Abstract: The present disclosure relates to utilizing the N6-methyllysine for reducing fat percentage in an organ or tissue or for treating obesity, obesity-related diseases or cancers. More specifically, the present invention relates to the method using N?-Methyl-L-lysine or N?-Methyl-L-lysine producing bacteria or N?-Methyl-L-lysine/l-lysine mixture or N?-Methyl-L-lysine/probiotics mixture to treat obesity, obesity-related diseases or cancers.

Abstract: The present disclosure relates to utilizing the N6-methyllysine for reducing fat percentage in an organ or tissue or for treating obesity, obesity-related diseases or cancers. More specifically, the present invention relates to the method using N?-Methyl-L-lysine or N?-Methyl-L-lysine producing bacteria or N?-Methyl-L-lysine/l-lysine mixture or N?-Methyl-L-lysine/probiotics mixture to treat obesity, obesity-related diseases or cancers.

Abstract: One or more predetermined combination of human use (e.g., including animals) probiotics and specific ranges of ratio of anti-obesity human use probiotics compositions and their preparation methods and uses are provided. Particularly, the Present Disclosure provides a specific composition of food-grade probiotics been shaped by germ-free or antibiotics-treated dual-specificity phosphatase 6 (Dusp6) deficient mammal, which is effective in altering a relative abundance of gut microbiota and also useful in reducing body weight, fat mass, and/or size of adipocytes and increasing oxygen consumption and/or energy expenditure and thus can be used to treat or prevent obesity, manage blood glucose level, or their associated metabolic disorders or conditions in a subject in need.

Abstract: The present invention relates to microbiota compositions and their preparation methods and uses. Particularly, the present invention provides microbiota compositions collected from a dual-specificity phosphatase 6 (dusp6) deficient mammal, which is effective in altering a relative abundance of gut microbiota and also useful in reducing body weight, fat mass, and/or size of adipocytes and increasing oxygen consumption and/or energy expenditure and thus can be used to treat or prevent obesity or its associated disorders or conditions in a subject in need.

Abstract: The present invention relates to microbiota compositions and their preparation methods and uses. Particularly, the present invention provides microbiota compositions collected from a dual-specificity phosphatase 6 (dusp6) deficient mammal, which is effective in altering a relative abundance of gut microbiota and also useful in reducing body weight, fat mass, and/or size of adipocytes and increasing oxygen consumption and/or energy expenditure and thus can be used to treat or prevent obesity or its associated disorders or conditions in a subject in need.