Patents by Inventor Cheng Xiong
Cheng Xiong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240299504Abstract: A method of treating Alzheimer's disease (AD) in a subject includes administering to the subject a therapeutically effective amount of at least one parathyroid hormone type 1 receptor (PTH1R) agonist.Type: ApplicationFiled: March 6, 2024Publication date: September 12, 2024Inventors: Wen-Cheng Xiong, Lin Mei, Li Chen, Lei Xiong
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Publication number: 20240072327Abstract: This application discloses a battery box. The battery box includes a controller, a first sensor, and a spraying apparatus and an extinguishing agent pipeline that are located above a battery module. The controller is electrically connected to the first sensor and the spraying apparatus. The spraying apparatus is connected to the extinguishing agent pipeline. The first sensor is configured to detect a temperature of the battery box, and send a first electrical signal to the controller. The controller is configured to control the spraying apparatus to spray an extinguishing agent to the battery module. According to the solution of this application, when thermal runaway occurs in the battery box, and the temperature exceeds a set threshold, a fire may be extinguished in time, to avoid spreading of the fire and reduce a loss.Type: ApplicationFiled: August 22, 2023Publication date: February 29, 2024Inventors: Lei Chen, Cong Cheng, Jie Xie, Cheng Xiong, Zhuangzhuang Jia, Qingsong Wang, Wenxin Mei
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Patent number: 11348603Abstract: A slider comprises an air bearing surface having a leading edge at a first end of the air bearing surface; a trailing edge at a second end of the air bearing surface, wherein the first end is opposite to the second end; a first region adjacent to the trailing edge, wherein the first region comprises one or more transducer elements; and a second region adjacent to the first region and the leading edge. The air bearing surface has a protective overcoat layer as an outermost layer, wherein the protective overcoat layer extends across the entire air bearing surface. The air bearing surface comprises a lapped surface and a plurality of milled surfaces, wherein a surface potential difference between the lapped surface and a milled surface is 0+/?50 milliVolts or less as measured according to Kelvin Probe Force Microscopy (KPFM).Type: GrantFiled: July 14, 2021Date of Patent: May 31, 2022Assignee: Seagate Technologv LLCInventors: Amy Jo Bergerud, Iris Cheng Xiong
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Publication number: 20210343310Abstract: The present disclosure relates to kiss lapping sliders after patterning an air bearing surface pattern, followed by applying a protective overcoat to the air bearing surface. The present disclosure also involves related sliders.Type: ApplicationFiled: July 14, 2021Publication date: November 4, 2021Inventors: Amy Jo Bergerud, Iris Cheng Xiong
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Patent number: 11094339Abstract: The present disclosure relates to kiss lapping sliders after patterning an air bearing surface pattern, followed by applying a protective overcoat to the air bearing surface. The present disclosure also involves related sliders.Type: GrantFiled: April 13, 2020Date of Patent: August 17, 2021Assignee: Seagate Technology LLCInventors: Amy Jo Bergerud, Iris Cheng Xiong
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Patent number: 10877047Abstract: The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.Type: GrantFiled: January 29, 2018Date of Patent: December 29, 2020Assignee: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.Inventors: Lin Mei, Wen-Cheng Xiong, Bin Zhang, Chengyong Shen
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Patent number: 10857517Abstract: A porous chiral material of formula [M(L)1.5(A)]+X? wherein M is a metal ion; L is a nitrogen-containing bidentate ligand; A is the anion of mandelic acid or a related acid; and X? is an anion.Type: GrantFiled: August 22, 2016Date of Patent: December 8, 2020Assignees: NANKAI UNIVERSITY, UNIVERSITY OF LIMERICKInventors: Shi-Yuan Zhang, Cheng-Xiong Yang, Wei Shi, Xiu-Ping Yan, Peng Cheng, Michael J. Zaworotko
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Publication number: 20200009531Abstract: A porous chiral material of formula [M(L)1.Type: ApplicationFiled: August 22, 2016Publication date: January 9, 2020Inventors: Wei SHI, Peng CHENG, Xiu-Ping YAN, Cheng-Xiong YANG, Michael J. ZAWOROTKO, Shi-Yuan ZHANG
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Publication number: 20180231572Abstract: The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.Type: ApplicationFiled: January 29, 2018Publication date: August 16, 2018Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.Inventors: Lin Mei, Wen-Cheng Xiong, Bin Zhang, Chengyong Shen
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Patent number: 9897614Abstract: The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.Type: GrantFiled: December 11, 2015Date of Patent: February 20, 2018Assignee: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.Inventors: Lin Mei, Wen-Cheng Xiong, Bin Zhang, Chengyong Shen
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Patent number: 9493542Abstract: Compositions that inhibit or block the interaction between Erbin and ErbB2 and methods of their use are provided. Preferred compositions include peptides that inhibit or block Erbin and ErbB2 interaction under physiologic conditions in a subject. One embodiment provides an isolated peptide fragment of ErbB2 including the C-terminal 15 amino acids of ErbB2. The peptide fragment can be about 15 to 27 amino acids in length.Type: GrantFiled: February 24, 2014Date of Patent: November 15, 2016Assignee: Augusta University Research Institute, Inc.Inventors: Lin Mei, Wen-Cheng Xiong, Cheng-Yong Shen, Yan-Mei Tao, Shi-Wen Luo
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Publication number: 20160187355Abstract: The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.Type: ApplicationFiled: December 11, 2015Publication date: June 30, 2016Inventors: Lin Mei, Wen-Cheng Xiong, Bin Zhang, Chengyong Shen
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Patent number: 9244082Abstract: The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.Type: GrantFiled: April 20, 2012Date of Patent: January 26, 2016Assignee: Georgia Regents Research Institute, Inc.Inventors: Lin Mei, Wen-Cheng Xiong, Bin Zhang, Chengyong Shen
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Patent number: 9204155Abstract: An apparatus comprising a codec configured to predict an intra mode for a considered block based on a plurality of group numbers and a plurality of corresponding group indices for a plurality used modes of a plurality of adjacent blocks to the considered block, wherein a group number corresponding to an actual intra mode for the considered block is coded and sent if the predicted intra mode does not match the actual intra mode. Also disclosed is a network component comprising a processor configured to predict an intra mode for a considered block based on a minimum group number and a minimum group index of two used modes for two adjacent blocks of the considered block, and a transmitter configured to send coded bits of a group number for an actual intra mode for the considered block if the actual intra mode does not match the predicted intra mode.Type: GrantFiled: September 28, 2011Date of Patent: December 1, 2015Assignee: Futurewei Technologies, Inc.Inventors: Lingzhi Liu, Guichun Li, Nam Ling, Jianhua Zheng, Cheng-Xiong Zhang
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Publication number: 20140243268Abstract: Compositions that inhibit or block the interaction between Erbin and ErbB2 and methods of their use are provided. Preferred compositions include peptides that inhibit or block Erbin and ErbB2 interaction under physiologic conditions in a subject. One embodiment provides an isolated peptide fragment of ErbB2 including the C-terminal 15 amino acids of ErbB2. The peptide fragment can be about 15 to 27 amino acids in length.Type: ApplicationFiled: February 24, 2014Publication date: August 28, 2014Applicant: Georgia Regents Research Institute, Inc.Inventors: Lin Mei, Wen-Cheng Xiong, Cheng-Yong Shen, Yan-Mei Tao, Shi-Wen Luo
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Patent number: 8524228Abstract: Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to inhibit or reduce fusion of male gametes with female gametes in a female subject Still another embodiment provides a method for diagnosing male infertility by determining the amount of netrin-1 in a sample of epididymal fluid or semen from a male subject, comparing the amount of netting-1 in the sample to levels of netrin-1 in samples of epididymal fluid or semen from fertile males, wherein levels of netrin-1 in the sample from the male subject that are higher or lower than levels of netrin-1 in samples from fertile males are indicative of male infertility in the male subject.Type: GrantFiled: November 3, 2008Date of Patent: September 3, 2013Assignee: Medical College of Georgia Research Institute, Inc.Inventors: Wen-Cheng Xiong, Jae-Ho Lee, Lin Mei
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Patent number: 8477845Abstract: An apparatus comprising an inter-prediction motion compensation unit, a transform unit coupled to the inter-prediction motion compensation unit, a quantization unit coupled to the transform unit such that the transform unit is positioned between the inter-prediction motion compensation unit and the quantization unit, a scanning unit coupled to the quantization unit such that the quantization unit is positioned between the transform unit and the scanning unit, and an adaptive scan order predictor unit coupled to the inter-prediction motion compensation unit, the quantization unit, and the scanning unit. An apparatus comprising an entropy decoding unit, an inverse scanning unit coupled to the entropy decoding unit, an inverse quantization unit coupled to the inverse scanning unit such that the inverse scanning unit is positioned between the entropy coding unit and the inverse quantization unit, and an adaptive scan order predictor unit coupled to the entropy decoding unit and the inverse scanning unit.Type: GrantFiled: October 15, 2010Date of Patent: July 2, 2013Assignee: Futurewei Technologies, Inc.Inventors: Lingzhi Liu, Xiang Li, Jianhua Zheng, Nam Ling, Cheng-Xiong Zhang
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Publication number: 20130108616Abstract: The present invention includes methods for the detection of neurotransmission or developmental disorders, including, but not limited to, myasthenia gravis that is seronegative for autoantibodies to the acetylcholine receptor (AChR) and/or muscle specific tyrosine kinase (MuSK), the method including detecting autoantibodies that bind to LRP4, or an epitope thereof. Also included are methods for the treatment of an individual suffering from a neurotransmission disorder, the method including detecting in a bodily fluid of the individual autoantibodies that bind to LRP4, or an epitope thereof, and administering to the patient an effective amount an immunosuppressant and/or another appropriate therapeutic modality. Also included are antibodies that bind to autoantibodies to LRP4 and kits for the detection of neurotransmission or developmental disorders.Type: ApplicationFiled: April 20, 2012Publication date: May 2, 2013Inventors: Lin Mei, Wen-Cheng Xiong, Bin Zhang, Changyong Shen
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Publication number: 20120082221Abstract: An apparatus comprising a codec configured to predict an intra mode for a considered block based on a plurality of group numbers and a plurality of corresponding group indices for a plurality used modes of a plurality of adjacent blocks to the considered block, wherein a group number corresponding to an actual intra mode for the considered block is coded and sent if the predicted intra mode does not match the actual intra mode. Also disclosed is a network component comprising a processor configured to predict an intra mode for a considered block based on a minimum group number and a minimum group index of two used modes for two adjacent blocks of the considered block, and a transmitter configured to send coded bits of a group number for an actual intra mode for the considered block if the actual intra mode does not match the predicted intra mode.Type: ApplicationFiled: September 28, 2011Publication date: April 5, 2012Applicant: FUTUREWEI TECHNOLOGIES, INC.Inventors: Lingzhi Liu, Guichun Li, Nam Ling, Jianhua Zheng, Cheng-Xiong Zhang
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Publication number: 20120039881Abstract: Methods and compositions for modulating GABA release in a subject are provided. A preferred embodiment provides a composition containing an effective amount of an ErbB4 ligand to enhance or promote GABA release, i.e., GABAergic transmission. The ErbB4 ligand can be an agonist ligand or an antagonist ligand depending on the disorder to be treated. Methods for treating neurological disorders are also provided. Representative disorders that can be treated include, but are not limited to schizophrenia, epilepsy, depression and anxiety, insomnia, stroke, pain, bipolar, autism, or a combination thereof. By increasing GABA release a sedative effective can be induced in the subject. Methods for inducing a stimulatory effect in a subject are also provided. In these methods, an effective amount of an ErbB4 antagonist ligand is administered to the subject to reduce or inhibit GABA release in the subject.Type: ApplicationFiled: October 21, 2011Publication date: February 16, 2012Inventors: Lin Mei, Wen-Cheng Xiong, Ran-Sook Woo, Xiaoming Li