Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a core member and an engagement mechanism for releasably engaging a radially expandable valve anchor of the valve prosthesis along the core member. The engagement mechanism can include a pin assembly slidably coupled to the core member and a nose cone including a lock component slidably coupled along the core member to permit the valve anchor to disengage from the pin assembly.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a core member and an engagement mechanism for releasably engaging a radially expandable valve anchor of the valve prosthesis along the core member. The engagement mechanism can include a pin assembly slidably coupled to the core member and a nose cone including a lock component slidably coupled along the core member to permit the valve anchor to disengage from the pin assembly.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a core member and an engagement mechanism for releasably engaging a radially expandable valve anchor of the valve prosthesis along the core member. The engagement mechanism can include a pin assembly slidably coupled to the core member and a nose cone including a lock component slidably coupled along the core member to permit the valve anchor to disengage from the pin assembly.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: Methods of assembling and delivering a valve prosthesis and delivery system are disclosed herein. A method can include housing a valve prosthesis in a compacted state within a sheath of a delivery system. The valve prosthesis can include a valve anchor and a support frame coupled to the valve anchor, and the valve anchor can include a plurality of anchoring legs having a plurality of connection apertures. The method can further include slidably coupling a pin assembly around a core member so that the pin assembly is slidable longitudinally along the core member, and inserting a plurality of pins of the pin assembly through the plurality of connection apertures of the valve anchor and a plurality of lock apertures of the delivery system to engage the plurality of anchoring legs of the valve anchor.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: The present disclosure relates to heart valve prostheses, delivery devices, actuation handles, and other improved devices and methods that facilitate delivery of a heart valve prosthesis to a defective native valve structure in a patient, such as the aortic valve.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The valve prosthesis can include a valve anchor having a longitudinal axis and proximal and distal end portions. The valve anchor can include a plurality of U-shaped members and a plurality of anchoring legs, each of the plurality of anchoring legs comprising a connection aperture at a distal end portion thereof and a longitudinal slot extending along a length of the anchoring leg, wherein the plurality of anchoring legs and the plurality of U-shaped members can radially expand in stages to permit a native valve structure to be interposed therebetween for anchoring the valve prosthesis relative to the native valve structure.

Abstract: A valve prosthesis and a system for delivering a valve prosthesis are described herein. The system can include a support frame, a valve anchor comprising an anchoring leg and a plurality of U-shaped members, and a suture coupled to the support frame and slidably coupled to the anchoring leg.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.

Abstract: This invention relates to combinations of therapeutic molecules useful for treating hepatitis C virus infection. The present invention relates to methods, uses, dosing regimens, and compositions.