Abstract: The present disclosure provides an immunoconjugate includes an antibody comprising an antigen-binding fragment that specifically binds to an epitope in mesothelin, N-glycan binding domain and an N-glycan; a linker linking to the N-glycan; and a payload A and a payload B conjugated to the linker, respectively; wherein the payload A and the payload B are the same or different. A pharmaceutical composition comprises the immunoconjugate and a method for treating cancer are also provided in the disclosure.

Abstract: A lamination chuck for lamination of film materials includes a support layer and a top layer. The top layer is disposed on the support layer. The top layer includes a polymeric material having a Shore A hardness lower than a Shore hardness of a material of the support layer. The top layer and the support layer have at least one vacuum channel formed therethrough, vertically extending from a top surface of the top layer to a bottom surface of the support layer.

Abstract: An operation-indication mode switching structure, a circuit, and a method for operating the same are provided. The operation-indication mode switching structure is disposed on a housing of a device, and includes a switching mechanism that is used to switch multiple operation-indication modes. The switching mechanism is selectively connected with one of multiple signal terminals. When the switching mechanism is manipulated to switch to one of the operation-indication modes, a control unit of the device receives an operation-indication mode switching signal generated by the switching mechanism conducting or circuit-shorting one of the multiple signal terminals. A corresponding operation-indication mode that is a covert mode, a stealth mode, or a normal mode can be determined. The control unit is used to control an indication function of the device according to the operation-indication mode that is switched to.

Abstract: A body-worn camera and an operation method thereof are provided, and the body-worn camera a central processing unit, a video recording module, a turntable, and a main button. The video recording module is electrically connected to the central processing unit. The turntable is electrically connected to the central processing unit. The main button is electrically connected to the central processing unit. After the video recording module completes recording a video, when the central processing unit receives a category mode signal from the turntable and receives a category name confirmation signal from the main button, the central processing unit executes a video tagging program, and the video tagging program saves a corresponding relationship between a category name and the video.

Abstract: An optical device is provided. The optical device includes a ring waveguide and a bus waveguide. The ring waveguide includes a coupling region. The bus waveguide is disposed adjacent to and spaced apart from the coupling region of the ring waveguide. The bus waveguide includes a coupling structure corresponding to the coupling region.

Abstract: A method is provided for forming an integrated circuit (IC) chip package structure. The method includes providing a substrate for an interposer, and forming a conductive interconnect structure in and on the substrate for connecting a group of selected IC dies. The method includes forming warpage-reducing trenches in non-routing regions of the interposer, wherein the warpage-reducing trenches are sized and positioned based on a warpage characteristic to reduce the warpage of the chip package structure. The method also includes depositing a warpage-relief material in the warpage-reducing trenches according to the warpage characteristic to reduce the warpage of the chip package structure, and bonding the group of selected IC dies to the interposer to form a chip package structure.

Abstract: A method of performing automatic tuning on a deep learning model includes: utilizing an instruction-based learned cost model to estimate a first type of operational performance metrics based on a tuned configuration of layer fusion and tensor tiling; utilizing statistical data gathered during a compilation process of the deep learning model to determine a second type of operational performance metrics based on the tuned configuration of layer fusion and tensor tiling; performing an auto-tuning process to obtain a plurality of optimal configurations based on the first type of operational performance metrics and the second type of operational performance metrics; and configure the deep learning model according to one of the plurality of optimal configurations.

Abstract: An elastic shoe heel structure of a shoe includes a shoe heel and a shoe sole. The shoe heel is hollow or solid and has an upper edge soldered with a first end of a stepped elastic plate. The shoe heel has a stepped top surface corresponding in shape to the stepped elastic plate. An opposing second end of the stepped elastic plate has through holes for insertion of rivets to be connected to rivet holes of a rear section of the shoe sole. A gap is defined between the stepped elastic plate and the stepped top surface. When the user walks, a bottom of the shoe heel is contact with the ground and transfers a force from the shoe heel to the stepped elastic plate. The stepped elastic plate is compressed to absorb the force, providing a buffer effect.

Abstract: A method for quantifying a rapid immunochromatographic test includes the steps of: acquiring a digital image of a rapid immunochromatographic test with an image acquiring unit, acquiring at least one main characteristics of the digital image with a characteristics acquiring unit, calculating and quantifying the main characteristics of the digital image with a neural-network quantifying unit, and sending results of the quantification to an output unit.

Abstract: An integrated multi-purpose wireless network transceiver comprises a case holding a wireless network card or wireless network access device through wireless transmission to interface with the computer server at a client or access end, a flipping device on top, a holder for memo paper and a knob to support an upright pen holder. The flipping device comprises a preset board and a connected flipping cover. On top of the preset board, there is an electronic calculator module for numerical calculation. Below the electronic calculator module, an electronic clock and calendar, module are connected to set time, alarm and calendar. At the inner side of the flipping cover, there is a display available to show the formula and results for the electronic calculator, and the time and date for the electronic clock. This integrated design is provided to the multi-purpose wireless network transceiver for the present invention.