure relates to a radioactive polypeptide conjugate drug and for use thereof in nuclear medicine as a tracer, an imaging agent, and for treating various disease states associated with tumors is provided.
    Type: Application
    Filed: April 26, 2024
    Publication date: November 7, 2024
    Applicant: TIANJIN CONJUSTAR BIOLOGICS CO., LTD.
    Inventors: Shuyi TANG, Cheng XIE, Zhiping CUI
  • Patent number: 12030897
    Abstract: The present invention relates to a group of pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 8, 2019
    Date of Patent: July 9, 2024
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Kevin X Chen, Fen Jiang, Xinde Chen, Li Zhang, Zhaoguo Chen, Yanxin Yu, Kai Zhou, Boyu Hu, Cheng Xie, Shuhui Chen
  • Publication number: 20240153188
    Abstract: In various examples, systems and methods are disclosed relating to generating physics-plausible whole body motion, including determining a mesh sequence corresponding to a motion of at least one dynamic character of one or more dynamic characters and a mesh of a terrain using a video sequence, determining using a generative model and based at least one the mesh sequence and the mesh of the terrain, an occlusion-free motion of the at least one dynamic character by infilling physics-plausible character motions in the mesh sequence for at least one frame of the video sequence that includes an occlusion of at least a portion of the at least one dynamic character, and determining physics-plausible whole body motion of the at least one dynamic character by applying physics-based imitation upon the occlusion-free motion.
    Type: Application
    Filed: August 24, 2023
    Publication date: May 9, 2024
    Applicant: NVIDIA Corporation
    Inventors: Jingbo WANG, Ye YUAN, Cheng XIE, Sanja FIDLER, Jan KAUTZ, Umar IQBAL, Zan GOJCIC, Sameh KHAMIS
  • Publication number: 20230410397
    Abstract: Apparatuses, systems, and techniques are presented to generate images representing realistic motion or activity. In at least one embodiment, one or more neural networks are used to generate one or more images of one or more characters performing one or more actions based, at least in part, upon one or more physical capabilities of the one or more characters.
    Type: Application
    Filed: June 16, 2022
    Publication date: December 21, 2023
    Inventors: Tingwu Wang, Yunrong Guo, Cheng Xie, Xue Bin Peng, Sanja Fidler
  • Publication number: 20230365558
    Abstract: A series of tetrahydroisoquinoline derivatives and the crystal forms thereof. Specifically disclosed are a compound as represented by formula (VII), a crystal form thereof, and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 18, 2021
    Publication date: November 16, 2023
    Inventors: Kevin X CHEN, Zuhao GUO, Yanxin YU, Boyu HU, Jingjing WANG, Zhaoguo CHEN, Cheng XIE, Jian XIONG, Yongbo FANG, Yingtao LIU, Jian LI, Shuhui CHEN
  • Publication number: 20230339943
    Abstract: The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: June 19, 2023
    Publication date: October 26, 2023
    Inventors: Jian XIONG, Chaofeng LONG, Jingjing WANG, Xiaoxin CHEN, KEVIN X. CHEN, Cheng XIE, Peng LI, Xuanjia PENG, Jian Li, Shuhui Chen
  • Patent number: 11725009
    Abstract: The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: August 24, 2021
    Date of Patent: August 15, 2023
    Assignee: GUANGDONG RAYNOVENT BIOTECH CO., LTD.
    Inventors: Jian Xiong, Chaofeng Long, Jingjing Wang, Xiaoxin Chen, Kevin X Chen, Cheng Xie, Peng Li, Xuanjia Peng, Jian Li, Shuhui Chen
  • Patent number: 11649239
    Abstract: Disclosed in the present invention are a crystal form of a [1,2,4]triazolo[1,5-c]pyrimidine compound and a preparation method thereof. Further disclosed is a use of the crystal form in the preparation of a medicament for treating A2A receptor related diseases.
    Type: Grant
    Filed: April 28, 2019
    Date of Patent: May 16, 2023
    Assignee: Medshine Discovery Inc.
    Inventors: Kevin X. Chen, Yanxin Yu, Xinde Chen, Li Zhang, Zhaoguo Chen, Cheng Xie
  • Patent number: 11535613
    Abstract: Disclosed are a crystal form and a salt form of a pyrazolopridine compound, and a preparation method therefor. Further included is the use of the crystal form in preparing anti-influenza virus drugs.
    Type: Grant
    Filed: March 5, 2019
    Date of Patent: December 27, 2022
    Assignee: GUANGDONG RAYNOVENT BIOTECH CO., LTD.
    Inventors: Jian Xiong, Xiaoxin Chen, Jingjing Wang, Zhuowei Liu, Kevin X Chen, Chengwu Liu, Cheng Xie, Chaofeng Long, Peng Li, Jian Li, Shuhui Chen
  • Patent number: 11466036
    Abstract: A borate compound of an azetidine derivative, relating in particular to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof or a geometric isomer thereof, as well as a use thereof in the preparation of a drug used for the treatment or prevention of multiple myeloma.
    Type: Grant
    Filed: August 2, 2019
    Date of Patent: October 11, 2022
    Assignee: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
    Inventors: Jian Xiong, Cheng Xie, Xiongbin Xu, Kevin X Chen, Jian Li, Shuhui Chen, Aiming Zhang, Xiquan Zhang, Xin Tian
  • Patent number: 11361507
    Abstract: Estimating a three-dimensional (3D) pose and shape of an articulated body mesh is useful for many different applications including health and fitness, entertainment, and computer graphics. A set of estimated 3D keypoint positions for a human body structure are processed to compute parameters defining the pose and shape of a parametric human body mesh using a set of geometric operations. During processing, 3D keypoints are extracted from the parametric human body mesh and a set of rotations are computed to align the extracted 3D keypoints with the estimated 3D keypoints. The set of rotations may correctly position a particular 3D keypoint location at a “joint”, but an arbitrary number of rotations of the “joint” keypoint may produce a twist in a connection to a child keypoint. Rules are applied to the set of rotations to resolve ambiguous twists and articulate the parametric human body mesh according to the computed parameters.
    Type: Grant
    Filed: May 7, 2021
    Date of Patent: June 14, 2022
    Assignee: NVIDIA Corporation
    Inventors: Umar Iqbal, Pavlo Molchanov, Jan Kautz, Yun Rong Guo, Cheng Xie
  • Publication number: 20220135558
    Abstract: The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: August 24, 2021
    Publication date: May 5, 2022
    Inventors: Jian Xiong, Chaofeng Long, Jingjing Wang, Xiaoxin Chen, Kevin X Chen, Cheng Xie, Peng Li, Xuanjia Peng, Jian Li, Shuhui Chen
  • Publication number: 20210323979
    Abstract: The present invention relates to a group of pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and an application thereof in the preparation of a drug that serves as an HER2 inhibitor. Specifically, the present invention relates to a compound represented by formula (I), an isomer thereof or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 8, 2019
    Publication date: October 21, 2021
    Applicant: MEDSHINE DISCOVERY INC.
    Inventors: Kevin X CHEN, Fen JIANG, Xinde CHEN, Li ZHANG, Zhaoguo CHEN, Yanxin YU, Kai ZHOU, Boyu HU, Cheng XIE, Shuhui CHEN
  • Patent number: 11136319
    Abstract: The present invention discloses a class of anti-influenza virus compounds, and the use thereof in the preparation of a drug for treating diseases associated with influenza viruses. In particular, the present invention discloses a compound represented by formula (I) and a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: October 5, 2021
    Assignee: Guangdong Raynovent Biotech Co., Ltd.
    Inventors: Jian Xiong, Chaofeng Long, Jingjing Wang, Xiaoxin Chen, Kevin X Chen, Cheng Xie, Peng Li, Xuanjia Peng, Jian Li, Shuhui Chen
  • Patent number: 11117899
    Abstract: Provided are a compound represented by formula (I), an isomer or a pharmaceutically acceptable salt thereof, and an application of the same in preparing a drug for treating a disease related to A2A receptor. The R1, R2, R3, ring A, ring B, n, and m are as defined in the specification.
    Type: Grant
    Filed: April 8, 2018
    Date of Patent: September 14, 2021
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Kevin X Chen, Yanxin Yu, Xinde Chen, Li Zhang, Zhaoguo Chen, Cheng Xie, Xiaofei Wang, Linghui Wu, Guoping Hu, Jian Li, Shuhui Chen
  • Publication number: 20210224467
    Abstract: Described embodiments provide a method, computer program product, and computer system for generating, by a computing device, a data file including at least one property from a first cascading style sheet (CSS) file, the at least one property defining a scripting language object. A scripting language file may be generated, the scripting language file may include a scripting language variable for the scripting language object. A second CSS file may be generated by replacing the at least one property from the data file with the scripting language variable of the scripting language file. An element of a webpage referenced by the scripting language object may be rendered based upon, at least in part, the scripting language variable of the second CSS file.
    Type: Application
    Filed: April 6, 2021
    Publication date: July 22, 2021
    Inventors: Zhen Zeng, Cheng Xie
  • Patent number: 11066411
    Abstract: Provided are a compound represented by formula (I), an isomer or a pharmaceutically acceptable salt thereof, and an application of the same in preparing a drug for treating a disease related to A2A receptor. The R1, R2, R3, ring A, ring B, n, and m are as defined in the specification.
    Type: Grant
    Filed: April 8, 2018
    Date of Patent: July 20, 2021
    Assignee: MEDSHINE DISCOVERY INC.
    Inventors: Kevin X Chen, Yanxin Yu, Xinde Chen, Li Zhang, Zhaoguo Chen, Cheng Xie, Xiaofei Wang, Linghui Wu, Guoping Hu, Jian Li, Shuhui Chen
  • Publication number: 20210163507
    Abstract: A borate compound of an azetidine derivative, relating in particular to a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, a tautomer thereof, a stereoisomer thereof or a geometric isomer thereof, as well as a use thereof in the preparation of a drug used for the treatment or prevention of multiple myeloma.
    Type: Application
    Filed: August 2, 2019
    Publication date: June 3, 2021
    Inventors: Jian Xiong, Cheng Xie, Xiongbin Xu, Kevin X Chen, Jian Li, Shuhui Chen, Aiming Zhang, Xiquan Zhang, Xin Tian
  • Patent number: 11014943
    Abstract: Disclosed in the present application are a compound represented by formula (I), or a pharmaceutically acceptable salt, a tautomer thereof, a stereoisomer thereof, or a geometrical isomer thereof, and uses thereof in the preparation of drugs for treating or preventing multiple myeloma.
    Type: Grant
    Filed: February 28, 2018
    Date of Patent: May 25, 2021
    Assignee: CHIA TAI TIANQING PHARMACEUTICAL GROUP GO., LTD.
    Inventors: Jian Xiong, Cheng Xie, Kevin X Chen, Xiongbin Xu, Xuejin Zhang, Zhen Gong, Jian Li, Shuhui Chen, Aiming Zhang, Zhulian Jiang, Xiquan Zhang, Xin Tian
  • Patent number: 10970469
    Abstract: Described embodiments provide a method, computer program product, and computer system for generating, by a computing device, a data file including at least one property from a first cascading style sheet (CSS) file, the at least one property defining a scripting language object. A scripting language file may be generated, the scripting language file may include a scripting language variable for the scripting language object. A second CSS file may be generated by replacing the at least one property from the data file with the scripting language variable of the scripting language file. An element of a webpage referenced by the scripting language object may be rendered based upon, at least in part, the scripting language variable of the second CSS file.
    Type: Grant
    Filed: August 19, 2019
    Date of Patent: April 6, 2021
    Assignee: Citrix Systems, Inc.
    Inventors: Zhen Zeng, Cheng Xie